DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cnk and si:ch211-26b3.4

DIOPT Version :9

Sequence 1:	NP_001286524.1	Gene:	cnk / 36952	FlyBaseID:	FBgn0286070	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	XP_021327272.1	Gene:	si:ch211-26b3.4 / 568768	ZFINID:	ZDB-GENE-081104-60	Length:	1031	Species:	Danio rerio

Alignment Length:	1277	Identity:	307/1277 - (24%)
Similarity:	474/1277 - (37%)	Gaps:	392/1277 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            |::|:|.||.||:||||:.:..|:..|.:::|.|..||:|...|||.||:.||||||::||||:.
Zfish     8 ISKWSPKQVLDWMKGLDDCLLQYMRTFEREQITGEQLLHITHQELEELGVTRIGHQELILEAVDL 72

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELA---RNHAESTKIDTRILHDITRTIATL----KP 128
            |...:|.|:.:||:.::..:..:||||...:.   |......::..|:.:|...::..|    |.
Zfish    73 LCALNYGLETENLRTLSHKLNASAKNLQNFITGRRRGGHYDGRVSRRLPNDFLTSVVDLIGAAKN 137

  Fly   129 LVGSLERTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLANFVIQDI 193
            |:..|:|:||.....|.....|:::..|||.||..:|....:....|....:.|..:...:|...
Zfish   138 LLAWLDRSPFVSVSEYSVLKNNIVQLCLELTTIVQQDCTVYETENKILHVCKTLSGICEHIISLS 202

  Fly   194 SDPMVLQPASLNLVTLKK-RESE-LGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINY 256
            ||.:|.|.|.|.:|.|.. ..|| ||..|:|:|:|:|.:|....||||....||..|||::|:|:
Zfish   203 SDSLVSQSAHLEVVHLTNVMPSEGLGMYIKSTYDGLHVITGTTENSPADQCKKIHAGDEVIQVNH 267

  Fly   257 QTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARWAAQMPSPR 321
            |||||||.:.::..|||....|:||:||||::|  .|.       .|:..:|  |||
Zfish   268 QTVVGWQLKNLVNCLREDPSGVILTLKKRPQNT--LGS-------TPALLKN--ARW-------- 313

  Fly   322 AAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDSDSSCSDIPTPTDPKLAAR 386
                                                  .|::....|.|.||..|||
Zfish   314 --------------------------------------KPLALQPLSTSPCSGSPTP-------- 332

  Fly   387 EIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGIGSPTNCDPGSPSIRDKSISFG 451
                    |..|        |...||               ||:.:     ||...:...|..:|
Zfish   333 --------PSTL--------GSVGLS---------------PGVDT-----PGGHDVFILSPVYG 361

  Fly   452 YGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQREFLVDRYKPGVSKVVRFDAKED 516
            :..|...|..  .|:.|..|                               ||
Zfish   362 HREEDLDRGG--FGVFGSDS-------------------------------PG------------ 381

  Fly   517 YVMKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCKTENAEELLEAINLATKGQDLPLAE 581
            |.::.|        .:...:.|:...:.|....|.  |..:|....:|.: :::.|:.    |||
Zfish   382 YYVEQE--------VLGGQYFPLLEEESGRNTGLR--RRDRTPTHSDLRQ-VSMGTEW----LAE 431

  Fly   582 AINMPLLQQGRRGRLDKSHSTPAYDNSG------EESDTPPAIEPRKEFLLVTPPAPPPRPRKQR 640
            .....:.::|.|   |...|...:.:..      ||::.......|:.......|:.|..|
Zfish   432 PQESGVYKRGSR---DSDSSLLRFLSDDRILLIQEEAEFSQRDTSRRSRKKSRNPSSPSFP---- 489

  Fly   641 EMTPPAVPPP------PPKPASMQPASSITSISIPVPVPVPAAVDPSEISELHTPSKS------- 692
             ::|..:.||      ||:             .:|.|||     |.:.:...|..:.:
Zfish   490 -ISPSMLAPPVRLDTGPPE-------------GLPFPVP-----DSNTMPHYHRAADTLRADADR 535

  Fly   693 -----------------------RTLTLKK-KHSL-MAKRRNTNLKLLGTGDIQGHLYRRKKNHR 732
                                   ||...|| |.|| .|.||....|.||.||.:|.|: :||:..
Zfish   536 YASSGLDRQAGASMRKSVHYASLRTKPKKKSKGSLSSASRRRIACKDLGHGDCEGWLW-KKKDAT 599

  Fly   733 G--VTYWARIYFVMLDTILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYH-TAKSFY 794
            |  ...|.:.:||:.|:.||.:.::....|...|.||.|.:..|.|...| ||||..| ..|||:
Zfish   600 GYFTQKWKKYWFVLKDSNLYWYTNQNDEKAEGFISLPEFRIDRAIECRRK-HAFKACHPKIKSFF 663

  Fly   795 FAAESLDALNQWVDFLRQASLKVPPSTGSKGGGDA-----KDLYSENDSSGEECDALVIQNLSTP 854
            ||.:.|:.:|:|::.|..|::...|.       |.     :|.:||:|.  :|.|.
Zfish   664 FATDHLEEMNRWMNRLGLAAIGYTPD-------DPVPRPDEDYWSESDQ--DEVDG--------- 710

  Fly   855 SPQGNKESMSMSMTLS-------GGTPPSSAPIKHERGYLDSFRKFTNTFKSSAAKPS-SDIPVP 911
                       ||||.       ..|..|::|.. ||.:...     :||..|:|:.| |.....
Zfish   711 -----------SMTLKQEATYHHNPTATSTSPFP-ERHFSSG-----STFSHSSAEESHSSCRSS 758

  Fly   912 TEQYRSYRKVPGGSFGIQIGANTPGYHDPAMPPTQIPPLVGPKLSRSSSRSSVVSGTESAVSLSA 976
            ..:.||::.:      |:....:.|.|.......:.|.|:.|...|.:             :|.|
Zfish   759 HRERRSWQDL------IETPLTSTGLHYLQTAEEEEPGLLSPDQLRQA-------------TLPA 804

  Fly   977 SILGPPASPAPTPTPTATPTSLQH----QSSEESPSQSQSQSPSSKSSLKKAPFNFLHASNPNLV 1037
            ....|.....|.|...:..:..:|    |.|:..|....:....|..|.:.
Zfish   805 QRRRPLERDGPFPLTDSEESRPRHHTHKQRSQSLPRHRDTHGGHSHRSTRT-------------- 855

  Fly  1038 EFDFHTSKTLLPKMSVGNTLDHGHNIQGFVTLKDLMLRKQEEEAQEMYNNRVHLGVEKHKHARTE 1102
              ..||..||.|:       .|.|                ||:.:|          |:.||.|..
Zfish   856 --HMHTHGTLRPR-------THLH----------------EEDEEE----------EEEKHVRKA 885

  Fly  1103 STASQQS-AMSSSVTKPLEKLPK-IQSVSL-------PKT-PDYEISF--KPDD----ESIKRTR 1151
            |:...:| ..:|..|..|::|.| ::..||       |.| .::..||  :.:|    |.:.|.|
Zfish   886 SSRRPESDEKASDGTDGLQELYKSLEQASLSAFGQQRPSTKQEFRRSFIKRSNDPATNERLHRIR 950

  Fly  1152 -------TKEGQKLRDFGYELICGDEPSTSSISRQEHHHHHH 1186
                   .|||    |........|:|..:|...:|....:|
Zfish   951 VLRSTLKAKEG----DLSIISQVLDDPCLTSRKFREWKQRNH 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	34/67 (51%)
		SAM	7..74	CDD:197735	33/66 (50%)
		CRIC_ras_sig	82..165	CDD:287501	23/89 (26%)
		PDZ_signaling	206..283	CDD:238492	36/78 (46%)
		PH	720..814	CDD:278594	33/96 (34%)
		PH_CNK_insect-like	720..810	CDD:270135	32/92 (35%)
si:ch211-26b3.4	XP_021327272.1	SAM_CNK1,2,3-suppressor	8..76	CDD:188910	34/67 (51%)
		CRIC_ras_sig	84..176	CDD:313706	24/91 (26%)
		PDZ_signaling	223..294	CDD:238492	34/70 (49%)
		DUF1170	346..>479	CDD:310926	30/200 (15%)
		PH_CNK_mammalian-like	575..686	CDD:269962	41/112 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594406
Domainoid	1	1.000	77	1.000	Domainoid score	I8761
eggNOG	1	0.900	-	-		E1_KOG1738
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	266	1.000	Inparanoid score	I3025
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1121556at2759
OrthoFinder	1	1.000	-	-		FOG0001221
OrthoInspector	1	1.000	-	-		otm25178
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12844
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.860