DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cnk and cnk

DIOPT Version :10

Sequence 1:NP_725671.1 Gene:cnk / 36952 FlyBaseID:FBgn0286070 Length:1557 Species:Drosophila melanogaster
Sequence 2:XP_061510795.1 Gene:cnk / 1280124 VectorBaseID:AGAMI1_006694 Length:1844 Species:Anopheles gambiae


Alignment Length:1968 Identity:725/1968 - (36%)
Similarity:971/1968 - (49%) Gaps:537/1968 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAYINIAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVL 65
            |||||:|||:.|.||||:|||.:||..|:..|:...:||:.||||||||||.|||..||||||||
Mosquito     1 MAYINVAEWSTDMVTDWLKGLHDSMYHYVKSFTNNGVGGKQLLNIRPYELEQLGMHVIGHQEIVL 65

  Fly    66 EAVENLRNFHYHLKNDNLQFMALHVATAAKNLHRELARNHAESTKIDTRILHDITRTIATLKPLV 130
            ||||||:||:|:|..:||||:||||||||.:|.::|  ..::..|::|.:|.||||||..||.|:
Mosquito    66 EAVENLKNFNYNLDKENLQFLALHVATAAHSLGKQL--EFSDQEKLETAVLKDITRTITHLKALI 128

  Fly   131 GSLERTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLANFVIQDISD 195
            ..|:|.|||.|:.:.|.....::.|||:||:|.||||:|.||.||||:|::||::..::|:||.|
Mosquito   129 EWLDRAPFRGQKKFDELRKQCMRFGLEVATVAMRDRFSLMPVQAIRQNAKKLESIGEYIIKDIMD 193

  Fly   196 PMVLQPASLNLVTLKKRESELGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINYQTVV 260
            |::||||||:|||||||||:|||.|..:::|:||:|:||:|||||||||:|:|||||||||||||
Mosquito   194 PIILQPASLDLVTLKKRESDLGFLIMRNFHGVHRITEIKFNSPAHNSGKVEEGDEIVQINYQTVV 258

  Fly   261 GWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARWAAQMPSPRAAFL 325
            ||:::.|::.|:|:.|||:||:||||||.|::||||::|||||||||::..||...:|||||   
Mosquito   259 GWEYKKVVQQLQESPPDVLLTLKKRPKHMKIYGQIYIKPYRLPSKKRSLPYRWGESLPSPRA--- 320

  Fly   326 TLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDSDSSCSDIPTPTDPKLAAREIRL 390
             :||..|             :..:.....|..|..|    |||:|..|||.|.||.|.|.:||||
Mosquito   321 -MDTFAL-------------QDFTLPLERVPEKHVP----SDSESEGSDILTVTDAKEAEKEIRL 367

  Fly   391 YYPKPRALLQRRNTICGCEYLSLKNSDLV-VPSWHERKPGIGSPTNCDPGS--PSIRDKSISFGY 452
            |.|||||:||||:|:.     |.|  ||| |.||||  |..|.|.   |.|  .|:||||:|||:
Mosquito   368 YLPKPRAVLQRRHTLS-----SFK--DLVGVSSWHE--PQGGKPL---PSSDLQSLRDKSVSFGF 420

  Fly   453 GLEMAARP-TTCIGIAGDTSTDKARRMFHEARKLK----------------QLTE---------- 490
            |||||.|| |||:|:.|.::......  |.|...|                |.||          
Mosquito   421 GLEMAPRPTTTCLGLGGGSADGTGAN--HGAVPAKCNSFGGLQSSLPDIVPQETEAVAPPPNDLS 483

  Fly   491 ----------------DSQREFLVDRYKPGVSKVVRFDA--KEDYVMKNEKFICNVENTILETFE 537
                            ||      :.||.||||||||::  |.|....:.::.|.|::|:|||||
Mosquito   484 IVGARPGSGGSIEHGGDS------EAYKAGVSKVVRFESSTKADQCHVDTQYTCQVDSTVLETFE 542

  Fly   538 PIPFADEGDEDALETL-------------------RNCKTENAEELLEAIN-------------- 569
            |||:.   |||...|:                   |...|......:.::|              
Mosquito   543 PIPYV---DEDVPATVVQPPPTVTERVKRFESFASRTTTTAATAATIVSVNGQHGASDNSGTSNS 604

  Fly   570 ------LATKGQDLPL----------AEAINMPLL--QQGRRGRLDKSHSTPAYDNSGEESDTPP 616
                  ..|..:.:|:          |||||..::  :..:|||||||:||||||:  |.||.||
Mosquito   605 APGQTGSGTGSKPIPMQRHLAKEPEVAEAINTVVVNREMVKRGRLDKSYSTPAYDD--EHSDVPP 667

  Fly   617 AIEPRKEFLLVTPPAPPPRPRK-----------------------------------QREMTP-- 644
            |||||||.||..||.|||||::                                   .||.:|  
Mosquito   668 AIEPRKEHLLKAPPVPPPRPKRSLDPEKPPATPASASQLPEPTAAAGFVSSLSNALDSREDSPNK 732

  Fly   645 --------------------PAVPPPPP----------------KPASMQPASSITSISIPV-PV 672
                                |||.||.|                |||::.|.||....|.|. ..
Mosquito   733 SKLANVIDLKQNRTQPPLPAPAVTPPKPAERTAVPPVPAARPDAKPAAITPPSSEPPTSSPTSSA 797

  Fly   673 PVPAAVDPSEIS-ELHTPSKSRTLTLKKKHSLMAKRRNTNLKLLGTGDIQGHLYRRKKNHRGVTY 736
            .||:.|.|::.| ||.||:|:::||||||:||::||||.:||.|...|||||||||.|:..|::|
Mosquito   798 TVPSIVPPTDTSTELLTPNKTKSLTLKKKNSLLSKRRNVSLKTLCVSDIQGHLYRRTKDRSGMSY 862

  Fly   737 WARIYFVMLDTILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYHTAKSFYFAAESLD 801
            ||:.|||:::|.|||||||||..|:.:|||.|||:||||||||:||||||||..|:||||||:.|
Mosquito   863 WAKHYFVLIETTLYGFRSKQSPKANSMIFLSGFTISLAKEVHSRPHAFKVYHPHKTFYFAAETQD 927

  Fly   802 ALNQWVDFLRQASLKVPPST---GSKGGG--------DAKDLYSENDSSGEECDAL--VIQNLST 853
            ||.||:::::||:||...:.   ||.|||        :|::||||.|||.:|...:  ....|.|
Mosquito   928 ALVQWMEYIKQATLKGASTVVAGGSTGGGSSSADHHHNARELYSETDSSDDEIGIMDSTQSLLCT 992

  Fly   854 PSPQGNKESMSMSMTLSGG---------TPPSSAPIKHERGY---LDSFRKFTNTFKSSAA---- 902
            ||||         ::.:||         |.|:.:..||:..|   ..|.:|.|....|.|.    
Mosquito   993 PSPQ---------LSGAGGGSGSHGGSDTTPTGSSSKHDHRYHLNFGSLKKLTKLGSSDAGHHGS 1048

  Fly   903 ------------------------------------------KPSSDIPVPTEQYRSYRKVPGGS 925
                                                      ..||::||||.:::|||||||.:
Mosquito  1049 SSAGSAAAASAAASSTGSGGSGTASEGSKFFSFFSSHRSVEKSNSSEVPVPTSKFKSYRKVPGSA 1113

  Fly   926 FGIQIGANTPGYHDPAMPPTQIPPLVGPKLSRSSSRSSVVSGTESAVS------LSASILG---- 980
            .|:|||.       .::||..:..:|.....|.....|....|.|.::      |.:.:.|    
Mosquito  1114 GGLQIGT-------ASVPPETVSTVVNGVTIRHFKGGSFTGSTVSLLTALEPGELESVLAGYDQS 1171

  Fly   981 -PPASPAPTPTPTATPTSLQHQSSEESPSQSQSQSPSSKSSLKKAPFNFLHASNPNLVEFDFHTS 1044
             .|.:|.|.|.|...|...:.|.   .|:..::.....::..:.:|:|::||||||||||||.||
Mosquito  1172 LEPPTPPPLPPPPVPPVKFRLQG---PPTIIEAAKRLKRTRKRISPYNYIHASNPNLVEFDFQTS 1233

  Fly  1045 KTL---LPKMSVGNTLD-----HGHNIQGFVTLKDLMLRKQEEEAQEMYNNRVHLGVEK--HKHA 1099
            |.:   :||:..|:|.|     ||.|:|..:|||||||:||.||||:|||.||.|||||  .:.|
Mosquito  1234 KAMDFSVPKIHAGSTWDNGAHTHGGNLQSMITLKDLMLQKQAEEAQDMYNKRVCLGVEKLDDRKA 1298

  Fly  1100 R----------TESTASQQSAMSSSVTKPLEKLP----KIQSVSLPKTPDYEISFKPDDESIKRT 1150
            |          .|..||.....:.:...|...:|    |||...||.||||..|||.||..|..|
Mosquito  1299 RLGGGGGGMSGAEQFASGPGGPAGAGPPPQPAIPEEVNKIQRRRLPNTPDYAQSFKLDDADILYT 1363

  Fly  1151 RTKEGQKLRDFGYELICGDEP--------------ST------SSISRQEHHH--HHHHHQHHLQ 1193
            |:||||||||||||:|.||:|              ||      ||::...:..  .:.::..|..
Mosquito  1364 RSKEGQKLRDFGYEMISGDDPFDQRNKPIRSTVGGSTGASVLSSSVAAGANGSGGGNGNNGTHAN 1428

  Fly  1194 HVQ---------QQQQLQHQQTQQQHSSKAKHFLR----------------SQQLQLSSFLHKNS 1233
            ...         :::......::::.|:.....:.                |..|..:...|..:
Mosquito  1429 GTSTGGGGGGSIKKKTFNWMNSERKGSNAGDTTIHDGAAAGGSYPIGSASSSSSLFAAPSEHHRT 1493

  Fly  1234 SGGSGKSSGSGADQ-KKSKG----------KSSGDRRFPFSKHSTGSAGSG-------------- 1273
            .||...:|.|..|. |:||.          |:|.::.|.| |.|:|:.||.              
Mosquito  1494 GGGGLVASLSLRDSFKRSKNKAVIARFDNIKASSEKLFQF-KQSSGTGGSSGSNNNNDKESLKTK 1557

  Fly  1274 -----CGPGHAMTMTL------------PLNKKSKSNH--------------------ALDGAVG 1301
                 ..||.|:.:.|            .|..|..||.                    |..||..
Mosquito  1558 QLDKPAAPGSAVNVNLKHQAAAASISVGALGGKKNSNELNATLDKHIALLFQQQQQPAAAPGAAA 1622

  Fly  1302 NGVTIIGSGSSIKKSQTYNQDLRDKIVGTKYDAHRKNSAP--------------IPIFSKLSISG 1352
            ..|......:.||||.|.|.....|....|....||||||              ...|:|||. |
Mosquito  1623 GKVVAASHSALIKKSNTCNSSSDFKENSAKLQNMRKNSAPERGAAGGGSGSNGGTSYFTKLSF-G 1686

  Fly  1353 GTPAKPSKENRFLGSPLLHRTLFGHHHHQQQAVTPPSSADPDCDQEIFSQITLPTHNQAGYRSY- 1416
            .|  |..||.:.||||.|||.:||.:||.|.:.:.|:.    .|.|:||.|           || 
Mosquito  1687 ST--KTPKEKKLLGSPGLHRAIFGKNHHHQGSDSQPTV----IDHEVFSPI-----------SYT 1734

  Fly  1417 RGPGILTTSTTNLCSSEGLQPPLPPAPPPPVNTSRQREEEQAEATISECAATPKVSSSGSVDS-- 1479
            :.|..|.|.... .||.......|....||                  ..|||..|::..:.|  
Mosquito  1735 KAPAALPTDAGG-SSSSSTAATTPTGTGPP------------------AVATPGSSAAVLIPSFG 1780

  Fly  1480 ------KAATPDYPNMECPPVFEPEIYSLSDTSLSRIVMRTPSSSGATSATASTTTTNNNNNNNN 1538
                  ..::|||||||.|||||||:|||||.:.|..:::                    ...|:
Mosquito  1781 PNFPPVPRSSPDYPNMEYPPVFEPEMYSLSDPNASLTLLK--------------------RRQNH 1825

  Fly  1539 TNNNTNTNSSPSGGEHHQ 1556
            .:::...:..|....|||
Mosquito  1826 HHHHQPHSHHPHHQHHHQ 1843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cnkNP_725671.1 SAM_CNK1,2,3-suppressor 6..74 CDD:188910 44/67 (66%)
CRIC_ras_sig 82..165 CDD:463138 39/82 (48%)
PDZ_CNK1_2_3-like 203..283 CDD:467230 54/79 (68%)
PH_CNK_insect-like 720..810 CDD:270135 61/89 (69%)
cnkXP_061510795.1 None

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