DRSC/TRiP Functional Genomics Resources

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Protein Alignment cnk and Cnksr2

DIOPT Version :9

Sequence 1:NP_001286524.1 Gene:cnk / 36952 FlyBaseID:FBgn0286070 Length:1557 Species:Drosophila melanogaster
Sequence 2:NP_808419.1 Gene:Cnksr2 / 245684 MGIID:2661175 Length:1032 Species:Mus musculus


Alignment Length:1233 Identity:289/1233 - (23%)
Similarity:470/1233 - (38%) Gaps:340/1233 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            :::|:|.||.||:||||:.::.|:..|.:::|.|..||.|...|||:||:.||||||::||||:.
Mouse     8 VSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDL 72

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELA----RNHAE---STKIDTRILHDITRTIATLKP 128
            |...:|.|:.:||:.::..:..:||||...:.    ..|.:   |.|:....|..:...|...|.
Mouse    73 LCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKS 137

  Fly   129 LVGSLERTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLANFVIQDI 193
            |:..|:|:||.....|.....||::..|||.||..:|....:....|....:.|..:.:.:|...
Mouse   138 LLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLS 202

  Fly   194 SDPMVLQPASLNLVTLK--KRESELGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINY 256
            |||:|.|.|.|.::.|.  |....||..|:|:|:|:|.:|....||||....||..|||::|:|:
Mouse   203 SDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNH 267

  Fly   257 QTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARW---AAQMP 318
            |||||||.:.::..|||....|:||:||||:....         ..|:..:||  ||   |.|..
Mouse   268 QTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLT---------SAPALLKNM--RWKPLALQPL 321

  Fly   319 SPRAAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDSDSSC-SDI---PTPT 379
            .||:                     |:.|       |.|.::.:|:.:..|||. .|:   |.|.
Mouse   322 IPRS---------------------PTSS-------VATPSSTISTPTKRDSSALQDLYIPPPPA 358

  Fly   380 DPKLAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGIGSPTNCDPGSPS-- 442
            :|         |.|:.    ::.|..|         .||       |...:|.|.:....||:  
Mouse   359 EP---------YIPRD----EKGNLPC---------EDL-------RGHMVGKPVHKGSESPNSF 394

  Fly   443 -----------IRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQREF 496
                       :.:.::.:.|..|           .|.:|:...|.......||:.::...:..:
Mouse   395 LDQEYRKRFNIVEEDTVLYCYEYE-----------KGRSSSQGRRESTPTYGKLRPISMPVEYNW 448

  Fly   497 LVDRYKPGVSKVVRFDAKEDYV---MKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCKT 558
            :.|...|  :|:.|...:|:.:   |.|||..                     ::.....||.|.
Mouse   449 VGDYEDP--NKMKRDSRRENSLLRYMSNEKIA---------------------QEEYMFQRNSKK 490

  Fly   559 ENAEELLEAINLATKGQDLPLAEAINMPLLQQGRRGRLDKSHSTPAYDNSGEESDTPPAIEPRKE 623
            :..:                          :..::|  |||:|...|                  
Mouse   491 DTGK--------------------------KSKKKG--DKSNSPAHY------------------ 509

  Fly   624 FLLVTPPAPPPRPRKQREMTPPAVPPPPPKPASMQPASSITSIS---IPVPVPVPAAVDPSEISE 685
                                            |:.|:..:.::.   :..|||........:.|.
Mouse   510 --------------------------------SLLPSLQMDALRQDIMGTPVPETTLYHTFQQSS 542

  Fly   686 LHTPSKSRTLTLKKKHSLMAK-RRNTNLKLLGTGDIQGHLYRRKKNHRGVTY----WARIYFVML 745
            |...||.     |.|.::..| :|..:.|.||.||.:|.|:::|.   ..:|    |.:.:||:.
Mouse   543 LQHKSKK-----KNKGAISGKSKRRISCKDLGRGDCEGWLWKKKD---AKSYFSQKWKKYWFVLK 599

  Fly   746 DTILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYH-TAKSFYFAAESLDALNQWVDF 809
            |..||.:.:::...|...|.||.|.:..|.|...| :|||..| ..||||||||.||.:|:|::.
Mouse   600 DASLYWYINEEDEKAEGFISLPEFKIDRASECRKK-YAFKACHPKIKSFYFAAEHLDDMNRWLNR 663

  Fly   810 LRQASLKVPPSTGSKGGGDAKDLYSENDSSGEECDALVIQNLSTPSPQGNKESMSMSMTLS---- 870
            :...:.........|   ..:|.:||:|.  ||.|........:|.|..:......||:.:    
Mouse   664 INMLTAGYAERERIK---QEQDYWSESDK--EEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYV 723

  Fly   871 -------GGTPPSSAPIKHERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQYRSYR---KVPGGS 925
                   ..|..|.:...||     .||:  ....|||..|   |.....|.||::   :.|..|
Mouse   724 EAKHSRLSSTETSQSQSSHE-----EFRQ--EVTGSSAVSP---IRKTASQRRSWQDLIETPLTS 778

  Fly   926 FGIQI--------------GANTPGYHDPAMPPTQ---IPPLVGPKLSRSSSRSSVVSGTESA-- 971
            .|:..              .|.:|.:...:..|||   :....||.....|.|..|::|....  
Mouse   779 SGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPR 843

  Fly   972 -------VSLSASILGPPASPAPTPTPTATPTSLQHQSSEESPS--------------------- 1008
                   ...:...|..|.| |..|.....|..::.:..||...                     
Mouse   844 SFTLPRDSGFNHCCLNTPVS-ACDPQDDIQPPEVEEEEEEEEEEAAGENVGEKNENREEKLGDSL 907

  Fly  1009 -------QSQSQSP------SSKSSLKKAPFNFLHASNPNLVEFDFHTSKTLLPKMSVGNTLDHG 1060
                   :..|.||      |:|...|   .:|:...|..::....|..:.|...:...      
Mouse   908 QDLYRALEEASLSPLGEHRISTKMEYK---LSFIKRCNDPVMNEKLHRLRILKSTLKAR------ 963

  Fly  1061 HNIQGFVTLKDLML------RKQEEEAQEMYNNRVHLGVEKHKHARTE-STASQQSAMSSSVT 1116
               :|.|.:.|.:|      .|:.::.::||.: :.|.:.:...:... |.:|:...::||:|
Mouse   964 ---EGEVAIIDKVLDNPDLTSKEFQQWKQMYLD-LFLDICQSTTSNDPLSISSEVDVLTSSLT 1022

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cnkNP_001286524.1 SAM_CNK1,2,3-suppressor 6..74 CDD:188910 33/67 (49%)
SAM 7..74 CDD:197735 33/66 (50%)
CRIC_ras_sig 82..165 CDD:287501 25/89 (28%)
PDZ_signaling 206..283 CDD:238492 34/78 (44%)
PH 720..814 CDD:278594 34/98 (35%)
PH_CNK_insect-like 720..810 CDD:270135 34/94 (36%)
Cnksr2NP_808419.1 SAM_CNK1,2,3-suppressor 8..76 CDD:188910 33/67 (49%)
SAM 8..73 CDD:197735 32/64 (50%)
CRIC_ras_sig 84..176 CDD:287501 26/91 (29%)
Peptidase_C98 139..>218 CDD:292138 23/78 (29%)
PDZ_signaling 222..294 CDD:238492 33/71 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 324..349 9/52 (17%)
DUF1170 341..561 CDD:284152 55/365 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 480..509 8/56 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 538..558 6/24 (25%)
PH_CNK_mammalian-like 559..672 CDD:269962 40/116 (34%)
PH 573..669 CDD:278594 34/99 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 682..766 23/95 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 864..900 5/35 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848866
Domainoid 1 1.000 76 1.000 Domainoid score I8945
eggNOG 1 0.900 - - E1_KOG1738
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 267 1.000 Inparanoid score I3022
Isobase 1 0.950 - 0 Normalized mean entropy S6579
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1121556at2759
OrthoFinder 1 1.000 - - FOG0001221
OrthoInspector 1 1.000 - - otm44139
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12844
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3250
SonicParanoid 1 1.000 - - X1572
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.840

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