DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bap55 and ACTL7A

DIOPT Version :9

Sequence 1:	NP_611209.1	Gene:	Bap55 / 36956	FlyBaseID:	FBgn0025716	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_006678.1	Gene:	ACTL7A / 10881	HGNCID:	161	Length:	435	Species:	Homo sapiens

Alignment Length:	421	Identity:	115/421 - (27%)
Similarity:	189/421 - (44%)	Gaps:	68/421 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ALVFDPGHHSLRVGYAQEDSPKAEIPSVVGIGAAP--ETNLDPETKTDNNATPNNADQRKFYVDT 77
            |:|.|.|....:.|:|....|..:|.:.||   .|  ||     .||.:|.......|     :.
Human    71 AVVVDLGTGYCKCGFAGLPRPTHKISTTVG---KPYMET-----AKTGDNRKETFVGQ-----EL 122

  Fly    78 NYVTVPRSNMEVQTYMKDGMIDNWDLFEKVIDYAYANVIQSEPEYHPVLFSEASWNVRNNREKLT 142
            |...|   ::::...::.|:|.:||..:.:.:|.:...::..||.|.||.|:...:...||||..
Human   123 NNTNV---HLKLVNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYA 184

  Fly   143 ELMFEKYNVPAFFLVKNAVLAAFSSGRATALVVDSGATHTSAVPVHEGYVLSQAVVKSPLGGDFL 207
            |::||.:|.||..:...:.|:.:|.||.:.|||:.|...:..||::|||.|.....:
Human   185 EMLFEAFNTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGR-------- 241

  Fly   208 SRQCRQHLEKHGIDLSPVYKIASKDVVKERDNGRFTLRKLPENLTQSWQNYMLQLMMQDFQMNVL 272
                   |:..|.||: .|.:.             .|.......||....     :::|.:....
Human   242 -------LDYAGSDLT-AYLLG-------------LLNSAGNEFTQDQMG-----IVEDIKKKCC 280

  Fly   273 QVLENPFDERVAAQIP----TVHYEFPNGYHQDFGSERFKIAESLFDNAMLGAGQL-----ASTS 328
            .|..:|.:|:   ::|    |:.|..|:|.......|||..:|..|..:::.:.||     ..:.
Human   281 FVALDPIEEK---KVPLSEHTIRYVLPDGKEIQLCQERFLCSEMFFKPSLIKSMQLGLHTQTVSC 342

  Fly   329 VGMCDADVRLSLFGSVVVTGGNTLLQGFPERLNRDLQLRAPSNTRLKMISANGSVERRFGAWIGG 393
            :..||..::..|.|::::.||:|:|.|||.||.::|....|::|.    ..|...||....|.||
Human   343 LNKCDIALKRDLMGNILLCGGSTMLSGFPNRLQKELSSMCPNDTP----QVNVLPERDSAVWTGG 403

  Fly   394 SILASIGTFQQMWISSQEYEEAGKSQVERKC 424
            |||||:..||.:|:...||||.|...:.|:|
Human   404 SILASLQGFQPLWVHRFEYEEHGPFFLYRRC 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bap55	NP_611209.1	Actin	13..425	CDD:394979	115/421 (27%)
ACTL7A	NP_006678.1	ACTL7A_N	1..65	CDD:293445
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		Required for interaction with TES	31..51
		NBD_sugar-kinase_HSP70_actin	67..435	CDD:302596	115/421 (27%)
		ACTIN	69..435	CDD:214592	115/421 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900