Protein Alignment cnk and fgd5b

DIOPT Version :10

• Sequence 1: NP_725671.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: NP_001352385.1
• Gene: fgd5b / 101884144
• ZFINID: ZDB-GENE-130925-3
• Length: 1299
• Species: Danio rerio
• Alignment Length: 800
• Identity: 140/800 - (17%)
• Similarity: 254/800 - (31%)
• Gaps: 308/800 - (38%)

  Fly   274 ALPDVVLTVKKRPKHTKMFG-QIYMQPYRLPSKK--------RNMAARWAAQMPSPRAAFLTLD- 328
            ::|:.:....|:|.    || :.|:.|.|...|.        |::::|.::: .||:.:...:|
Zfish   549 SIPNEISASCKKPD----FGFKRYLLPLRFLRKSDRKSMMDTRSISSRSSSE-SSPQGSCRRMDF 608

  Fly   329 ------TEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDSDSSCSDIPTPTDPKLAARE 387
                  :.:|......:....||..||...|    :...::.:.::|.:||.|  ..:|...:..
Zfish   609 IRHNMGSPELQRSPDCTPPVSPSSFLSHRNR----RKEGLNFSLNNDLACSSI--SIEPGFLSEP 667

  Fly   388 IRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHER------KPGI------GSPTNCD--- 437
            :.|  .|||: ....|| ...||.:::|    |.|.:|.      .|.|      .||::.|
Zfish   668 LPL--SKPRS-FSSPNT-DSSEYENVQN----VASHYENVQIRLLNPVIQGQRNQSSPSDTDGYV 724

  Fly   438 -----PG-------------------SPSIR-DKSISFGYGLEMAARPTTCIGIAGDTSTDKARR 477
                 ||                   ||::| |.::....|:..|....|   .|.|..|....|
Zfish   725 DMSSLPGFQGKSQSSEQETDSLYTFCSPNVRADGTVGVFVGVACAQEKKT---TAPDKLTVSCSR 786

  Fly   478 MFHEARKLKQLTEDSQ-----------------------------------REFLVDRYK----- 502
            .|:.|::|  |..::|                                   ...|..|.|
Zfish   787 AFYSAKEL--LDSEAQHVKTLQLLYESVNADERLMTVWTEVPDICTLHQDIHTLLETRLKEWDQN 849

  Fly   503 PGVSKVV-----RFDAKEDYVMKNE---KFICNVENTI--------------------------- 532
            .|:::::     .|.....|:...:   .::.::::|:
Zfish   850 EGIAEIILAKKTEFSIFSSYISHYDDKLNYLEHIQSTLSDSVTLKKQLLQVIVRILQYRMLLTDY 914

  Fly   533 LETFEPIPFADEGDEDALETLRNC------KTENAEELLEAINLATKGQDLPLAEAINMPLLQQG 591
            |....|.....|..:|||..:.:.      ..:|..:|:..:::  :...|.|.:     |:|.|
Zfish   915 LNNLSPDSREFENTQDALVVVSDVAYHASDSLKNGADLMRLVHI--EHSVLGLTD-----LIQPG 972

  Fly   592 R----RGRLDKSHSTPAYDNSGEESDTPPAIEPRKEFL-----LVTPPAPPPRPR--KQREMTPP 645
            |    .|.|.|.              :....:||..||     |.|.|....:.|  .:..:...
Zfish   973 RVFVKEGTLMKV--------------SRKCKQPRHLFLMNDIMLYTYPQQDGKYRLINRLPLAGM 1023

  Fly   646 AVPPPPPKPASMQPASSITSISIPVPVPV-------------------PAAVDPSEISEL-HTPS 690
            .|..||.:.|.......:..|||.:....                   .|:.||.:..|| .:|.
Zfish  1024 KVSKPPMESAQSAIKIEVKDISITLSASSCIERDGWFVTMNRTLVDLGSASGDPVDSFELVESPE 1088

  Fly   691 KSR-----------------------TLTLKKKH------------------------------- 701
            |..                       :||.::.|
Zfish  1089 KCLGENAPPLLSVSQVTVCMNCPSHFSLTNRRHHCHACGKVVCRDCCRNKFPLKYMKNRRAKVCD 1153

  Fly   702 --------------------------------SLMAKRRN--TNLKLLGT-GDIQGHLYRRKKNH 731
                                            ||...|:.  |..::.|: |.:.|.|.|.:.:.
Zfish  1154 HCYTELRKNDVATVIEGSSRPLSAVFQNIHPSSLWRSRKGQLTFNQVTGSEGVMSGTLQRCRNSK 1218

  Fly   732 RGVTYWARIYFVMLDTILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYHTAKSFY-F 795
            |.   |..::|::.|.:||.:...:...|...:.|.||  |:..|...:...|::||.:..|| |
Zfish  1219 RS---WRSLWFLLKDKVLYTYPQPEERVACETLPLLGF--SVRSEAEGESSVFQLYHKSTLFYTF 1278

  Fly   796 AAESLDALNQWVDFLRQASL 815
            .|:......:||:.:.:|::
Zfish  1279 RAQDSHTAQRWVNAMEEATV 1298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_725671.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910
		CRIC_ras_sig	82..165	CDD:463138
		PDZ_CNK1_2_3-like	203..283	CDD:467230	1/8 (13%)
		PH_CNK_insect-like	720..810	CDD:270135	24/90 (27%)
fgd5b	NP_001352385.1	RhoGEF	791..941	CDD:459876	17/151 (11%)
		PH-like	962..1069	CDD:473070	24/125 (19%)
		FYVE_like_SF	1096..1161	CDD:333710	3/64 (5%)
		PH2_FGD5_FGD6	1207..1293	CDD:270057	24/90 (27%)