Protein Alignment cnk and Tex16

DIOPT Version :10

• Sequence 1: NP_725671.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: NP_001404192.1
• Gene: Tex16 / 83556
• MGIID: 1890545
• Length: 2450
• Species: Mus musculus
• Alignment Length: 1786
• Identity: 339/1786 - (18%)
• Similarity: 573/1786 - (32%)
• Gaps: 587/1786 - (32%)

  Fly    10 TPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVENLRNF 74
            :|.:|..|::.||.|...|...|...||.|..||||...:|.:||::|..||:|:|:||..:|
Mouse    17 SPTEVRMWVEDLDYSFLSYGEIFESAEINGERLLNITRKQLIDLGIVRTDHQDILLQAVARIR-- 79

  Fly    75 HYHLKNDNLQFMALHVATAAKNLHRELARNHAESTKIDTRILHDITRTIATL------KPLVGSL 133
                |....:..|:.  ...:|:.:...|...||.:::    |.|.|.:.|:      :.|.|::
Mouse    80 ----KKGKAEEQAMR--REDQNIKKMPTRFGKESEQLE----HAIDRVLFTISERRLARSLHGTI 134

  Fly   134 ERTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLANFVIQDISDPMV 198
            |..|.           ::|...|:|..||......|:..|.  .......:|.|.:|
Mouse   135 EHPPH-----------SILTATLDLVNIASTILNILERPPF--DCMSEFSSLKNHLI-------- 178

  Fly   199 LQPASLNLVTLKKRESELGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINYQTVVGWQ 263
                  |.:||.|..||
Mouse   179 ------NHITLLKHFSE------------------------------------------------ 189

  Fly   264 HRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARWAAQMPSPRAAF-LTL 327
             ::.|.|..|:  |::...|   ..|||...|...|..||..:|.:......:..|||... :|.
Mouse   190 -QSDLTHENES--DIIDMCK---GVTKMCHYIISLPPDLPKPERQIPRPAHREDRSPRVQVPITT 248

  Fly   328 DTEQLATGGTGSAVPDPS-KSLSSE-KREVLTKANPV-------SSASDSDSSCSDIPTPTDPKL 383
            :.|::::.....|...|| :.||.. ....|:...||       ...|:|.||...:..|:|...
Mouse   249 EPERVSSSVKRKADNTPSIQHLSMPMTTSALSYGPPVQYTSVQNQRLSESYSSSPRVEFPSDEGA 313

  Fly   384 AAREIRLYYPKPRALLQRRN---TICGCEY------LSLKNSDL-VVPSWHERKPGIGSPTNCDP 438
            ...|....| |....:|..:   |:.|..|      |:|..||. ::.|..|:         |..
Mouse   314 FTLECDKGY-KSETEIQYTDAFETLGGSFYYKTLQDLTLIESDTPLMDSGSEK---------CVI 368

  Fly   439 GSPSIRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQRE-FLVDRYK 502
            .|.|  |:.:...:.||..::.:..:.:..|:.::|:.|           ..||::. |..:.|:
Mouse   369 DSDS--DRGVVSDFELEEQSKDSGSVTLGLDSDSEKSPR-----------DSDSRKHLFKAEPYQ 420

  Fly   503 PGVSKVVRFDAKEDYVMKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCKTENAEELLEA 567
            .....|      || :.|..|.:..:|...:|:.....:...|.|.:||      ..|::.|.::
Mouse   421 LDSVSV------ED-LTKTGKHLLRIEQYQMESGALKHWMTSGSEKSLE------DSNSQRLSDS 472

  Fly   568 INLATKGQDLPLAEAINMPLLQQGRRGRLD----------KSHSTPAYDNSGEESDTPPAIEPRK 622
            .|...|.::..:|.| ::..|.:..:.:::          :|:|..::...|.
Mouse   473 DNERQKEENFQMASA-SVQSLMESEKTKMESESLWMISDSESYSVDSHTEKGR------------ 524

  Fly   623 EFLLVTPPAPPPRPRKQREMTPPAVPPPPPKPASMQPASSITSISIPVPVPVPAAVDPSEISELH 687
                                                  :|::.|::       ..:|.:|
Mouse   525 --------------------------------------ASVSKINL-------IQIDETE----- 539

  Fly   688 TPSKSRTLTLKKKHSLM---AKRRNTNLKLLGTGDIQGHLYRRKKNHRGVTYWARIYFVMLDTIL 749
               |.||     |..||   ::..||:      .|.:|         ..:...|..||:...|.
Mouse   540 ---KPRT-----KRYLMESDSEPSNTD------SDSEG---------CELASAAVKYFIATKTF- 580

  Fly   750 YGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHA----------FKVYHTAKSF-----YFAAES 799
                 :||:::|.   .|..:.|.::.::|...:          .|...|.||.     ..||..
Mouse   581 -----QQSSASSQ---FPKDSWSASRTINSDSESPVMSSDSMKYMKKAETCKSTCNLERLKAAHK 637

  Fly   800 LDALNQWVDFLRQASLKVPPSTGSKGGGDAKDLYSEN----DSSGEECDALVIQNLSTPSPQGNK 860
            .::|..|:|..|                  |.|.|:|    ||||:...:.::...|....||:.
Mouse   638 SESLQDWLDAKR------------------KQLDSDNAGYWDSSGKYQFSSIVPQESVGKRQGDL 684

  Fly   861 ESMSMS---MTLSGGTPPSSAPIKHERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQ-------- 914
            ::...|   ..:...:....|...:||...|...| ....|:.....:....:..|:
Mouse   685 QTFQHSTEKKEVGSSSDKHQAQFGNERDQSDPKSK-RYLIKTETGLDNEGFQMDEEREGCLVESD 748

  Fly   915 YRSYRKVPGGSFGIQIGA-----NTPGYHDPAMPPTQIPPLVGPK-------------------L 955
            :|...:........::||     ..||:..|.:.|   |.|...|                   |
Mouse   749 FRDSEREAHLLEAHRLGARKKENRPPGFWRPIILP---PKLAQDKKTEEQKSVQQKDNRVSRIQL 810

  Fly   956 SRSSSRSSVVSGTESAVSLSASILG------------PPASPAPT-------------------- 988
            :|..|....|...|::.|||...|.            .|.||..|
Mouse   811 TRYKSEDKNVRFEEASSSLSDKPLSQEKLKKKHSYSFSPDSPTFTDEKHHRKASLKISGYKRQCK 875

  Fly   989 ----------------PTPTATPTSLQHQSS-EESPSQSQSQSPSSKSSLKKAPFN--------- 1027
                            |.|.::.|...:.|| .:||:....:|.:.|.|.:...::
Mouse   876 EYRYPHSCESLKYQISPIPLSSETCTSNVSSFVDSPTSKSPKSVTRKKSRRSITYSPEQGSQKCT 940

  Fly  1028 --FLHASNPN----LVEFDFHTSKTLLPKMSVGNTLDH------GHNIQGFVTLKDLMLRKQEEE 1080
              |:..||.:    |:..|...|.:.|.    |....|      ...|:.|.|.::..| .|..:
Mouse   941 RCFMEISNSSYHKCLINSDDSDSDSPLH----GQISSHSKYSLRSKTIRHFKTSRNRPL-SQSLD 1000

  Fly  1081 AQEMYNNRVHLGVEKHKHA-------RTESTASQQSAMSSSVTKPLEKLPK-------------- 1124
            .|....:|..|..|..||:       ..||.||.|:...||||..:.|..|
Mouse  1001 PQHSVVSRCSLHREDSKHSIDSTSYLHCESCASLQNLKGSSVTHTISKTTKKIMGQHSTHGHISG 1065

  Fly  1125 ----IQSVS---LPKTPDYEISFKPDDESIKRTRTKEGQKL--RDFGYELICGDEPSTSSISRQE 1180
                .||.|   |...|..|.:....|.:||.....|.:.|  .|..:|    ||.:|...:..|
Mouse  1066 PVRLSQSESKFNLTAQPQNEDTPDVSDRNIKAEANVEDKLLYKDDTDHE----DETNTEDETDGE 1126

  Fly  1181 HHHHHHHHQHHLQHVQQQQQLQHQQTQQQHSSKAKHFLRSQQLQLSSFLHKNSSGGSGKSSGSGA 1245
                                 ....|:.:.....                |:......||...|:
Mouse  1127 ---------------------DETDTEDEDEDDT----------------KDKKDPKDKSDPDGS 1154

  Fly  1246 DQKKSKGKSSGDRRFPFSKHSTGSAGSGCGP-----GHAMTMTLPLNKKSKSNHALDGAVGNGVT 1305
            |.|....:::.|..  .....:||:|...||     |.:..:|   :.||:|:..:|.|..:.|.
Mouse  1155 DPKDGNSENNTDSN--NGSQPSGSSGPTGGPDSSNDGDSKNVT---DHKSESDPTIDNATNSDVN 1214

  Fly  1306 IIGSGSSIKKSQTYNQDLRDKIVGTKYDAHRKNSAPIPIFSKLSISGGT-PAKPSKENRFLGSPL 1369
            :   ..|..::.|.|.|....:  .:|..|..|:         ...|.| ||..:|.
Mouse  1215 L---KYSTDETCTNNLDNASDL--AEYFNHHNNA---------DFKGRTNPASGNKT-------- 1257

  Fly  1370 LHRTLFGHHHHQQQAVTPPSSADPDCDQEIFSQITLPTHNQAGYRSYRGPGILTTSTTNLCSSEG 1434
              ||:..:........|.|.:             |:.....|...:.|   :|:.|..|.....|
Mouse  1258 --RTILDYISGSNNEDTGPRN-------------TMIKEKIAYSENIR---LLSNSYQNNVIKNG 1304

  Fly  1435 LQPPLPPAPPPPVNTSRQREEEQAEATISECAAT---------PKVSSSGSVDSKAATPDYPNME 1490
            .:   |.:.|.|.|:....::..:.:.|:...||         .|.:|:......||...|.::.
Mouse  1305 SE---PSSNPSPQNSYGLPKDLDSNSNINPSNATNNTVNPNYGAKSTSTAIYKKTAALNYYSDIN 1366

  Fly  1491 CPPVFEPEI------------------------YSLSDTSLSRIVMRTPS--SSGATSATASTTT 1529
            ....|..|:                        ::::....:.::..|.:  |..|:..|:...|
Mouse  1367 DVTGFTYEVRSSFVVNSNYFDRKKYAGRLSFALHTINAIDTNNVITCTSAVRSKFASEKTSVLDT 1431

  Fly  1530 TNNN------------NNNNNTNNNTNTNSS 1548
            .::.            :.|.||.|:.|.|.|
Mouse  1432 KHSPRFSRFRSFNVIISPNYNTKNSQNANKS 1462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_725671.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	26/63 (41%)
		CRIC_ras_sig	82..165	CDD:463138	18/88 (20%)
		PDZ_CNK1_2_3-like	203..283	CDD:467230	10/79 (13%)
		PH_CNK_insect-like	720..810	CDD:270135	20/104 (19%)
Tex16	NP_001404192.1	SAM_superfamily	17..79	CDD:472832	25/61 (41%)
		MSCRAMM_ClfA	<1158..1340	CDD:468110	44/229 (19%)
		PH-like	1859..1957	CDD:473070