Protein Alignment cnk and Cnksr1

DIOPT Version :9

• Sequence 1: NP_001286524.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: XP_038965563.1
• Gene: Cnksr1 / 298545
• RGDID: 1311879
• Length: 795
• Species: Rattus norvegicus
• Alignment Length: 1185
• Identity: 225/1185 - (18%)
• Similarity: 347/1185 - (29%)
• Gaps: 504/1185 - (42%)

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            :..|||.:|..|::|||:.::.  |.|...|:.|:.||.:.|..||.|.:..:||||::|..||.
  Rat    68 VETWTPGKVAAWLRGLDDVLQD--YPFEDWELPGKYLLQLCPQNLEALTVWPLGHQELILHGVEQ 130

  Fly    71 LRNFHYHLKNDNLQFMA---LHVATAAKNLHRELARNHAESTKIDTRILHDITRTIATLKPLVGS 132
            ||.....|:.:||:.:|   |....|.::|.:...|:.|| |..|  :|:.....:.....|:..
  Rat   131 LRALGSKLQTENLKSLAQGLLDRTQAFQSLVQGRLRDCAE-TPAD--VLNAAVELVREAHALLSW 192

  Fly   133 LERTPFRKQEMYREYCGNV-LKCGLELATIAHRDRFALQPVPAIRQSAERLENLANFVIQDISDP 196
            |.|..|.....: ..|..: :.|| ||..:...|....:......:...|:..:.:.::....:.
  Rat   193 LNRYLFTHLNDF-SACQEIGVLCG-ELGQVLQEDCLEAEKESNTLRICGRVAGICHNILGCSPEE 255

  Fly   197 MVLQPASLNLVTL---------------KKRESEL---------GFNIESSYNGIHRVTDIKYNS 237
            ::.|.|.|.||.|               ...|::|         |..|.::.|.:|.|:  :...
  Rat   256 LLEQRAVLELVQLDDPSSPGIHVGALPTASTEAKLYLTWPLSLQGLEIHTTSNCLHFVS--RVGV 318

  Fly   238 PAHNSGKIEDGDEIVQINYQTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRL 302
            .|....:|..||||:|||.|.||||.|:.:|..|......|.|.:||.|
  Rat   319 QAATGSQILPGDEIIQINEQVVVGWPHKNMLRELLREPARVSLVLKKIP---------------- 367

  Fly   303 PSKKRNMAARWAAQMPSPRAAFLTLDTEQLATGGTGSAVPD-PSKSLSSEKREVLTKANPVSSAS 366
                                                  ||: |||
  Rat   368 --------------------------------------VPETPSK-------------------- 374

  Fly   367 DSDSSCSDIPTPTD-PKLAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGI 430
                      ||.| |:..::.:.|..|.||                       ||
  Rat   375 ----------TPPDSPQRLSQSLPLNPPSPR-----------------------VP--------- 397

  Fly   431 GSPTNCDPGSPSIRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQRE 495
                                                                           ||
  Rat   398 ---------------------------------------------------------------RE 399

  Fly   496 FLVDRYKPGVSKVVRFDAKEDYVMKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCKTEN 560
            .|.|
  Rat   400 GLFD------------------------------------------------------------- 403

  Fly   561 AEELLEAINLATKGQDLPLAEAINMPLLQQGRRGRLDKSHSTPAY-DNSGEESDTPPAIEPRKEF 624
                   .||:|.|...|                       :||: |::..::...|
  Rat   404 -------FNLSTDGNPSP-----------------------SPAWTDSTSLDAQPTP-------- 430

  Fly   625 LLVTPPAPP-PRPRKQREMTPPAVPPPPPKPASMQPASSITSISIPVPVPVPAAVDPSEISELHT 688
               |||.|| ..|.:..|                             |:.....:|
  Rat   431 ---TPPGPPGTLPEETAE-----------------------------PLEASGHLD--------- 454

  Fly   689 PSKSRTLTLKKKHSLMAK--RRNTNLKLLGTGDIQGHLYRRK--KNHRGVTYWARIYFVMLDTIL 749
              ||.|:..|....:..:  ||..:.:.||..|..|.|..||  ....|.. |.|.:||:....|
  Rat   455 --KSPTVGRKNSKGIATRLSRRRVSCRELGLPDCDGWLLLRKVPGGFMGAR-WRRCWFVLKGHTL 516

  Fly   750 YGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYHTA-KSFYFAAESLDALNQWVDFLRQA 813
            |.:|..|...|..:|.:..:::....: ..|.:.|::.|.. |.|.||||:|..|:.||..|...
  Rat   517 YWYRQPQDEKAEGLINISNYSLECGHD-QKKKYVFQLTHDVYKPFIFAAETLSDLSMWVRHLVTC 580

  Fly   814 SLKVPPSTGSKGGGDAKDLYSENDSSGEECDALVIQNLSTPSPQGNKESMSMSMTLSGGTPPSSA 878
            ..|. .:.|.......:|.|||.::  |:.|.......::|.|          ......|.||::
  Rat   581 ISKY-QTLGRAPSAREEDCYSETEA--EDPDEEAGSRSASPGP----------AQAWNDTSPSAS 632

  Fly   879 PIKHERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQYRSYRKVPGGSFGIQIGANTPGYHDPAMP 943
            |::..|          .:|.||.  .|||           |.:.|...|::.|
  Rat   633 PLQSPR----------TSFGSSL--DSSD-----------RALEGMVQGLRQG------------ 662

  Fly   944 PTQIPPLVGPKLSRSSSRSSVVSGTESAVSLSASILGPPASPAPTPTPTATPTSLQHQSSEESPS 1008
                                           ..|:||             .|..|.|:....|
  Rat   663 -------------------------------GVSLLG-------------QPQPLTHEQWRSS-- 681

  Fly  1009 QSQSQSPSSKSSLKKAPFNFLHAS-NPNLVEFDFHTSK------TLLPKMSVGNTLDHGHNIQGF 1066
                               |:..: :|:|.|   |..:      ||..|:.....|:   .:.|.
  Rat   682 -------------------FMRRNRDPHLNE---HVHRVRALQSTLKAKLQELQVLE---EVLGD 721

  Fly  1067 VTLKDLMLRKQEEEAQEMYNN--RVHLGVEKHKHARTESTASQQSAMSSSVTKPLEKLPKIQSVS 1129
            ..|.....|:.:|:..|:|:.  |...|:    .|:|.|......:...| .:||...|:..|..
  Rat   722 PELTGAKFRQWKEQNHELYSEGLRTWGGM----WAQTSSPDPNTDSRGQS-PQPLPSDPEEPSQL 781

  Fly  1130 LPKTPDYEISFKPDD 1144
            .|.||  |.|.:|.|
  Rat   782 FPSTP--ENSLQPPD 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	27/67 (40%)
		SAM	7..74	CDD:197735	27/66 (41%)
		CRIC_ras_sig	82..165	CDD:287501	21/86 (24%)
		PDZ_signaling	206..283	CDD:238492	29/100 (29%)
		PH	720..814	CDD:278594	29/96 (30%)
		PH_CNK_insect-like	720..810	CDD:270135	28/92 (30%)
Cnksr1	XP_038965563.1	SAM_superfamily	68..134	CDD:417767	27/67 (40%)
		CRIC_ras_sig	142..225	CDD:402249	21/87 (24%)
		PDZ_signaling	300..364	CDD:238492	24/65 (37%)
		PH_CNK_mammalian-like	472..585	CDD:269962	35/115 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352478
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1738
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I2957
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1121556at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46231
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12844
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.860