DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cnk and 4933403O08Rik

DIOPT Version :9

Sequence 1:	NP_001286524.1	Gene:	cnk / 36952	FlyBaseID:	FBgn0286070	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	XP_011246010.1	Gene:	4933403O08Rik / 71030	MGIID:	1918280	Length:	813	Species:	Mus musculus

Alignment Length:	803	Identity:	161/803 - (20%)
Similarity:	250/803 - (31%)	Gaps:	319/803 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   570 LATKGQDLPLAEAINMPLL--QQGRRGRLDKSH-STPAYDNSGEESDTPPAIEPRKEFLLVTP-- 629
            :..:..::|:..:...|..  :.||..|.::.: :.||.|.         |:.| ::.|.|.|
Mouse     4 ITRRSSEVPVWRSAEAPTWGPEGGRPARFERGYAANPAKDF---------AVRP-EQGLTVIPAR 58

  Fly   630 -----PAPPPRPRKQRE--------MTPPAVPPPPPKPASMQPASSITSISIP------------ 669
                 ||.....|..||        .|.....|....|.|....||...|::.
Mouse    59 GRSLSPARGYTDRYGRERAVSLARGYTERQASPRTLSPFSTHAVSSAQKITLQAARRPPMRHEEE 123

  Fly   670 --VPVPVPAAVDPSEISELHTPSKSRTLTL-----------------KKKHSLMAKRRNTNLKL- 714
              |...:...|.|:|..:..|...:|..|.                 :.:.||:....|..:|.
Mouse   124 FLVGAAMGLTVKPAEGYDNETSQSARLYTQNIYDDDNDDEDDDDDVDENESSLIMNFINCFMKAK 188

  Fly   715 --------------------------------------LGTGDIQGHLYRRKKNHRGVTY--WAR 739
                                                  ||.|..:|.|: .|:..||::.  |.:
Mouse   189 AQNWIDCSWFRRLLPTFFSEEDRHSWPKNRFCAIACTELGHGKCEGWLW-HKRPSRGISLFSWKK 252

  Fly   740 IYFVMLDTILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYHT-AKSFYFAAESLDAL 803
            .:|::..:.||.|.....|.|...|:||.|.:.||.... :.|||:..|. .|.||||...||.:
Mouse   253 YWFILKHSTLYWFSHLNDTKADGFIYLPEFRIDLAPHCR-RDHAFQATHARIKDFYFAGTCLDEM 316

  Fly   804 NQWV---------------------------------------------DFLRQAS--LKVPPST 821
            |.||                                             |:.::|:  :.|.|:.
Mouse   317 NYWVCQTIKLAFGSSFGDTAANAEYRLASTSVYAKCLVALKRNFPVIWCDYCQEATTIVSVNPNF 381

  Fly   822 GSKGGGDAKDLY----------SENDSSGEECDALVIQNLS----TPSPQG--NKESMSMSMTLS 870
            ..:...:..|.:          .|.|...::      |||:    .|:|:|  .::...|:..:.
Mouse   382 QYRRTQNISDEFIYFRPINAENRERDRKQKQ------QNLTLVTQQPTPEGIHQRDLGLMNQVVI 440

  Fly   871 GGTPPSSAPIKHERGYLDSFRKFTNTFKSSA-AKPSSD-------IPVPTEQYRSYRKVP----- 922
            ..|||                 .|...:|:| .||.:.       ||:      .|..||
Mouse   441 ATTPP-----------------LTKELESTALVKPKTSGLLRIEKIPI------KYLWVPEFQRL 482

  Fly   923 -----------GGSFGIQIGANTPGYHDPAMPPTQIPPLVGPKLSRSSSRSSVVSGTESAVSLSA 976
                       |....|.: |..||..:  :..|:||.|                .....|.|.|
Mouse   483 EVTGIASPEERGKGTAILV-AGVPGKEE--LDDTEIPTL----------------HFTGFVHLEA 528

  Fly   977 SILGPPASPAPTPTPTATPTSLQHQSSE--ESPSQ-----SQSQSP--------SSKSSLKKAPF 1026
            .|  ...||:...:...||.:|..:|.|  |||..     ::|..|        .|.:.|.:||.
Mouse   529 LI--NKCSPSSEYSRPGTPGNLWMESPENAESPGSDDMEVARSMYPFRERSIFRRSWAELLEAPL 591

  Fly  1027 NFLHASNPNLVEFDFHTSKTLLPKMSVGNTLDHGHNIQGFVTLKDLMLRK---QEEEAQEMYNNR 1088
            |          ....|..:|           :|.||.:.    :|:...|   |||      |..
Mouse   592 N----------SEGLHIIQT-----------EHIHNEEN----RDMGCNKLTLQEE------NQV 625

  Fly  1089 VHLGVEKHKHARTESTASQQSAMSSSVTKPLEKLPKIQSVSLPK----------TPDY-----EI 1138
            :.|..::|..|       .|........:|  ||.:.:|.|||:          ||::     |.
Mouse   626 IPLPKDQHFQA-------LQGPFPLLPERP--KLQRQRSRSLPRNSEVGGQYLNTPEFKGSAEET 681

  Fly  1139 SFKPDD------ESIKRTRTKEG 1155
            .|.|.|      |:||...:.||
Mouse   682 PFFPRDHNLLTEENIKERHSMEG 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910
		SAM	7..74	CDD:197735
		CRIC_ras_sig	82..165	CDD:287501
		PDZ_signaling	206..283	CDD:238492
		PH	720..814	CDD:278594	33/141 (23%)
		PH_CNK_insect-like	720..810	CDD:270135	33/137 (24%)
4933403O08Rik	XP_011246010.1	PH-like	222..320	CDD:388408	33/99 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848870
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1738
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830