DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6550 and cdkal1

DIOPT Version :9

Sequence 1:	NP_611207.1	Gene:	CG6550 / 36954	FlyBaseID:	FBgn0034214	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_012819891.1	Gene:	cdkal1 / 394802	XenbaseID:	XB-GENE-5895778	Length:	579	Species:	Xenopus tropicalis

Alignment Length:	561	Identity:	335/561 - (59%)
Similarity:	424/561 - (75%)	Gaps:	29/561 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LGQDLPG---NDVDDIEDLISADDVKPRERYENKKTVTVRAKKRSQIRLESQEEEEKPKPTIHES 65
            :||::|.   :.:|||||::||.|.||.:|...::.:..||:||::.::   :|||.|.    :|
Frog    23 VGQEMPAACESLLDDIEDIVSATDPKPHDRQNARQNIVPRARKRNKNKI---QEEEPPA----DS 80

  Fly    66 VIPGTQKVFVKTWGCAHNNSDSEYMAGQLAAYGYRLSGK-EEADLWLLNSCTVKNPSEDTFRNEI 129
            .||||||::::||||:|||||.||||||||||||.::.: |:||||||||||||:|:||.|||.|
Frog    81 TIPGTQKIWIRTWGCSHNNSDGEYMAGQLAAYGYSITEQPEQADLWLLNSCTVKSPAEDHFRNSI 145

  Fly   130 ESGMRNGKHVVVAGCVPQGAPKSDYLNGLSVIGVQQIDRVVEVVEETLKGHSVQLLQNKKKVHGR 194
            :......|.||::|||||..|:.:|:.|||:||||||||||||||||:|||||:|| .:||.:|:
Frog   146 KKAQEANKKVVLSGCVPQAQPRQEYMKGLSIIGVQQIDRVVEVVEETIKGHSVRLL-GQKKDNGK 209

  Fly   195 RVAGAPLSLPKVRKNPLIEIISINSGCLNQCTYCKTKHARGDLASYPPEEVVERARQSFAEGCCE 259
            |:.||.|.|||:||||||||||||:||||.|||||||||||:|||||.||:|:||.|||.||.||
Frog   210 RLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGELASYPVEELVDRAAQSFQEGVCE 274

  Fly   260 IWLTSEDTGAYGRDIGSSLPELLWQLVEVIPEHCMLRVGMTNPPYILEHLEEVANVLQHPRVYSF 324
            ||||||||||||||||:.||.|||:|||||||..|||:||||||||||||||:|.:|.|||||:|
Frog   275 IWLTSEDTGAYGRDIGTDLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAF 339

  Fly   325 LHVPVQSGSDSVLGEMKREYCRQDFEHVVDFLRERVPGVTIATDIICGFPTETEDDFEETMTLCA 389
            ||:||||.|||||.:||||||..||:.|||||:|||||:|||||||||||.||::||:||:.|..
Frog   340 LHIPVQSASDSVLMDMKREYCIADFKRVVDFLKERVPGITIATDIICGFPGETDEDFKETLKLVE 404

  Fly   390 KYRFPSLFINQFFPRPGTPAAKMDRIPANLVKKRTKRLTDLFYSYEPYADRVGEIYTVLVTEVSH 454
            :|:|||||||||:||||||||||:::||::.|:|||.|:.||:||.||..::||...|||||.|.
Frog   405 EYKFPSLFINQFYPRPGTPAAKMEQVPAHVKKQRTKELSQLFHSYSPYDHKIGEEQHVLVTEESF 469

  Fly   455 DKLHYVGHNKSYEQVLLPMRDNLLGTRVHVRITSASKFSMVGEILDDERDWTRC----------- 508
            |..:||.||:.|||||:|.....:|..|.|:|..|.|..|.|:.:.|...:|..
Frog   470 DSQYYVSHNRFYEQVLVPKDPAFVGKMVEVKIFEAGKHFMKGQPVQDSYIYTPSITKPLAKGEVS 534

  Fly   509 -----AKNQELPNVQVQTRSRERLIQRYFGIALVLGSLAFL 544
                 :|....|...:|| |||.|...:|..||:...:||:
Frog   535 GLTEESKPPNNPESLLQT-SREGLQTFFFVTALLAAVIAFV 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6550	NP_611207.1	MiaB-like-B	72..549	CDD:273703	307/490 (63%)
		UPF0004	72..151	CDD:279287	50/79 (63%)
		Radical_SAM	215..413	CDD:100105	155/197 (79%)
cdkal1	XP_012819891.1	MiaB-like-B	87..514	CDD:273703	292/427 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I1498
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9830
Inparanoid	1	1.050	661	1.000	Inparanoid score	I760
OMA	1	1.010	-	-		QHG62224
OrthoDB	1	1.010	-	-		D407532at33208
OrthoFinder	1	1.000	-	-		FOG0005706
OrthoInspector	1	1.000	-	-		otm48668
Panther	1	1.100	-	-	LDO	PTHR11918
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4103
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080