DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)k01209 and ATCAY

DIOPT Version :9

Sequence 1:	NP_725672.2	Gene:	l(2)k01209 / 36953	FlyBaseID:	FBgn0022029	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_149053.1	Gene:	ATCAY / 85300	HGNCID:	779	Length:	371	Species:	Homo sapiens

Alignment Length:	357	Identity:	75/357 - (21%)
Similarity:	126/357 - (35%)	Gaps:	118/357 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 GQQVE-----PFVIGICGGSASGKTTVAEKIIESLDVPWVTLLSMDCFYKILNEKQHEQALINEY 240
            |..||     |..:...|.....||.||.:|..|||                   |.|.:|:::.
Human    38 GSPVEDTSSPPNTLNFNGAHRKRKTLVAPEINISLD-------------------QSEGSLLSDD 83

  Fly   241 NFDHPDAFDIELLLDVLTKLKEGRKVEVPVYNFVTHGRE---------SQTKTMYGANVIIF-EG 295
            ..|.||  |:::.:|.:....|...:|     |:.:|.|         :..|.|.|.:..:| :|
Human    84 FLDTPD--DLDINVDDIETPDETDSLE-----FLGNGNELEWEDDTPVATAKNMPGDSADLFGDG 141

  Fly   296 ILTFHSPEVLKLLDMKIFVDTDPDIRLAR-RLRRDI---SQRGRDLKGVLKQYLNMVKPS--YCN 354
                                |..|...|. ||.|.:   .|..|....:::.|:.:|...  |..
Human   142 --------------------TTEDGSAANGRLWRTVIIGEQEHRIDLHMIRPYMKVVTHGGYYGE 186

  Fly   355 YIAPTMAHADIIVPRGGDNKVA-IHLIVQ----HVHTQLQLRGFKLRETLANSYKDQPMPHSLHL 414
            .:...:..|...:|   |:.:. .|.|::    :|.:.|:|       .:|..|.      .::|
Human   187 GLNAIIVFAACFLP---DSSLPDYHYIMENLFLYVISSLEL-------LVAEDYM------IVYL 235

  Fly   415 LHPTPQ--------IKGLHTFI--RCRNTSRDEFIFYSKRLIRLV---------------IEYAL 454
            ...||:        :|..:..|  |.|...:...|.:....||.|               |:|..
Human   236 NGATPRRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFISVKFINKIQYVH 300

  Fly   455 SLFPFKKTT----VETPQGVL-YEGKRMESRK 481
            ||...::..    |:.|..|| ||.:|:::|:
Human   301 SLEDLEQLIPMEHVQIPDCVLQYEEERLKARR 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k01209	NP_725672.2	Udk	186..397	CDD:223645	47/231 (20%)
		UMPK	188..387	CDD:238981	44/219 (20%)
		UPRTase	417..620	CDD:291353	22/95 (23%)
ATCAY	NP_149053.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		4/15 (27%)
		BNIP2	59..187	CDD:315215	37/173 (21%)
		Required for interaction with KLC1. /evidence=ECO:0000250	115..120		1/4 (25%)
		CRAL_TRIO_2	189..314	CDD:316255	25/140 (18%)
		Mediates interaction with GLS. /evidence=ECO:0000269\|PubMed:16899818	190..371		33/159 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..371		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0572
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900