DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bap55 and ACTL7B

DIOPT Version :9

Sequence 1:	NP_611209.1	Gene:	Bap55 / 36956	FlyBaseID:	FBgn0025716	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_006677.1	Gene:	ACTL7B / 10880	HGNCID:	162	Length:	415	Species:	Homo sapiens

Alignment Length:	435	Identity:	119/435 - (27%)
Similarity:	197/435 - (45%)	Gaps:	89/435 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EIGALVFDPGHHSLRVGYAQEDSPKAEIPSVVGIGAAPETNLDPETKTDNNATPNNADQRKFYVD 76
            :|.|::.|.|....:.|||.|..|...|.|.|| ...||             ..:..|.||:.:.
Human    48 KIKAVIIDLGSQYCKCGYAGEPRPTYFISSTVG-KRCPE-------------AADAGDTRKWTLV 98

  Fly    77 TNYVTVPRSNMEVQTYMKDGMIDNWDLFEKVIDYAYANVIQSEPEYHPVLFSEASWNVRNNREKL 141
            .:.:....:.:::...:|.|::.:||..:.:.:|.:...::..||.|.||.|:...:..:||||.
Human    99 GHELLNTEAPLKLVNPLKHGIVVDWDCVQDIWEYIFRTAMKILPEEHAVLVSDPPLSPSSNREKY 163

  Fly   142 TELMFEKYNVPAFFLVKNAVLAAFSSGRATALVVDSGATHTSAVPVHEGYVLSQAVVKSP-LGGD 205
            .|||||.:.:||..:...::|:.:|.|:.:.|||:||...:..||:.||.||.....::. .|||
Human   164 AELMFETFGIPAMHVTSQSLLSIYSYGKTSGLVVESGHGVSHVVPISEGDVLPGLTSRADYAGGD 228

  Fly   206 FLSRQCRQHLEKHGIDLSPVYKIASKDVVKERDNGRFTLRKLPENLTQSWQNYMLQLMMQ----- 265
                                                         ||    ||::||:.:
Human   229 ---------------------------------------------LT----NYLMQLLNEAGHAF 244

  Fly   266 -DFQMNVLQVLENP------FDERVAAQIP---TVHYEFPNGYHQDFGSERFKIAESLFDNAMLG 320
             |..:::::.::..      ..|.....:|   .|.||.|:|.....|.|||:.:|.||..::.|
Human   245 TDDHLHIIEHIKKKCCYAAFLPEEELGLVPEELRVDYELPDGKLITIGQERFRCSEMLFQPSLAG 309

  Fly   321 AGQ-----LASTSVGMC-DADVRLSLFGSVVVTGGNTLLQGFPERLNRDLQLRAPSNTRLKMISA 379
            :.|     |.:..:|.| |...:..:..:|::.||.|:|.|||||..|:|.|..|.::.    :.
Human   310 STQPGLPELTAACLGRCQDTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDSP----AV 370

  Fly   380 NGSVERRFGAWIGGSILASIGTFQQMWISSQEYEEAGKSQVERKC 424
            ..:.||:...|.|||||||:..|||:|:|.:|:||.|...:..||
Human   371 AAAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGSVAIYSKC 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bap55	NP_611209.1	Actin	13..425	CDD:394979	119/434 (27%)
ACTL7B	NP_006677.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
ACTL7B	NP_006677.1	NBD_sugar-kinase_HSP70_actin	51..415	CDD:327376	116/430 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810