Protein Alignment l(2)k01209 and Jup

DIOPT Version :10

• Sequence 1: NP_725672.2
• Gene: l(2)k01209 / 36953
• FlyBaseID: FBgn0022029
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_034723.1
• Gene: Jup / 16480
• MGIID: 96650
• Length: 745
• Species: Mus musculus
• Alignment Length: 592
• Identity: 117/592 - (19%)
• Similarity: 190/592 - (32%)
• Gaps: 216/592 - (36%)

  Fly    95 VTE--QLYVDPYADLSNGLPGDLNCCPASPTTVPAKASLDSPLKRSGRRQRTTSIGNQTTTANPS 157
            |||  |.|.     ..:|:...:|.|      ||:.:|       .|......:.|.|.|
Mouse    13 VTEWQQTYT-----YDSGIHSGVNTC------VPSVSS-------KGIMDEDDACGRQYT----- 54

  Fly   158 ECIIRANNRTIYTAGRPPWYNCAGQQV----------EPFVIGICGGSAS--------GKTTVAE 204
                 ....|.||.|.|........|:          |....|:.|..:|        |:||..:
Mouse    55 -----LKKTTTYTQGVPQNQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQTTNLQ 114

  Fly   205 KIIESLDVPWVTLLSMDCFYKILNEKQHEQALINEYNFDHPDAFDIELLLDVLTKLKEGRKVEVP 269
            ::.|    |...|.|               |:::..|:..    |.||....|.:|.:....|.|
Mouse   115 RLAE----PSQLLKS---------------AIVHLINYQD----DAELATRALPELTKLLNDEDP 156

  Fly   270 VYNFVTHG---------RESQTKTMYGANVIIFEGILTFHSPEVLKLLDMKIFVDTDPDIRLARR 325
            |  .||..         :|:..:.:.|:..::...:.|..:...|         ||   .|....
Mouse   157 V--VVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDL---------DT---ARCTTS 207

  Fly   326 LRRDISQRGRDLKGVLK--------QYLNMVKPSYCNYIAPTMAHADIIVPRGGDNKVAIHL--- 379
            :..::|.....|..:.|        :.|:....|...| |.|..|..::...|.  |:|:.|
Mouse   208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFY-AITTLHNLLLYQEGA--KMAVRLADG 269

  Fly   380 ---IVQHVHTQ-----------LQLRGFKLRET----LANSYKDQPMPHSLHLLHPTPQIKGLHT 426
               :|..::..           |||..:..:|:    |||.               .||  ||..
Mouse   270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANG---------------GPQ--GLVQ 317

  Fly   427 FIRCRNTSRDEFIFYSKRLIRLVIEYALSLFPFKKTTVETPQGVLYEGKRMES------------ 479
            .:  ||.|.::.::.:.|::::     ||:.|..|..:....|:...||.:.|
Mouse   318 IM--RNYSYEKLLWTTSRVLKV-----LSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWT 375

  Fly   480 -RKICGV--------SILR----------------AGETMEQAVCDVCKDIRIGKILIQTNLKTG 519
             |.:..|        |:|:                |..|:....|:..|:    |.|:..|  :|
Mouse   376 LRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKN----KTLVTQN--SG 434

  Fly   520 EPELYYLRLPKDIKDYKVILMDATVATGAAAMMAIRVLLDHDVPEDNIILASLLMAEIGVHSIA- 583
            ...|.:..|....||      |.|    ..|:.|:|.|.... ||          ||:..:|:.
Mouse   435 VEALIHAILRAGDKD------DIT----EPAVCALRHLTSRH-PE----------AEMAQNSVRL 478

  Fly   584 -YAFPKV 589
             |..|.:
Mouse   479 NYGIPAI 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k01209	NP_725672.2	UMPK	188..387	CDD:238981	43/229 (19%)
		UPRTase	417..620	CDD:434124	45/212 (21%)
Jup	NP_034723.1	CTNNAbd_CTNNB1-like	73..142	CDD:459249	17/91 (19%)
		Adaptin_N	<120..>289	CDD:396262	35/204 (17%)
		Interaction with DSC1 and DSG1. /evidence=ECO:0000250	132..297		35/185 (19%)
		armadillo repeat	144..169	CDD:293788	7/26 (27%)
		armadillo repeat	186..212	CDD:293788	5/37 (14%)
		armadillo repeat	221..253	CDD:293788	7/32 (22%)
		Arm	221..253	CDD:425727	7/32 (22%)
		armadillo repeat	261..297	CDD:293788	7/35 (20%)
		ARM 5	298..341		14/66 (21%)
		armadillo repeat	305..338	CDD:293788	11/56 (20%)
		PLN03200	<328..>658	CDD:215629	38/190 (20%)
		ARM	341..381	CDD:214547	7/39 (18%)
		ARM 6	342..381		7/38 (18%)
		armadillo repeat	345..380	CDD:293788	6/34 (18%)
		ARM 7	383..420		4/36 (11%)
		armadillo repeat	393..418	CDD:293788	3/24 (13%)
		ARM 8	423..464		15/56 (27%)
		armadillo repeat	426..464	CDD:293788	14/49 (29%)
		ARM 9	470..510		4/16 (25%)
		armadillo repeat	470..508	CDD:293788	4/16 (25%)
		ARM 10	512..551
		armadillo repeat	515..572	CDD:293788
		Interaction with DSC1. /evidence=ECO:0000250	574..661
		armadillo repeat	577..611	CDD:293788
		armadillo repeat	618..652	CDD:293788