DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cnk and SAMD3

DIOPT Version :9

Sequence 1:	NP_001286524.1	Gene:	cnk / 36952	FlyBaseID:	FBgn0286070	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	NP_001264114.1	Gene:	SAMD3 / 154075	HGNCID:	21574	Length:	544	Species:	Homo sapiens

Alignment Length:	293	Identity:	55/293 - (18%)
Similarity:	111/293 - (37%)	Gaps:	87/293 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVENLRN 73
            |:.:||..|:  :::::...::.|.::|:.|.|||.:....::.| :.:||||.::::.::..:.
Human    28 WSVEQVCSWL--VEKNLGELVHRFQEEEVSGAALLALNDRMVQQL-VKKIGHQAVLMDLIKKYKQ 89

  Fly    74 FHYHLKN-DNLQFMALHVATAAKNLHRE----LARNHAESTK------------IDTRIL----- 116
            ....||: :|.:..||.:.|.|...:|:    ....|.|...            ||.|:|
Human    90 NTQGLKSPENPKKAALVMQTEAARDYRDEESSSPARHGEQMPSFYPAENLDNGLIDQRVLKQRRN 154

  Fly   117 -----------------------HDITRTIATLK----------------PLVGSLERTPFRKQE 142
                                   :|:...:|..|                .:...||.:.:...:
Human   155 VKQILARSKALQWTKSYVLPEFPYDVKCMLAEQKCPDHSMRIRIIEFLQADMTKYLEGSLYPSTQ 219

  Fly   143 MYREYCGNVLK---------CGLELATIAHRDRFALQPVPAIRQSAERLENLANF------VIQD 192
            .|.:....:|:         ||..|...|.:|||.....| |....:.:.|...|      ..:.
Human   220 QYNDVVNALLQAHPFLDEDGCGFFLWKRALKDRFKYVRRP-IEDDEQVIRNKCKFGHRRGQTRKS 283

  Fly   193 ISDPMVLQPASLNLVTLKKR----ESELGFNIE 221
            ::|   ::...:.||.:|:.    :|||..:|:
Human   284 LAD---IRFDEIKLVQIKEEAVCFDSELDEHIK 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	15/64 (23%)
		SAM	7..74	CDD:197735	15/64 (23%)
		CRIC_ras_sig	82..165	CDD:287501	23/151 (15%)
		PDZ_signaling	206..283	CDD:238492	7/20 (35%)
		PH	720..814	CDD:278594
		PH_CNK_insect-like	720..810	CDD:270135
SAMD3	NP_001264114.1	SAM_Samd3	25..90	CDD:188925	15/64 (23%)
SAMD3	NP_001264114.1	SAM	25..89	CDD:197735	15/63 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158473
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930