Protein Alignment cnk and Cnksr2

DIOPT Version :10

• Sequence 1: NP_725671.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: NP_001106837.1
• Gene: Cnksr2 / 59322
• RGDID: 708454
• Length: 1032
• Species: Rattus norvegicus
• Alignment Length: 1290
• Identity: 297/1290 - (23%)
• Similarity: 482/1290 - (37%)
• Gaps: 368/1290 - (28%)

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            :::|:|.||.||:||||:.::.|:..|.:::|.|..||.|...|||:||:.||||||::||||:.
  Rat     8 VSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDL 72

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELA----RNHAE---STKIDTRILHDITRTIATLKP 128
            |...:|.|:.:||:.::..:..:||||...:.    ..|.:   |.|:....|..:...|...|.
  Rat    73 LCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKS 137

  Fly   129 LVGSLERTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLANFVIQDI 193
            |:..|:|:||.....|.....||::..|||.||..:|....:....|....:.|..:.:.:|...
  Rat   138 LLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLS 202

  Fly   194 SDPMVLQPASLNLVTLK--KRESELGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINY 256
            |||:|.|.|.|.::.|.  |....||..|:|:|:|:|.:|....||||....||..|||::|:|:
  Rat   203 SDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNH 267

  Fly   257 QTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARW---AAQMP 318
            |||||||.:.::..|||....|:||:||||:....         ..|:..:||  ||   |.|..
  Rat   268 QTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLT---------SAPALLKNM--RWKPLALQPL 321

  Fly   319 SPRAAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDSDSSC-SDI---PTPT 379
            .||:                     |:.|       |.|.::.:|:.:..|||. .|:   |.|.
  Rat   322 IPRS---------------------PTSS-------VATPSSTISTPTKRDSSALQDLYIPPPPA 358

  Fly   380 DPKLAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGIGSPTNCDPGSPS-- 442
            :|         |.|:.    ::.|..|         .||       |...:|.|.:....||:
  Rat   359 EP---------YIPRD----EKGNLPC---------EDL-------RGHMVGKPVHKGSESPNSF 394

  Fly   443 -----------IRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQREF 496
                       :.:.::.:.|..|           .|.:|:...|.......||:.::...:..:
  Rat   395 LDQEYRKRFNIVEEDTVLYCYEYE-----------KGRSSSQGRRESTPTYGKLRPISMPVEYNW 448

  Fly   497 LVDRYKPGVSKVVRFDAKEDYV---MKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCKT 558
            :.|...|  :|:.|...:|:.:   |.|||..                     ::.....||.|.
  Rat   449 VGDYEDP--NKMKRDSRRENSLLRYMSNEKIA---------------------QEEYMFQRNSKK 490

  Fly   559 ENAEELLEAINLATKGQDLPLAEAINMPLLQQGRRGRLDKSHSTPAYDNSGEESDTPPAIEPRKE 623
            :..::..:..:.:|......|..::.|..|:|...|
  Rat   491 DTGKKSKKKGDKSTSPTHYSLLPSLQMDALRQDIMG----------------------------- 526

  Fly   624 FLLVTPPAPPPRPRKQREMTPPAVPPPPPKPASMQPASSITSISIPVPVPVPAAVDPSEISELHT 688
                                                          .|||........:.|.|..
  Rat   527 ----------------------------------------------TPVPETTLYHTFQQSSLQH 545

  Fly   689 PSKSRTLTLKKKHSLMAK-RRNTNLKLLGTGDIQGHLYRRKKNHRGVTY----WARIYFVMLDTI 748
            .||.     |.|.::..| :|..:.|.||.||.:|.|:::|.   ..:|    |.:.:||:.|..
  Rat   546 KSKK-----KNKGAIAGKSKRRISCKDLGRGDCEGWLWKKKD---AKSYFSQKWKKYWFVLKDAS 602

  Fly   749 LYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYH-TAKSFYFAAESLDALNQWVDFLRQ 812
            ||.:.:::...|...|.||.|.:..|.|...| :|||..| ..||||||||.||.:|:|::.:..
  Rat   603 LYWYINEEDEKAEGFISLPEFKIDRASECRKK-YAFKACHPKIKSFYFAAEHLDDMNRWLNRINM 666

  Fly   813 ASLKVPPSTGSKGGGDAKDLYSENDSSGEECDALVIQNLSTPSPQGNKESMSMSMTLS------- 870
            .:.........|   ..:|.:||:|.  ||.|........:|.|..:......||:.:
  Rat   667 LTAGYAERERIK---QEQDYWSESDK--EEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAK 726

  Fly   871 ----GGTPPSSAPIKHERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQYRSYR---KVPGGSFGI 928
                ..|..|.:...||     .||:  ....|||..|   |.....|.||::   :.|..|.|:
  Rat   727 HSRLSSTETSQSQSSHE-----EFRQ--EVTGSSAVSP---IRKTASQRRSWQDLIETPLTSSGL 781

  Fly   929 QI--------------GANTPGYHDPAMPPTQ---IPPLVGPKLSRSSSRSSVVSGTESA----- 971
            ..              .|.:|.:...:..|||   :....||.....|.|..|::|....
  Rat   782 HYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFT 846

  Fly   972 ----VSLSASILGPPASPAPTPTPTATPTSLQHQSSEESPSQSQSQSPSSKSSLKKAPFNFLHAS 1032
                ...:...|..|.| |..|.....|..::.:..||..                      .|:
  Rat   847 LPRDSGFNHCCLNAPVS-ACDPQDDIQPPEVEEEEEEEEE----------------------EAA 888

  Fly  1033 NPNLVEFDFHTSKTLLPKMSVGNTLDHGHNIQGFVTLKDLMLRKQEEEAQEMYNNRVHLGVEKHK 1097
            ..|:.|.:.:..:.|      |:            :|:||....:|.....:..:|:...:|
  Rat   889 GENIGEKNENREEKL------GD------------SLQDLYRALEEASLSPLGEHRISTKIE--- 932

  Fly  1098 HARTESTASQQSAMSSSVTKPL--EKLPKIQSV-SLPKTPDYEISF------KPDDESIKRTRTK 1153
                     .:.:.......|:  |||.:::.: |..|..:.|::.      .||      ..:|
  Rat   933 ---------YKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPD------LTSK 982

  Fly  1154 EGQKLRDFGYEL---ICGDEPS-------------TSSISRQEHHHHHHHHQHHL 1192
            |.|:.:....:|   ||.:..|             |||::     |.|.:.:.|:
  Rat   983 EFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLT-----HTHSYIETHV 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_725671.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	33/67 (49%)
		CRIC_ras_sig	82..165	CDD:463138	25/89 (28%)
		PDZ_CNK1_2_3-like	203..283	CDD:467230	35/81 (43%)
		PH_CNK_insect-like	720..810	CDD:270135	34/94 (36%)
Cnksr2	NP_001106837.1	SAM_CNK1,2,3-suppressor	8..76	CDD:188910	33/67 (49%)
		CRIC_ras_sig	84..176	CDD:463138	26/91 (29%)
		PDZ_CNK1_2_3-like	214..294	CDD:467230	34/79 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	324..349		9/52 (17%)
		CNK2_3_dom	339..>487	CDD:461979	34/210 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	480..509		4/28 (14%)
		PH_CNK_mammalian-like	559..672	CDD:269962	40/116 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..766		23/95 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	866..900		7/55 (13%)