DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)k01209 and SPCC162.11c

DIOPT Version :9

Sequence 1:	NP_725672.2	Gene:	l(2)k01209 / 36953	FlyBaseID:	FBgn0022029	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_001342737.1	Gene:	SPCC162.11c / 2538946	PomBaseID:	SPCC162.11c	Length:	454	Species:	Schizosaccharomyces pombe

Alignment Length:	444	Identity:	176/444 - (39%)
Similarity:	279/444 - (62%)	Gaps:	15/444 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 ECIIRANNRTIYTAGRPPWYNCAGQQVEPFVIGICGGSASGKTTVAEKIIESLDVPWVTLLSMDC 222
            |...|.::...|   .|||     ::|.  .|||.|.|.||||:||:.|:::|::|.|.:||:|.
pombe     3 EAFERYSSNPTY---EPPW-----RKVR--FIGIAGPSGSGKTSVAQLIVKALNLPHVVILSLDS 57

  Fly   223 FYKILNEKQHEQALINEYNFDHPDAFDIELLLDVLTKLKEGRKVEVPVYNFVTHGRESQTKTMYG 287
            |||.||.:|.::|..|:|:||.|:|.|.:||...|.:||:||||::|:|:|..|.|..:|.|::|
pombe    58 FYKSLNAEQKKRAFNNDYDFDSPEAIDWDLLFVKLLELKQGRKVDIPIYSFNEHNRLPETNTLFG 122

  Fly   288 ANVIIFEGILTFHSPEVLKLLDMKIFVDTDPDIRLARRLRRDISQRGRDLKGVLKQYLNMVKPSY 352
            |::||.|||...:..::..|||:.:|:|||.|:.|:|||.|||:.||||:.|||:||...|||||
pombe   123 ASIIILEGIFALYDEKIRSLLDVSVFLDTDSDVCLSRRLNRDINYRGRDIVGVLEQYNKFVKPSY 187

  Fly   353 CNYIAPTMAHADIIVPRGGDNKVAIHLIVQHVHTQLQLRG---FKLRETLANSYKDQP-MPHSLH 413
            .|::...:::.|:|||||.|||:||.:::..:...|.::.   .|..::|.......| :|.:|.
pombe   188 ENFVRRQLSYTDLIVPRGRDNKLAIDMVINFIRRTLSIQSETHVKNIDSLQQIVPTIPHLPLNLV 252

  Fly   414 LLHPTPQIKGLHTFIRCRNTSRDEFIFYSKRLIRLVIEYALSLFPFKKTTVETPQGVLYEGKRME 478
            .|..||:|..:.|.:..:||..|:..|:..|:..:::..|.....::|.|:....|..:||.:|
pombe   253 QLKITPEISAIRTILINKNTHPDDLQFFLSRIGTMLMNLAGDSLAYEKKTITLHNGNQWEGLQM- 316

  Fly   479 SRKICGVSILRAGETMEQAVCDVCKDIRIGKILIQTNLKTGEPELYYLRLPKDIKDYKVILMDAT 543
            ::::||||:||:|.|:|.|:|.....:.:||||:|.|..|.||.|:|.:||:.|....|:||.:.
pombe   317 AKELCGVSVLRSGGTLETALCRQFPTVCLGKILVQINKVTQEPTLHYHKLPRGIATMNVVLMASH 381

  Fly   544 VATGAAAMMAIRVLLDHDVPEDNIILASLLMAEIGVHSIAYAFPKVKIVTSALD 597
            :.|.|..:||.::|:|..|||:|||:...:.....:.::||.||||.|||:.|:
pombe   382 LTTHADVLMATQILVDFGVPEENIIIVVYVCYSESIKALAYIFPKVTIVTAFLE 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k01209	NP_725672.2	Udk	186..397	CDD:223645	98/213 (46%)
		UMPK	188..387	CDD:238981	96/198 (48%)
		UPRTase	417..620	CDD:291353	66/181 (36%)
SPCC162.11c	NP_001342737.1	UMPK	23..220	CDD:238981	96/196 (49%)
SPCC162.11c	NP_001342737.1	Upp	250..454	CDD:223113	68/187 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	202	1.000	Domainoid score	I646
eggNOG	1	0.900	-	-		E1_COG0572
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41203
Inparanoid	1	1.050	326	1.000	Inparanoid score	I534
OMA	1	1.010	-	-		QHG55607
OrthoFinder	1	1.000	-	-		FOG0001406
OrthoInspector	1	1.000	-	-		oto101202
orthoMCL	1	0.900	-	-		OOG6_100147
Panther	1	1.100	-	-	LDO	PTHR10285
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1606
SonicParanoid	1	1.000	-	-		X779
TreeFam	1	0.960	-	-
	14	13.860