DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cnk and Cnksr1

DIOPT Version :9

Sequence 1:	NP_001286524.1	Gene:	cnk / 36952	FlyBaseID:	FBgn0286070	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	NP_001074516.1	Gene:	Cnksr1 / 194231	MGIID:	2670958	Length:	700	Species:	Mus musculus

Alignment Length:	1196	Identity:	224/1196 - (18%)
Similarity:	344/1196 - (28%)	Gaps:	557/1196 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            :..|||.:|..|::|||::::.  |.|...::.|:.||.:.|..||.|.:..:||||::|:.||.
Mouse     4 VEAWTPGKVAAWLRGLDDALQD--YPFEDWQLPGKYLLQLCPQSLEALTVWPLGHQELILDGVEQ 66

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELARNHAESTKIDTRILHDITRTIATLKPLVGSLER 135
            ||....:|:.:|||.:|..:          |.|..|..:.:...:               |:...
Mouse    67 LRALGSNLQTENLQSLAQGL----------LERTQAFQSLVQGSL---------------GNCAE 106

  Fly   136 TPFRKQEMYREYCGNVLKCGLELATIAH--------------RDRFALQPVPAI----------- 175
            ||           .:|||..:||...||              .|..|.|.:..:
Mouse   107 TP-----------ADVLKAAVELVREAHALLSWLNGYLFSHLNDFSACQEIGVLCGELGQVLQED 160

  Fly   176 RQSAERLENLANF----------VIQDISDPMVLQPASLNLVTLKKRESELGFNIESSYNGIHRV 230
            ...||:..|:...          ::....:.::.|.|.|..|.:   :...|..|.::.|.:|.|
Mouse   161 CPEAEKERNILRICSHVAGICHNILSCSPEELLEQKAVLESVQV---DDPSGLEIHTTSNCLHFV 222

  Fly   231 TDIKYNSPAHNSGKIEDGDEIVQINYQTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQI 295
            :  :....|..|.:|..||||||:|.|.||||.|:.:|..|......|.|.:||.|
Mouse   223 S--RVGVQAATSSQILPGDEIVQVNEQVVVGWSHKNMLRELLREPAKVSLVLKKIP--------- 276

  Fly   296 YMQPYRLPSKKRNMAARWAAQMPSPRAAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKAN 360
                                                         ||:                .
Mouse   277 ---------------------------------------------VPE----------------T 280

  Fly   361 PVSSASDSDSSCSDIPTPTDPKLAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHE 425
            |..::.||            |.|.::.:.|..|.||                       |||
Mouse   281 PSQTSLDS------------PHLLSQSLPLNPPSPR-----------------------VPS--- 307

  Fly   426 RKPGIGSPTNCDPGSPSIRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTE 490

Mouse   308 ----------------------------------------------------------------- 307

  Fly   491 DSQREFLVDRYKPGVSKVVRFDAKEDYVMKNEKFICNVENTILETFEPIPFADEGDEDALETLRN 555
                                                                 ||
Mouse   308 -----------------------------------------------------EG---------- 309

  Fly   556 CKTENAEELLEAINLATKGQDLPLAEAINMPLLQQGRRGRLDKSHSTPAY-DNSGEESDTPPAIE 619
                                           ||..|..|      .:||: |::..::.:||
Mouse   310 -------------------------------LLADGTPG------PSPAWTDSTSFDAQSPP--- 334

  Fly   620 PRKEFLLVTPPAPPPRPRKQREMTPPAVPPPPPKPASMQPASSITSISIPVPVPVPAAVDPSEIS 684
                    |||.||                                           .|.|.|.:
Mouse   335 --------TPPGPP-------------------------------------------GVLPEETA 348

  Fly   685 E-LHT---PSKSRTLTLKKKHSLMAK--RRNTNLKLLGTGDIQGHLYRRK--KNHRGVTYWARIY 741
            | |.:   |.||..|..||...:..:  ||..:.:.||..|..|.|..||  ....| ..|.|.:
Mouse   349 EPLESSGHPDKSPILGRKKSKGIATRLSRRRVSCRELGLPDCDGWLLLRKVPGGFMG-PRWRRCW 412

  Fly   742 FVMLDTILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYHTA-KSFYFAAESLDALNQ 805
            ||:....||.:|..|...|..:|.|..:::....: ..|.:.|::.|.. |.|.||||:|..|::
Mouse   413 FVLKGHTLYWYRQPQDEKAEGLINLSNYSLESGHD-QKKKYVFQLTHDVYKPFIFAAETLSDLSK 476

  Fly   806 WVDFL------RQASLKVPPSTGSKGGGDAKDLYSENDSSGEECDALVIQNLSTPSPQGNKESMS 864
            ||..|      .||..:.|.|...      :|.|||.::  |:.|.......::|.|     :.:
Mouse   477 WVRHLITCISKYQAQGRAPSSARE------EDCYSETEA--EDPDEEAGSRSASPGP-----AQA 528

  Fly   865 MSMTLSGGTPPSSAPIKHERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQYRSYRKVPGGSFGIQ 929
            .|     .|.|.::|::..|          .:|.||   |.|          |.|.:.|...|::
Mouse   529 WS-----DTSPVASPLQSPR----------TSFNSS---PDS----------SDRALEGMVQGLR 565

  Fly   930 IGANTPGYHDPAMPPTQIPPLVGPKLSRSSSRSSVVSGTESAVSLSASILGPPASPAPTPTPTAT 994
            .|                                           ..|:||             .
Mouse   566 QG-------------------------------------------GVSLLG-------------Q 574

  Fly   995 PTSLQHQSSEESPSQSQSQSPSSKSSLKKAPFNFLHAS-NPNLVEFDFH---TSKTLLPKMSVGN 1055
            |..|.|:....|                     |:..: :|:|.|....   ...||..|:....
Mouse   575 PQPLTHEQWRSS---------------------FMRRNRDPHLNERAHRIRALQSTLKAKLQELQ 618

  Fly  1056 TLDHGHNIQGFVTLKDLMLRKQEEEAQEMYNN--RVHLGVEKHKHARTESTASQQSAMSSSVTKP 1118
            .|:   .:.|...|.....|:.:|:.||:|:.  |...|.    .|:|.|:.....:.:.| .:|
Mouse   619 ALE---EVLGDPELTSAKFRQWKEQNQELYSEGLRTWGGT----WAQTSSSDPNSDSRAHS-PQP 675

  Fly  1119 LEKLPKIQSVSLPKTPDYEISFKPDD 1144
            |...|:..|...|.||  |.|.:|.|
Mouse   676 LPFDPEEPSQLFPLTP--ENSRQPPD 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	26/67 (39%)
		SAM	7..74	CDD:197735	26/66 (39%)
		CRIC_ras_sig	82..165	CDD:287501	17/96 (18%)
		PDZ_signaling	206..283	CDD:238492	26/76 (34%)
		PH	720..814	CDD:278594	31/102 (30%)
		PH_CNK_insect-like	720..810	CDD:270135	29/92 (32%)
Cnksr1	NP_001074516.1	SAM_superfamily	4..70	CDD:301707	26/67 (39%)
		SAM	4..69	CDD:197735	25/66 (38%)
		CRIC_ras_sig	78..162	CDD:287501	20/119 (17%)
		PDZ_signaling	205..273	CDD:238492	25/69 (36%)
		PH_CNK_mammalian-like	376..489	CDD:269962	35/114 (31%)
		PH	390..486	CDD:278594	30/97 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848871
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1738
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3022
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12844
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.850