DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cnk and Samd3

DIOPT Version :9

Sequence 1:	NP_001286524.1	Gene:	cnk / 36952	FlyBaseID:	FBgn0286070	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	NP_001165587.1	Gene:	Samd3 / 685940	RGDID:	1587834	Length:	273	Species:	Rattus norvegicus

Alignment Length:	246	Identity:	47/246 - (19%)
Similarity:	91/246 - (36%)	Gaps:	70/246 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVENLRN 73
            |:.|||..|:  :::::...:..|.::|:.|.|||.:....::.| :.:||||.::::.::..:.
  Rat     4 WSVDQVCKWL--VEKNLGELVPRFQEEEVSGTALLALNDRMVQQL-VKKIGHQAVLMDFIKKYKQ 65

  Fly    74 FHYHLK--NDNLQFMALHVATAAKNLHRELA-RNHAESTK----------IDTRIL--------- 116
            .:..||  ..:.:...|.:..||....|.|: .:|.:.|.          ||.|:|
  Rat    66 SNQGLKPSGGSTETSLLTLVQAAPEHERNLSPTSHGDQTSLYPAVLDNRLIDQRVLKQRRNVKHV 130

  Fly   117 -------------------HDITRTIATLK----------------PLVGSLERTPFRKQEMYRE 146
                               :|:...:|..|                .:...||.:.:...:.|.:
  Rat   131 LARHKALHWTKSYVLPEFPYDVKCVLAEQKRPDHSMRIRIIEFLQADMTKYLEGSLYPTTQQYND 195

  Fly   147 YCGNVLK---------CGLELATIAHRDRFALQPVPAIRQSAERLENLANF 188
            ....:|:         ||..|...|.:|||.....| |....:.:.|...|
  Rat   196 VVNALLQAHPFLDEDGCGFFLWKRALKDRFKYVRRP-IEDDEQVMRNKCKF 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	16/64 (25%)
		SAM	7..74	CDD:197735	16/64 (25%)
		CRIC_ras_sig	82..165	CDD:287501	22/146 (15%)
		PDZ_signaling	206..283	CDD:238492
		PH	720..814	CDD:278594
		PH_CNK_insect-like	720..810	CDD:270135
Samd3	NP_001165587.1	SAM	1..66	CDD:197735	16/64 (25%)
Samd3	NP_001165587.1	SAM_superfamily	1..65	CDD:301707	16/63 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352476
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930