DRSC/TRiP Functional Genomics Resources

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Protein Alignment cnk and fgd6

DIOPT Version :10

Sequence 1:NP_725671.1 Gene:cnk / 36952 FlyBaseID:FBgn0286070 Length:1557 Species:Drosophila melanogaster
Sequence 2:NP_001093450.1 Gene:fgd6 / 556459 ZFINID:ZDB-GENE-041210-200 Length:1315 Species:Danio rerio


Alignment Length:929 Identity:178/929 - (19%)
Similarity:274/929 - (29%) Gaps:310/929 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   629 PPAPPPRPRKQREMTP---PAVPPPPPKPASMQPASSITSISIPVPVPVPAAVDPSEISELHTPS 690
            |.||.|:      :.|   |:.||..|||..:.|:.|.|:.....|...|   .|..:.....|.
Zfish     5 PVAPKPK------LVPLHKPSPPPIAPKPEILLPSPSPTAHKRGKPAVAP---KPCLLKAPQKPV 60

  Fly   691 KSRTLTLKKKHSLMAKRRNTNLKLLGTGDIQGHLYRRKKNHRGVTYWARIYFVMLDTILYGFRSK 755
            ::|....|.:|..::|  |....||                                        
Zfish    61 QARQDHCKNQHPPVSK--NGGPALL---------------------------------------- 83

  Fly   756 QSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYHTAKSFYFAAESLDALNQWVDFLRQASLKVPPS 820
             |::.|..|.               |...||.|.|.         :..|...:..|:|:|.....
Zfish    84 -SSNLSHYII---------------PPCNKVCHLAN---------NKSNDSKEISREATLTTEVG 123

  Fly   821 TGSKGGGDAKDLYS----ENDSSGEECDALVIQNLSTPSPQGNKESMSMSMTLSGGTPPSSAPIK 881
            ...:|....:.|:|    |:.:..|.    |.:.:.|.|.|.:.|:..                 
Zfish   124 VFKEGDSPKEHLFSNDTWEHTARSEH----VQEQVPTDSTQMSTEAQD----------------- 167

  Fly   882 HERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQYRSYRKVPGGSFGIQIGANTPGYHDPAMPPTQ 946
                         .|...|..|..:...|.|..                       |.|...||:
Zfish   168 -------------ETNSPSVEKDQTSTQVLTSD-----------------------HIPRHCPTE 196

  Fly   947 IPPLVGPKLSRSSSRSSVVSGTESAVSLSASILGPPASPAPTPTPTATPTSLQHQSSEE-SPSQS 1010
                  |...|||......:...|..|.|..:..||:.|.|.|.|.....:|..|:..| :||.:
Zfish   197 ------PLQERSSEVKETGNVFSSCTSDSVGVPAPPSKPLPVPHPRRPRRALLRQNVVEIAPSDT 255

  Fly  1011 QSQSPSSKSSLKKAPFNFLHASNPNLVEFDFHTSKTLLPKMSVGNTLDHGHNIQGFVTLKDLMLR 1075
            |:..|:      :.|.|   |.:..|.|         .||    ||..|.|.    .||::....
Zfish   256 QADIPT------ETPEN---AQSDGLQE---------TPK----NTTCHSHT----STLQNACCP 294

  Fly  1076 KQEEEAQEMYNNRVHLGVEKHKHARTESTASQQSAMSSSVTKPLEKLPKIQSVSLPKTPDYEISF 1140
            |::.|                   .|::.:|.:|          :.|.|:.|....:|.|     
Zfish   295 KEDIE-------------------NTDTDSSTKS----------DPLHKVDSFYNAQTED----- 325

  Fly  1141 KPDD-ESIKRTRTKEGQKLRDFGYELICGDEPSTSSISRQEHHHHHHHHQHHLQHVQQQQQLQHQ 1204
            .|.| :|...:....|..|......:..|.:|....                   .:|:...|..
Zfish   326 MPSDLDSTHYSVPTNGATLASMDTAVEDGSQPPAPP-------------------PRQKSLPQMV 371

  Fly  1205 QTQQQHSSKAKHFLRSQQLQLSSFLHKNSSGGSGKSSGSGADQKKSKGKSSGD-RRFPFSKHSTG 1268
            .:..:.|:...:.|          ||..|......|:...|:.......:.|| .|:|.::....
Zfish   372 DSLCKASTSVDNLL----------LHCQSDLQEVTSNDEDAESDDEDDGAYGDFARYPITRSLPK 426

  Fly  1269 SAGSGCGPGHAMTMTLP-LNKKSKSNHALDGAVGNGVTIIGSGSSIKKSQTYNQDLRDKIVGTKY 1332
            .....|| ...:.:|.| ::...||...:.                ||.|      |:.:..:. 
Zfish   427 QIKLSCG-SQVIAITKPYIDGDEKSPKVMP----------------KKPQ------RNSLPASV- 467

  Fly  1333 DAHRKNSAPIPI-FSKLSISGGTPA----KPSKENRFLGSPLLHRTLFGHHHHQQQA-------- 1384
             |.||...|.|: .|...:.|..||    |||........||..|......:.|.||        
Zfish   468 -ALRKQGTPPPLPNSNPPVFGELPAPPQEKPSWRVALPSIPLFSRNQPTRSNSQPQAGVVGSVFV 531

  Fly  1385 ---VTPPSSAD---PDCDQEIFSQITLPTHNQAGYRSYRG-----------PGILTTSTTNLCSS 1432
               ....||||   .|...|...|:......:   ||.|.           |.:|.:..:..|:.
Zfish   532 KQRAKSFSSADLQRVDNGSEASEQLARSDQTR---RSLRKLLELRVCARLLPKLLRSGQSLDCTR 593

  Fly  1433 EGLQPPLPPAPPPPVNTSRQREEEQAEATISECAATPKVSSSGSVDSKAATPDYPNMECPPVFEP 1497
            ...:.....|.|....||...||.|.::. ::|....:     :|......|:|.|:       |
Zfish   594 TDSEYEEHKAVPANQVTSGDDEEAQGDSE-ADCGVEYE-----NVPLYEEIPEYMNL-------P 645

  Fly  1498 EIYSLSDTSLSRIVMRTPS 1516
            .:||..|.......::.||
Zfish   646 WVYSNQDADTDVYEVQEPS 664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cnkNP_725671.1 SAM_CNK1,2,3-suppressor 6..74 CDD:188910
CRIC_ras_sig 82..165 CDD:463138
PDZ_CNK1_2_3-like 203..283 CDD:467230
PH_CNK_insect-like 720..810 CDD:270135 9/89 (10%)
fgd6NP_001093450.1 RhoGEF 773..956 CDD:459876
PH-like 975..1097 CDD:473070
FYVE_FGD6 1113..1173 CDD:277282
PH2_FGD5_FGD6 1221..1309 CDD:270057
Blue background indicates that the domain is not in the aligned region.

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