DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)k01209 and uckl1b

DIOPT Version :9

Sequence 1:	NP_725672.2	Gene:	l(2)k01209 / 36953	FlyBaseID:	FBgn0022029	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	XP_005162063.1	Gene:	uckl1b / 558466	ZFINID:	ZDB-GENE-090311-45	Length:	537	Species:	Danio rerio

Alignment Length:	517	Identity:	327/517 - (63%)
Similarity:	401/517 - (77%)	Gaps:	29/517 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 TTVPAKASLD----------SPLKRSGRRQRTTSIGNQTTTANPSECIIRANNRTIYTAGRPPWY 177
            |:..|:.|||          ||      |:||||   |..:..|   ::|.:.||||||||||||
Zfish    24 TSGGAEDSLDRLLPTVNTSLSP------RKRTTS---QCKSEPP---LLRTSKRTIYTAGRPPWY 76

  Fly   178 NCAG-QQVEPFVIGICGGSASGKTTVAEKIIESLDVPWVTLLSMDCFYKILNEKQHEQALINEYN 241
            |..| |..|.||||:||||||||||||.||||:||||||.|||||.|||:|..:|..||..|:||
Zfish    77 NEHGTQSKEAFVIGLCGGSASGKTTVARKIIEALDVPWVVLLSMDSFYKVLTSEQQLQAASNDYN 141

  Fly   242 FDHPDAFDIELLLDVLTKLKEGRKVEVPVYNFVTHGRESQTKTMYGANVIIFEGILTFHSPEVLK 306
            ||||||||..||:..|.|||:|:.|::|||:|.||||:.:.||:|||:|||||||::|...|:||
Zfish   142 FDHPDAFDFVLLVHTLRKLKQGKSVKIPVYDFTTHGRQKEWKTVYGASVIIFEGIMSFADKELLK 206

  Fly   307 LLDMKIFVDTDPDIRLARRLRRDISQRGRDLKGVLKQYLNMVKPSYCNYIAPTMAHADIIVPRGG 371
            |||||||||||.||||.|||||||::||||::||:|||...|||::..||.|||..|||:|||||
Zfish   207 LLDMKIFVDTDSDIRLVRRLRRDITERGRDIEGVIKQYNKFVKPAFEQYIEPTMRLADIVVPRGG 271

  Fly   372 DNKVAIHLIVQHVHTQLQLRGFKLR---ETLANSYKDQPMPHSLHLLHPTPQIKGLHTFIRCRNT 433
            .|.|||.|||||||:||:.|  |||   ..||::::.||:|.:|.:|..|||::|:||.||.::|
Zfish   272 GNMVAIDLIVQHVHSQLEER--KLRWDMAALASAHQAQPLPQTLSVLESTPQVRGMHTIIRNKDT 334

  Fly   434 SRDEFIFYSKRLIRLVIEYALSLFPFKKTTVETPQGVLYEGKRMESRKICGVSILRAGETMEQAV 498
            :|||||||||||:||:||.|||..|.:...|:||||..|||:....::|.||||||||||||.|:
Zfish   335 NRDEFIFYSKRLMRLLIERALSFLPSQVHIVQTPQGEDYEGRIFHGKRITGVSILRAGETMEPAL 399

  Fly   499 CDVCKDIRIGKILIQTNLKTGEPELYYLRLPKDIKDYKVILMDATVATGAAAMMAIRVLLDHDVP 563
            ..||||:||||||||||..||||||:||||||||.:..|||||.||:|||||||||||||||||.
Zfish   400 RAVCKDVRIGKILIQTNQDTGEPELHYLRLPKDISEDHVILMDCTVSTGAAAMMAIRVLLDHDVQ 464

  Fly   564 EDNIILASLLMAEIGVHSIAYAFPKVKIVTSALDPEINSKFYVIPGIGNFGDRYFGTE-PSD 624
            |:.|:|.||||||:||||:|||||:|||:|:|:|.::|..|::||||||||||||||: |:|
Zfish   465 EEKILLVSLLMAEMGVHSVAYAFPQVKIITTAVDKKVNDLFHIIPGIGNFGDRYFGTDAPTD 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k01209	NP_725672.2	Udk	186..397	CDD:223645	145/213 (68%)
		UMPK	188..387	CDD:238981	138/198 (70%)
		UPRTase	417..620	CDD:291353	140/202 (69%)
uckl1b	XP_005162063.1	Udk	81..294	CDD:223645	145/214 (68%)
		UMPK	88..287	CDD:238981	138/198 (70%)
		UPRTase	318..521	CDD:291353	140/202 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579257
Domainoid	1	1.000	309	1.000	Domainoid score	I1304
eggNOG	1	0.900	-	-		E1_COG0572
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	656	1.000	Inparanoid score	I756
OMA	1	1.010	-	-		QHG55607
OrthoDB	1	1.010	-	-		D509086at33208
OrthoFinder	1	1.000	-	-		FOG0001406
OrthoInspector	1	1.000	-	-		otm25256
orthoMCL	1	0.900	-	-		OOG6_100147
Panther	1	1.100	-	-	LDO	PTHR10285
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1606
SonicParanoid	1	1.000	-	-		X779
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800