DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bap55 and POTEE

DIOPT Version :9

Sequence 1:	NP_611209.1	Gene:	Bap55 / 36956	FlyBaseID:	FBgn0025716	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001077007.1	Gene:	POTEE / 445582	HGNCID:	33895	Length:	1075	Species:	Homo sapiens

Alignment Length:	422	Identity:	133/422 - (31%)
Similarity:	213/422 - (50%)	Gaps:	58/422 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DEIGALVFDPGHHSLRVGYAQEDSPKAEIPSVVGIGAAPETNLDPETKTDNNATPNNADQRKFYV 75
            |:...||.|.|....:.|:|.:|:|:|..||:||             :...........|::.||
Human   703 DDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVG-------------RPRQQGMMGGMHQKESYV 754

  Fly    76 DTNYVTVPRSNMEVQTYMKDGMIDNWDLFEKVIDYAYANVIQSEPEYHPVLFSEASWNVRNNREK 140
            ... ....|..:.::..|:.|:|.|||..||:..:.:.|.::..||.||:|.:||..|.:.||||
Human   755 GKE-AQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREK 818

  Fly   141 LTELMFEKYNVPAFFLVKNAVLAAFSSGRATALVVDSGATHTSAVPVHEGYVLSQAVVKSPLGGD 205
            :|::|||.:|.||.::...||.:.::|||.|.:|:|||...|..||::||..|..|.::..|.|
Human   819 MTQIMFETFNTPAMYVAIQAVPSLYTSGRTTGIVMDSGDGVTHTVPIYEGNALPHATLRLDLAG- 882

  Fly   206 FLSRQCRQHLEKHGIDLSPVYKIASKDVVKERDNGRFTL---RKLPENLTQSWQNYMLQLMMQDF 267
               |:...:|.|               ::.|| ..|||.   |::..::.:.     |..:..||
Human   883 ---RELPDYLMK---------------ILTER-GYRFTTMAEREIVRDIKEK-----LCYVALDF 923

  Fly   268 QMNVLQVLENPFDERVAAQIPTVHYEFPNGYHQDFGSERFKIAESLFDNAML-----GAGQLAST 327
            :..:.....:...|:        .||.|:|.....|:|||:..|:||....|     |..:....
Human   924 EQEMATAASSSSLEK--------SYELPDGQVITIGNERFRCPEALFQPCFLGMESCGIHETTFN 980

  Fly   328 SVGMCDADVRLSLFGSVVVTGGNTLLQGFPERLNRDLQLRAPSNTRLKMISANGSVERRFGAWIG 392
            |:...|.|:|..|:.:.|::||.|:..|...|:.:::...|||..::::|:   ..:|::..|:|
Human   981 SIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMMKIRIIA---PPKRKYSVWVG 1042

  Fly   393 GSILASIGTFQQMWISSQEYEEAGKSQVERKC 424
            ||||||:.||||||||.|||:|:|.|.|.|||
Human  1043 GSILASLSTFQQMWISKQEYDESGPSIVHRKC 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bap55	NP_611209.1	Actin	13..425	CDD:394979	132/420 (31%)
POTEE	NP_001077007.1	Ank_4	143..193	CDD:290365
		ANK	167..292	CDD:238125
		ANK 1	172..201
		ANK repeat	174..203	CDD:293786
		Ank_2	177..269	CDD:289560
		ANK repeat	205..236	CDD:293786
		ANK 2	205..234
		ANK	233..357	CDD:238125
		ANK repeat	238..269	CDD:293786
		ANK 3	238..267
		Ank_2	243..335	CDD:289560
		ANK repeat	271..302	CDD:293786
		ANK 4	271..300
		ANK repeat	304..335	CDD:293786
		ANK 5	304..333
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..530
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..599
		NBD_sugar-kinase_HSP70_actin	701..1075	CDD:302596	133/422 (32%)
		Actin-like	702..1075		133/422 (32%)
		ACTIN	705..1075	CDD:214592	132/420 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820