DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cnk and cnksr2b

DIOPT Version :9

Sequence 1:	NP_001286524.1	Gene:	cnk / 36952	FlyBaseID:	FBgn0286070	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	XP_009293705.1	Gene:	cnksr2b / 558834	ZFINID:	ZDB-GENE-030131-8048	Length:	969	Species:	Danio rerio

Alignment Length:	1175	Identity:	279/1175 - (23%)
Similarity:	434/1175 - (36%)	Gaps:	325/1175 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            ::.|:..||.||:||||:.::.|:..|.::::||..||.|...|||:||:.||||||::||||:.
Zfish     8 VSRWSTSQVVDWMKGLDDCLQQYIKNFEQEKVGGEQLLRITHQELEDLGVSRIGHQELILEAVDL 72

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELA----RNHAE---STKIDTRILHDITRTIATLKP 128
            |...:|.|:.:||:.:...:..:||||...:.    ..|.:   :.|:....|..:...||..|.
Zfish    73 LCALNYGLETENLKTLTHKLNASAKNLQNFITGRRRGGHYDGRATRKLPNDFLTSVVDLIAAAKS 137

  Fly   129 LVGSLE------RTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLAN 187
            |:..|:      |:||.....|.....||::..|||.||..:|....:....|....:.|..:.:
Zfish   138 LLAWLDRCYFFIRSPFAAVADYSMTRNNVIQLCLELTTIVQQDGTVYETENKILHVCKTLSGVCD 202

  Fly   188 FVIQDISDPMVLQPASLNLVTLKK-RESE-LGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDE 250
            .:|...|||||.|.|.|.:|.|.. |.:| ||..|:|:|:|:|.:|.....|.|....||..|||
Zfish   203 HIIALSSDPMVSQAAHLEVVQLDNIRSTEGLGMYIKSTYDGLHVITGTTEGSLADRCKKIHAGDE 267

  Fly   251 IVQINYQTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARW-- 313
            ::|:|:|||||||.:.::..||.....|.||:||||:.|..         ..|:..:||  ||
Zfish   268 VIQVNHQTVVGWQLKNLVNSLRSNPAGVTLTLKKRPQSTLT---------SAPALLKNM--RWKP 321

  Fly   314 -AAQ---MPSPRAAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDSDSSCS- 373
             |.|   .|||                 .|:|..||.:||:..|.               .||:
Zfish   322 LALQPIIPPSP-----------------SSSVATPSSTLSTPSRR---------------DSCAL 354

  Fly   374 -DI---PTPTDPKLAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGIGSPT 434
             |:   |.|.:|         |.|:...    .|....|:. :.|.||         .|......
Zfish   355 QDLYIPPPPDEP---------YTPRDDV----GNLTSNCQQ-AAKGSD---------SPNSFLDQ 396

  Fly   435 NCDPGSPSIRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQREFLVD 499
            .|....|.:.:.::.:.|..:....|            ...||             ||...:  .
Zfish   397 ECRRRFPLLDEDAVLYCYEYDQTQGP------------PPVRR-------------DSTPTY--G 434

  Fly   500 RYKPGVSKVVRFDAKEDYVMKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCKTENAEEL 564
            |.:| :|..|.::...||                             ||..:..:..:.||:
Zfish   435 RLRP-ISMPVEYNWVGDY-----------------------------EDPAKLKKEIRRENS--- 466

  Fly   565 LEAINLATKGQDLPLAEAINMPLLQQGRRGRLDKSHSTPAYDNSGEESDTPPAIEPRKEFLLVTP 629
                          |...::....::...||.....|....:..|.     ||     .:.||
Zfish   467 --------------LLRYVSEDKTEEFHTGRRSSRRSRRKSEKGGS-----PA-----HYALV-- 505

  Fly   630 PAPPPRPRKQREMTPPAVPPPPPKPASMQPASSITSISIPVPVPVPAAVDPSEISELH-TPSKSR 693
                  |..|.:|.||                  .|::.|.          ||.|.:: |..:|.
Zfish   506 ------PTLQMDMLPP------------------DSLATPT----------SETSSVYLTFDRSS 536

  Fly   694 TLTLKKKHSLMA------KRRNTNLKLLGTGDIQGHLYRRKKNHRGVTY----WARIYFVMLDTI 748
            .|:..||:.|.|      .:|..:.:.||.||.:|.|:::|.   ..:|    |.:.:.|:.|..
Zfish   537 VLSRSKKNKLRAGSLPSISKRRISCRDLGQGDCEGWLWKKKD---AKSYFSQKWKKYWVVLKDAC 598

  Fly   749 LYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYH-TAKSFYFAAESLDALNQWVDFLRQ 812
            ||.:.:::...|...:.||.|.:..|.|...| .|||..| ..|||||||::::.:|:|:..:..
Zfish   599 LYWYTNEEDEKAEGFVSLPEFNIDQASECRKK-FAFKACHPKIKSFYFAADNIEDMNRWLSLMNM 662

  Fly   813 ASLKVPPSTGSKGGGDAKDLYSENDSSGEECDALVIQNLSTPSPQG---NKESMSMSMTLSGGTP 874
            |:   ...:..|......|.:||:|....:..:...:..|.|.|..   :..|:|.........|
Zfish   663 AA---AAHSEQKRIRQDHDYWSESDHEDADHISSTTKQDSPPPPYDTYPHPTSVSPFQDSQHIRP 724

  Fly   875 PSSAPIKHERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQYRSYRKVPGGSFGIQIGANTPGYHD 939
            ||:..::       |....:.|...|.:..||.......|.||::.:      |:....:.|.|.
Zfish   725 PSTETVQ-------SRSPLSETQGGSVSSASSPGRKSASQRRSWQDL------IETPLTSSGLHF 776

  Fly   940 PAMPPTQIPPLVGPKLSRSSSRSSVVSGTESAVSLSASILGPPASPAPTP--TPTATPTSLQHQS 1002
                 .|..||        .....|.|.....|.|......|.....||.  .|..|||
Zfish   777 -----LQTLPL--------DDSVFVDSNRTVPVELRRQSTLPAQHGLPTEHFIPPTTPT------ 822

  Fly  1003 SEESPSQSQSQSPSSKSSLKKAPFNFLHASNPNLVEFDFHTSKTLLPKMSVGNTLDHG-----HN 1062
                       .||.|.                            :|.:..|.|:|.|     |
Zfish   823 -----------QPSPKP----------------------------IPALGRGETMDGGGIGSKH- 847

  Fly  1063 IQGFVTLKDLMLR--------KQEEEAQEMYNNRVH---LGVEKHKHARTESTASQQSAMSSSVT 1116
             :.|...:|..|.        .:..:||..:...||   .|.|:.:..:.:|......|:..|..
Zfish   848 -RSFTLPRDSGLHAILAASSAAEHGDAQRYHLGHVHSRDTGGERERRHQADSLVDLYRALERSSL 911

  Fly  1117 KPLEK 1121
            .|:.:
Zfish   912 SPVNE 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	32/67 (48%)
		SAM	7..74	CDD:197735	32/66 (48%)
		CRIC_ras_sig	82..165	CDD:287501	25/95 (26%)
		PDZ_signaling	206..283	CDD:238492	33/78 (42%)
		PH	720..814	CDD:278594	29/98 (30%)
		PH_CNK_insect-like	720..810	CDD:270135	29/94 (31%)
cnksr2b	XP_009293705.1	SAM_CNK1,2,3-suppressor	8..76	CDD:188910	32/67 (48%)
		SAM	8..73	CDD:197735	31/64 (48%)
		CRIC_ras_sig	84..182	CDD:287501	26/97 (27%)
		PDZ_signaling	229..300	CDD:238492	30/70 (43%)
		DUF1170	347..>475	CDD:284152	34/239 (14%)
		PH_CNK_mammalian-like	555..667	CDD:269962	35/118 (30%)
		PH	569..665	CDD:278594	30/102 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594408
Domainoid	1	1.000	77	1.000	Domainoid score	I8761
eggNOG	1	0.900	-	-		E1_KOG1738
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	266	1.000	Inparanoid score	I3025
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1121556at2759
OrthoFinder	1	1.000	-	-		FOG0001221
OrthoInspector	1	1.000	-	-		otm25178
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12844
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.860