DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bap55 and ACTL6B

DIOPT Version :9

Sequence 1:	NP_611209.1	Gene:	Bap55 / 36956	FlyBaseID:	FBgn0025716	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_057272.1	Gene:	ACTL6B / 51412	HGNCID:	160	Length:	426	Species:	Homo sapiens

Alignment Length:	440	Identity:	246/440 - (55%)
Similarity:	322/440 - (73%)	Gaps:	29/440 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGGTMLYGGDEIGALVFDPGHHSLRVGYAQEDSPKAEIPSVVGIGAAPE-TNLDPETKTDNNAT 64
            ||||  :|||||:||||||.|..|:|.|||.||.|||:.|:.||:.||.| ..|:.|
Human     1 MSGG--VYGGDEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELE-------- 55

  Fly    65 PNNADQRK----FYVDTNYVTVPRSNMEVQTYMKDGMIDNWDLFEKVIDYAYANVIQSEPEYHPV 125
               .|:.|    |::|||.:.|||...||.:.:|:|||::|:.|..::|:.|:..::|||..|||
Human    56 ---GDKEKKGKIFHIDTNALHVPRDGAEVMSPLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPV 117

  Fly   126 LFSEASWNVRNNREKLTELMFEKYNVPAFFLVKNAVLAAFSSGRATALVVDSGATHTSAVPVHEG 190
            |.|||.||.|..||||||||||:||:|||||.|.|||.||::||:|.||:|||||||:|:|||:|
Human   118 LMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDG 182

  Fly   191 YVLSQAVVKSPLGGDFLSRQCRQHLEKHGIDLSPVYKIASKDVVKERDNGRFTLR-KLPENLTQS 254
            |||.|.:|||||.|||:|.|||:..::..||:.|.|.||:|:.|:|.....:..: |||: :::|
Human   183 YVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQ-VSKS 246

  Fly   255 WQNYMLQLMMQDFQMNVLQVLENPFDERVAAQIPTVHYEFPNGYHQDFGSERFKIAESLFD---- 315
            |.|||...::||||.:||||.::|:||:||||:||||||.||||:.|:|:||.:|.|.|||
Human   247 WHNYMCNEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNV 311

  Fly   316 -----NAMLGAGQLASTSVGMCDADVRLSLFGSVVVTGGNTLLQGFPERLNRDLQLRAPSNTRLK 375
                 |.|||.|.:.:||:||||.|:|..|:|||:|||||||||||.:||||:|..:.|.:.|||
Human   312 KGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLK 376

  Fly   376 MISANGSVERRFGAWIGGSILASIGTFQQMWISSQEYEEAGKSQVERKCP 425
            :|::|.::||:|..|||||||||:|||||||||.|||||.||..||||||
Human   377 LIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKCP 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bap55	NP_611209.1	Actin	13..425	CDD:394979	235/426 (55%)
ACTL6B	NP_057272.1	Actin	11..426	CDD:394979	235/426 (55%)
ACTL6B	NP_057272.1	Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000250\|UniProtKB:Q99MR0	39..82		17/53 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	482	1.000	Domainoid score	I412
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1416
Isobase	1	0.950	-	0	Normalized mean entropy	S833
OMA	1	1.010	-	-		QHG55702
OrthoDB	1	1.010	-	-		D300517at33208
OrthoFinder	1	1.000	-	-		FOG0001878
OrthoInspector	1	1.000	-	-		otm41310
orthoMCL	1	0.900	-	-		OOG6_102754
Panther	1	1.100	-	-	LDO	PTHR11937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4301
SonicParanoid	1	1.000	-	-		X1579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820