DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cnk and ipcef1

DIOPT Version :9

Sequence 1:NP_001286524.1 Gene:cnk / 36952 FlyBaseID:FBgn0286070 Length:1557 Species:Drosophila melanogaster
Sequence 2:XP_021324199.1 Gene:ipcef1 / 767791 ZFINID:ZDB-GENE-060929-172 Length:407 Species:Danio rerio


Alignment Length:459 Identity:111/459 - (24%)
Similarity:163/459 - (35%) Gaps:160/459 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   707 RRNTNLKLLGTGDIQGHLYRRKKNHRGVT--YWARIYFVMLDTILYGFRSKQSTSASLVIFLPGF 769
            ||..::|.||.||.||.||:||:: :|:.  .|.:.:||:....||.:.|..:..|...|.|..|
Zfish    64 RRRVSVKDLGQGDCQGWLYKRKES-KGLLGWKWKKFWFVLKKCSLYWYTSDMAEKAEGYINLRDF 127

  Fly   770 TVSLAKEVHSKPHAFKVYHT-AKSFYFAAESLDALNQWVDFLRQASLKVPPSTGSKGGGDAKDLY 833
            |:..|.|. .|..|.|..|. ..:.||||||:..:|:|:..|.|||.:..|:..:.|     :.|
Zfish   128 TIEQATEC-KKKFAMKASHLHVLTLYFAAESMKDMNKWLAKLTQASNEPEPTDSTNG-----ECY 186

  Fly   834 SENDSSGEECDALVIQNLSTPSPQGNKESMSMSMTLSGGTPPSSAPIKHERGYLDSFRKFTNTFK 898
            || :|..|:.:.:.::.:...:|.          :|.|..||                      .
Zfish   187 SE-ESDDEDDEEMCVEYMDQLTPG----------SLHGCLPP----------------------P 218

  Fly   899 SSAAKPSSDIPVPTEQYRSYRKVPGGSFGIQIGANTPGYHDPAMPPTQIPPLVGPKLSRSSSRSS 963
            .|::.|..|                                       :.|||          ||
Zfish   219 RSSSSPFQD---------------------------------------VIPLV----------SS 234

  Fly   964 VVSGTESAVSLSASILGPPASPAPTPTPTATPTSLQHQSSEESPSQSQSQ-----SPSSKS---- 1019
            |.|.||                    |.:|...|.|..||||.|.....|     .|:|..    
Zfish   235 VCSRTE--------------------TQSADSESWQEISSEEDPILKIQQCKGNDGPASDEMEML 279

  Fly  1020 --SLKKAPFNFLHASNPNLVEFDFHTSKTLLPKMSVGNTLDHGHNIQGF---VTLKDLMLRKQEE 1079
              .||:|..:...|..| ..:.||.:|  .:.:....|..|..|.|:..   :..|:..|:..|:
Zfish   280 YLHLKEASLSPTGALQP-FTKRDFRSS--FIRRCKDENINDKLHLIRALNSTLKAKEADLQAIEQ 341

  Fly  1080 EAQEMYNNR--------------VHLGVEKHKHARTESTASQQSAMSSSVTKPL-EKLPKIQSVS 1129
            ...|...||              ..:| ||||               |.|.||: :..|:.||:.
Zfish   342 VLSEPSLNRSKYRQWRDANVLLLQEIG-EKHK---------------SDVEKPMVQTRPQRQSLY 390

  Fly  1130 LPKT 1133
            .|.|
Zfish   391 GPNT 394

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cnkNP_001286524.1 SAM_CNK1,2,3-suppressor 6..74 CDD:188910
SAM 7..74 CDD:197735
CRIC_ras_sig 82..165 CDD:287501
PDZ_signaling 206..283 CDD:238492
PH 720..814 CDD:278594 34/96 (35%)
PH_CNK_insect-like 720..810 CDD:270135 32/92 (35%)
ipcef1XP_021324199.1 PH_CNK_mammalian-like 63..176 CDD:269962 43/113 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170594410
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1121556at2759
OrthoFinder 1 1.000 - - FOG0001221
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.850

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