Protein Alignment l(2)k01209 and UCKL1

DIOPT Version :9

• Sequence 1: NP_725672.2
• Gene: l(2)k01209 / 36953
• FlyBaseID: FBgn0022029
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: XP_024307683.1
• Gene: UCKL1 / 54963
• HGNCID: 15938
• Length: 612
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 297/617 - (48%)
• Similarity: 362/617 - (58%)
• Gaps: 125/617 - (20%)

  Fly   114 DLNCCPASPTT---VPAK---------------ASLDS--PLKRSGR--RQRTTSIGNQTTTANP 156
            |.:..|.||.|   .|.:               .|||.  |...:||  |:||||   |..:..|
Human     9 DADPSPTSPPTARDTPGRQAEKSETACEDRSNAESLDRLLPPVGTGRSPRKRTTS---QCKSEPP 70

  Fly   157 SECIIRANNRTIYTAGRPPWYNCAG-QQVEPFVIGICGGSASGKTTVAEKIIESLDVPWVTLLSM 220
               ::|.:.|||||||||||||..| |..|.|.||:.|||||||||||..|||:||||||.||||
Human    71 ---LLRTSKRTIYTAGRPPWYNEHGTQSKEAFAIGLGGGSASGKTTVARMIIEALDVPWVVLLSM 132

  Fly   221 DCFYK--------ILNEKQHEQALINEYNFDHPDAFDIELLLDVLTKLKEGRKVEVPVYNFVTHG 277
            |.|||        :|.|:|.|||..|.:|||||||||.:|::..|.|||:|:.|:||:|:|.||.
Human   133 DSFYKLLHSLPHQVLTEQQQEQAAHNNFNFDHPDAFDFDLIISTLKKLKQGKSVKVPIYDFTTHS 197

  Fly   278 RESQTKTMYGANVIIFEGILTFHSPEVLKLLDMKIFVDTDPDIRLARRLRRDISQRGRDLKGVLK 342
            |:...||:|||||||||||:.|....:|:|||||||||||.||||.||||||||:||||::||:|
Human   198 RKKDWKTLYGANVIIFEGIMAFADKTLLELLDMKIFVDTDSDIRLVRRLRRDISERGRDIEGVIK 262

  Fly   343 QYLNMVKPSYCNYIAPTMAHADIIVPRGGDNKVAIHLIVQHVHTQLQLRGFKLRETLANSYKDQP 407
            ||...||||:..||.|||..|||:||||..|.|||.|||||||:||:.....|...:..:..|..
Human   263 QYNKFVKPSFDQYIQPTMRLADIVVPRGSGNTVAIDLIVQHVHSQLEEGCAGLGTPVPPAAPDAE 327

  Fly   408 MP--------HSLHLLHPTPQIKGLHTFIRCRNTSRDEFIFYSKRLIRLVIEYALSLFPFKKTTV 464
            .|        |:.|......|.:.:|..::    ..|.....::.|:.       :|...::|
Human   328 RPEEHAAGTGHAHHHQGQGDQSRRVHLLLQ----ETDAAAHRARALLP-------ALSGLRRT-- 379

  Fly   465 ETPQGVLYEGK--------------------------RMESRKICGVSILRAGETMEQAVCDVCK 503
             .|.|....|:                          .:.|.:|.||||||||||||.|:..|||
Human   380 -DPAGAGLCGQVLCGEAGTCLGTPGRGTGCWGGMWALSLPSPQITGVSILRAGETMEPALRAVCK 443

  Fly   504 DIRIGKILIQTNLKTGEPE------------------------------------LYYLRLPKDI 532
            |:|||.||||||..|||||                                    |:||||||||
Human   444 DVRIGTILIQTNQLTGEPEVPGGSRGDEPGGRGQRELTARGRREPHLQPDPCCPQLHYLRLPKDI 508

  Fly   533 KDYKVILMDATVATGAAAMMAIRVLLDHDVPEDNIILASLLMAEIGVHSIAYAFPKVKIVTSALD 597
            .|..|||||.||:||||||||:|||||||||||.|.|.||||||:||||:|||||:|:|:|:|:|
Human   509 SDDHVILMDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVHSVAYAFPRVRIITTAVD 573

  Fly   598 PEINSKFYVIPGIGNFGDRYFGTEP----SDE 625
            ..:|..|.:||||||||||||||:.    |||
Human   574 KRVNDLFRIIPGIGNFGDRYFGTDAVPDGSDE 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k01209	NP_725672.2	Udk	186..397	CDD:223645	138/218 (63%)
		UMPK	188..387	CDD:238981	134/206 (65%)
		UPRTase	417..620	CDD:291353	114/264 (43%)
UCKL1	XP_024307683.1	UMPK	101..307	CDD:238981	134/205 (65%)
		UPRTase	<417..596	CDD:317125	105/178 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145814
Domainoid	1	1.000	292	1.000	Domainoid score	I1531
eggNOG	1	0.900	-	-		E1_COG0572
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	620	1.000	Inparanoid score	I884
Isobase	1	0.950	-	0	Normalized mean entropy	S975
OMA	1	1.010	-	-		QHG55607
OrthoDB	1	1.010	-	-		D509086at33208
OrthoFinder	1	1.000	-	-		FOG0001406
OrthoInspector	1	1.000	-	-		oto89877
orthoMCL	1	0.900	-	-		OOG6_100147
Panther	1	1.100	-	-	LDO	PTHR10285
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1606
SonicParanoid	1	1.000	-	-		X779
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750