Protein Alignment cnk and CNKSR2

DIOPT Version :10

• Sequence 1: NP_725671.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: NP_055742.2
• Gene: CNKSR2 / 22866
• HGNCID: 19701
• Length: 1034
• Species: Homo sapiens
• Alignment Length: 1099
• Identity: 266/1099 - (24%)
• Similarity: 425/1099 - (38%)
• Gaps: 285/1099 - (25%)

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            :::|:|.||.||:||||:.::.|:..|.:::|.|..||.|...|||:||:.||||||::||||:.
Human     8 VSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDL 72

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELA----RNHAE---STKIDTRILHDITRTIATLKP 128
            |...:|.|:.:||:.::..:..:||||...:.    ..|.:   |.|:....|..:...|...|.
Human    73 LCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKS 137

  Fly   129 LVGSLERTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLANFVIQDI 193
            |:..|:|:||.....|.....||::..|||.||..:|....:....|....:.|..:.:.:|...
Human   138 LLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLS 202

  Fly   194 SDPMVLQPASLNLVTLK--KRESELGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINY 256
            |||:|.|.|.|.::.|.  |....||..|:|:|:|:|.:|....||||....||..|||::|:|:
Human   203 SDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNH 267

  Fly   257 QTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARW---AAQMP 318
            |||||||.:.::..|||....|:||:||||:....         ..|:..:||  ||   |.|..
Human   268 QTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLT---------SAPALLKNM--RWKPLALQPL 321

  Fly   319 SPRAAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDSDSSC-SDI---PTPT 379
            .||:                     |:.|       |.|.::.:|:.:..|||. .|:   |.|.
Human   322 IPRS---------------------PTSS-------VATPSSTISTPTKRDSSALQDLYIPPPPA 358

  Fly   380 DPKLAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGIGSPTNCDPGSPS-- 442
            :|         |.|:.    ::.|..|         .||       |...:|.|.:....||:
Human   359 EP---------YIPRD----EKGNLPC---------EDL-------RGHMVGKPVHKGSESPNSF 394

  Fly   443 -----------IRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQREF 496
                       :.:.::.:.|..|           .|.:|:...|.......||:.::...:..:
Human   395 LDQEYRKRFNIVEEDTVLYCYEYE-----------KGRSSSQGRRESTPTYGKLRPISMPVEYNW 448

  Fly   497 LVDRYKPGVSKVVRFDAKEDYV---MKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCKT 558
            :.|...|  :|:.|...:|:.:   |.|||..                     ::.....||.|.
Human   449 VGDYEDP--NKMKRDSRRENSLLRYMSNEKIA---------------------QEEYMFQRNSKK 490

  Fly   559 ENAEELLEAINLATKGQDLPLAEAINMPLLQQGRRGRLDKSHSTPAYDNSGEESDTPPAIEPRKE 623
            :..:                          :..::|  |||:|...|
Human   491 DTGK--------------------------KSKKKG--DKSNSPTHY------------------ 509

  Fly   624 FLLVTPPAPPPRPRKQREMTPPAVPPPPPKPASMQPASSITSIS---IPVPVPVPAAVDPSEISE 685
                                            |:.|:..:.::.   :..|||........:.|.
Human   510 --------------------------------SLLPSLQMDALRQDIMGTPVPETTLYHTFQQSS 542

  Fly   686 LHTPSKSRTLTLKKKHSLMAK-RRNTNLKLLGTGDIQGHLYRRKKNHRGVTY----WARIYFVML 745
            |...||.     |.|..:..| :|..:.|.||.||.:|.|:::|.   ..:|    |.:.:||:.
Human   543 LQHKSKK-----KNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKD---AKSYFSQKWKKYWFVLK 599

  Fly   746 DTILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYH-TAKSFYFAAESLDALNQWVDF 809
            |..||.:.:::...|...|.||.|.:..|.|...| :|||..| ..||||||||.||.:|:|::.
Human   600 DASLYWYINEEDEKAEGFISLPEFKIDRASECRKK-YAFKACHPKIKSFYFAAEHLDDMNRWLNR 663

  Fly   810 LRQASLKVPPSTGSKGGGDAKDLYSENDSSGEECDALVIQNLSTPSPQGNKESMSMSMTLS---- 870
            :...:.........|   ..:|.:||:|.  ||.|........:|.|..:......||:.:
Human   664 INMLTAGYAERERIK---QEQDYWSESDK--EEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYV 723

  Fly   871 -------GGTPPSSAPIKHERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQYRSYR---KVPGGS 925
                   ..|..|.:...||     .||:  ....|||..|   |.....|.||::   :.|..|
Human   724 EAKHSRLSSTETSQSQSSHE-----EFRQ--EVTGSSAVSP---IRKTASQRRSWQDLIETPLTS 778

  Fly   926 FGIQI--------------GANTPGYHDPAMPPTQ---IPPLVGPKLSRSSSRSSVVSGTESA-- 971
            .|:..              .|.:|.:...:..|||   :....||.....|.|..|::|....
Human   779 SGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPR 843

  Fly   972 -------VSLSASILGPPASPAPTPTPTATPTSLQHQSSEESPSQSQSQSPSSKSSLKK 1023
                   ...:...|..|.|..........|...:.:..||...::..::...||..::
Human   844 SFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESRE 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_725671.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	33/67 (49%)
		CRIC_ras_sig	82..165	CDD:463138	25/89 (28%)
		PDZ_CNK1_2_3-like	203..283	CDD:467230	35/81 (43%)
		PH_CNK_insect-like	720..810	CDD:270135	34/94 (36%)
CNKSR2	NP_055742.2	SAM_CNK1,2,3-suppressor	8..76	CDD:188910	33/67 (49%)
		CRIC_ras_sig	84..176	CDD:463138	26/91 (29%)
		PDZ_CNK1_2_3-like	214..294	CDD:467230	34/79 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	324..349		9/52 (17%)
		CNK2_3_dom	339..>487	CDD:461979	34/210 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	480..510		9/107 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	539..559		6/24 (25%)
		PH_CNK_mammalian-like	559..672	CDD:269962	40/116 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..766		23/95 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	864..905		5/39 (13%)