DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cnk and CNKSR3

DIOPT Version :9

Sequence 1:	NP_001286524.1	Gene:	cnk / 36952	FlyBaseID:	FBgn0286070	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	NP_001355045.1	Gene:	CNKSR3 / 154043	HGNCID:	23034	Length:	561	Species:	Homo sapiens

Alignment Length:	600	Identity:	162/600 - (27%)
Similarity:	251/600 - (41%)	Gaps:	136/600 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AEWTPDQVTDWI------KGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVL 65
            |||.......::      :|||:.::.|:::|.:::|.|..||.|...:||.||:.||||||:||
Human     5 AEWPVRSYLSYLLRALPFQGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVL 69

  Fly    66 EAVENLRNFHYHLKNDNLQFMALHVATAAKNLHRELARNHAE-------STKIDTRILHDITRTI 123
            |||:.|...:|.|:.||::.:.|.:..::.||...::.....       |.|.....|..:...|
Human    70 EAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEFLTSVVELI 134

  Fly   124 ATLKPLVGSLERTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLANF 188
            ...|.|:..|:|.||.....:......:::..|:|.|...:|.|..:....:....:.|..:.:.
Human   135 GAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDK 199

  Fly   189 VIQDISDPMVLQPASL---NLVTLKKRESELGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDE 250
            .|:..:||::.|.|.|   :|..:|..|. ||..|:|:|:|:|.:|....||||..|.||..|||
Human   200 TIRSTTDPVMSQCACLEEVHLPNIKPGEG-LGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDE 263

  Fly   251 IVQINYQTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARW-- 313
            ::|:|.|||||||.:.:::.|||....|||.:||||..:..|         .|:..:|:  ||
Human   264 VIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNF---------TPAPLKNL--RWKP 317

  Fly   314 --------AAQMPSPRAAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVL------TKANPVSS 364
                    .|...||.:   |:||                 ||..||..:|      ..|.|.|.
Human   318 PLVQTSPPPATTQSPES---TMDT-----------------SLKKEKSAILDLYIPPPPAVPYSP 362

  Fly   365 ASDS-------DSSCSD-IPTPTDPKLAAREIRLYYPKPRALL-----QRRNTICGCEYLSLKNS 416
            ..::       .|.|.. :|.|...:           .|.:.|     :||.||...:.|
Human   363 RDENGSFVYGGSSKCKQPLPGPKGSE-----------SPNSFLDQESRRRRFTIADSDQL----- 411

  Fly   417 DLVVPSWHERKPGIGSPTNCDPGSPSIRDKSISFGYGLEMAARPTTC------IGIA-------- 467
                       ||....||..|  ..:|:|:.|:|     ..||.:.      :||.
Human   412 -----------PGYSVETNILP--TKMREKTPSYG-----KPRPLSMPADGNWMGIVDPFARPRG 458

  Fly   468 -GDTSTDKARRMFHEARKLKQLTEDSQREFLVDRYKPGVSK-VVRFDAKEDYVMKNEKFICNVEN 530
             |....|...|.|...|....:.|.|...:...|  |...: :||   ..||:..:..:|    |
Human   459 HGRKGEDALCRYFSNERIPPIIEESSSPPYRFSR--PTTERHLVR---GADYIRGSRCYI----N 514

  Fly   531 TILETFEPIPFADEG 545
            :.|.:...|||.:||
Human   515 SDLHSSATIPFQEEG 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	29/72 (40%)
		SAM	7..74	CDD:197735	29/72 (40%)
		CRIC_ras_sig	82..165	CDD:287501	17/89 (19%)
		PDZ_signaling	206..283	CDD:238492	36/76 (47%)
		PH	720..814	CDD:278594
		PH_CNK_insect-like	720..810	CDD:270135
CNKSR3	NP_001355045.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158470
Domainoid	1	1.000	76	1.000	Domainoid score	I8964
eggNOG	1	0.900	-	-		E1_KOG1738
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2986
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1121556at2759
OrthoFinder	1	1.000	-	-		FOG0001221
OrthoInspector	1	1.000	-	-		otm42085
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12844
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3250
SonicParanoid	1	1.000	-	-		X1572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.930