DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cnk and cnk-1

DIOPT Version :9

Sequence 1:	NP_001286524.1	Gene:	cnk / 36952	FlyBaseID:	FBgn0286070	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	NP_499274.3	Gene:	cnk-1 / 187518	WormBaseID:	WBGene00000564	Length:	801	Species:	Caenorhabditis elegans

Alignment Length:	935	Identity:	204/935 - (21%)
Similarity:	356/935 - (38%)	Gaps:	259/935 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            :.:|...::..||:||.:.|..||.........|:.|..:....|:.:|:..:|.::.:.:||..
Worm    53 VEQWKGKEIARWIEGLGDQMNPYLGMIRDNIKSGKQLEALDDDSLKKIGISALGARKTIFQAVSL 117

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELA-----RNHAESTKIDTRILHDITRTIATL---- 126
            |..|.:..:::|||.:|..|.|:...:.|.:.     |..|........||:.::..:..|
Worm   118 LLYFCHESEHENLQRLAQQVKTSCLYVERTMTSAMRMREKAIRRSEIVNILNSVSNAVLQLAEHT 182

  Fly   127 KPLVGSLERTPFRKQEMY-------REYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLEN 184
            |..|..|:||||.::..:       ..:..|:|:            ...:|| .|:.::..::..
Worm   183 KRFVFWLDRTPFDEEPEFINVRNSVSSFMWNLLR------------NVNVQP-KALFETGSQIVR 234

  Fly   185 LANFV------IQDISDPMVLQPASLNLVTLKKRESEL--GFNIESSYNGIHRVTDIKYNSPAHN 241
            ::..:      |.|..||::|....:....|::|...:  |.||:|||.|:|.:::||..|||..
Worm   235 MSKELAYECQKIVDCDDPLILYACFIESALLRRRSDNINWGLNIQSSYRGVHVISEIKEGSPADA 299

  Fly   242 SGKIEDGDEIVQINYQTVVGWQHRTVLEHLREALPDVV---LTVKKRPKHTKMFGQIYMQPYRLP 303
            ..||:.||||:.||.:|||||...:|::.: .|| ||:   |.||:||:          :| :||
Worm   300 CTKIDAGDEILMINGRTVVGWDLTSVVQQV-GAL-DVLELSLIVKRRPR----------EP-QLP 351

  Fly   304 SKKRNMAARWAAQMPSPRAAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDS 368
             |:..:|||  |..||.:.|                      |:.|::..:...::.|:.    .
Worm   352 -KQSKLAAR--ALAPSSQTA----------------------KTYSTDDYDPFGQSEPLK----R 387

  Fly   369 DSSC---SDIPTPTDPKLAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGI 430
            ..||   |:|....:     |:||:    .|.|::|.:....|.....||.|       ||
Worm   388 HRSCHVISEIIKENE-----RKIRI----SRRLIRRSSIASACPRKERKNID-------ER---- 432

  Fly   431 GSPTNCDPGSPSIRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQRE 495
                                              .:.||...|..   .||..:    ..|.:.|
Worm   433 ----------------------------------ALDGDDEDDWD---VHEFIR----NVDGEEE 456

  Fly   496 FLVDRYKPGVSKVVRF--DAKEDYVMK--NEKFICNVENTILE---TFE---PIPFAD--EGDED 548
            .||    |.::|..|.  ...:.||..  :.|.:.::|:.::.   ||.   |..||.  |.|::
Worm   457 ALV----PRIAKRTRTMRHQPDGYVRSFIDNKLVTDIEDDVVNDQLTFNVKCPNEFAQIKEVDKE 517

  Fly   549 ALETLRNCKTENAEELLEAINLATKGQDLPLAEAINMPLLQQGRRGRLDKSHSTPAYDNSGEESD 613
            .|:.|...:...::|..:|          |..|                  .:.|::...|:.:.
Worm   518 ELKVLNLPEARVSDEDWKA----------PYQE------------------FAAPSFRAVGDSNI 554

  Fly   614 TPPAIEPRKEFLLVTPPAPPPRPRKQREMTPPA--VPPPPPKPASMQPASSITSISIPVPV---- 672
            :        .|.|.:|...|...|....:...|  |.|.|       ..||:.|:|.|.|.
Worm   555 S--------GFSLDSPRLLPVSSRMTSSVEESAFGVLPSP-------STSSMNSVSSPAPFGKFQ 604

  Fly   673 ---------PVPAAVDPSEISELHTPSKSRTLTLKKKHSLMAKRRNTNLKLLGTGDIQGHLYRRK 728
                     |.|..:..|.||..:.       .::|......:||.|..:|
Worm   605 MSTSQTEWSPNPDDLPGSPISAAYA-------GMEKLFEGWVRRRKTRAEL-------------- 648

  Fly   729 KNHRGVT-YWARIYFVMLDTILYGFRSKQSTSASLVIFLPGFTVSLAKEVH-SKPHAFKVYHTAK 791
             |...:| .|.:|:..:....|..:.::.:....:||.|...|:|.:.::. ||.:.|::.....
Worm   649 -NANELTNKWPKIWMCLRGHYLLLYTNQNTKRPEMVINLIKATISDSTDLKTSKKNIFRITAAPL 712

  Fly   792 SFYFAA-ESLDALNQWVDFLRQASLKVPPSTGSKG-------GGDAKDLYSENDSSGEECDALVI 848
            .::|:. .:||..| |...::.|. ::..:.|::.       .....||..:|...|::..:
Worm   713 DYHFSCFTALDWRN-WTQKMKMAK-EIFANAGTQPRIMSQSVSSYNNDLSDQNFFLGQQTGS--- 772

  Fly   849 QNLST-PSPQGNKESMSMSMTLSGG 872
             .||| |....|..:.|.|..|.||
Worm   773 -GLSTLPRVTTNGMTTSKSGGLGGG 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	16/67 (24%)
		SAM	7..74	CDD:197735	16/66 (24%)
		CRIC_ras_sig	82..165	CDD:287501	21/98 (21%)
		PDZ_signaling	206..283	CDD:238492	34/81 (42%)
		PH	720..814	CDD:278594	18/96 (19%)
		PH_CNK_insect-like	720..810	CDD:270135	18/92 (20%)
cnk-1	NP_499274.3	SAM	53..119	CDD:197735	15/65 (23%)
		SAM_superfamily	53..118	CDD:301707	15/64 (23%)
		CRIC_ras_sig	129..219	CDD:287501	21/101 (21%)
		PDZ_signaling	267..337	CDD:238492	32/71 (45%)
		PH	636..736	CDD:278594	23/116 (20%)
		PH-like	636..731	CDD:302622	22/110 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166656
Domainoid	1	1.000	60	1.000	Domainoid score	I7052
eggNOG	1	0.900	-	-		E1_KOG1738
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6579
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001221
OrthoInspector	1	1.000	-	-		oto18117
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12844
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3250
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780