DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cnk and LOC100488567

DIOPT Version :9

Sequence 1:	NP_001286524.1	Gene:	cnk / 36952	FlyBaseID:	FBgn0286070	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	XP_031747178.1	Gene:	LOC100488567 / 100488567	-ID:	-	Length:	1053	Species:	Xenopus tropicalis

Alignment Length:	1272	Identity:	312/1272 - (24%)
Similarity:	483/1272 - (37%)	Gaps:	369/1272 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            |::|:|.||.||:||||:.::.|:..|.:::|.|..||:|...|||.||:.||||||::||||:.
Frog     8 ISKWSPKQVVDWMKGLDDCLQQYIKNFEREKINGEQLLHITHQELEELGVTRIGHQELILEAVDL 72

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELA----RNHAE---STKIDTRILHDITRTIATLKP 128
            |...:|.|:.:||:.::..:..:||||...:.    ..|.:   |.::....|..:...|...|.
Frog    73 LCALNYGLETENLRTLSHKLNASAKNLQNFITGRRRSGHYDGRASRRLPNDFLTSVVDLIGAAKN 137

  Fly   129 LVGSLERTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLANFVIQDI 193
            |:..|:|:||.....|.....|:::..|||.||..:|....:....|....:.|..:.:.:|...
Frog   138 LLAWLDRSPFVSVTEYSLLKNNIVQLCLELTTIVQQDCTVYETENKILHVCKTLSGICDHIISLS 202

  Fly   194 SDPMVLQPASLNLVTLKK-RESE-LGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINY 256
            ||.:|.|.|.|.:|.|.. ..|| ||..|:|:|:|:|.:|....||||....||..|||::|:|:
Frog   203 SDSLVSQSAHLEVVHLTNIMPSEGLGMYIKSTYDGLHVITGTTENSPADQCKKIHAGDEVIQVNH 267

  Fly   257 QTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARW--AAQMP- 318
            |||||||.:.::..|||....|:||:||||::|..         ..|:..:|:  ||  .|..|
Frog   268 QTVVGWQLKNLVNALREDPNGVILTLKKRPQNTLA---------SAPALLKNV--RWKPLALQPL 321

  Fly   319 ---SPRAAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSA-SDSDS----SCSDI 375
               ||.:...|      .||..|.:    ||..||...:|.. .:|||.. ...|.    ||.||
Frog   322 IPTSPTSGNTT------PTGTIGMS----SKVDSSNLHDVFI-LSPVSGLYGPRDEIGIVSCDDI 375

  Fly   376 PTPTDPK--LAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGIG------S 432
            ......|  :...|...||      |:..:   |..|..::.....|.|.:||....|      :
Frog   376 NKYGVGKSGMKGSESPSYY------LEHES---GKYYTLIEGEGHQVGSEYERGRSTGVRRREKT 431

  Fly   433 PTNCDPGSPSIRDKSISFGYGLEMAARPT--TCIGIAGDTSTDKARRMFHEARKLKQLTEDSQRE 495
            ||:.|                |...:.||  :.:|.:.:.:..|......|...|:.|::|   :
Frog   432 PTHGD----------------LRPVSMPTEYSWLGESKEPNMYKRGSRDSENSLLRYLSDD---K 477

  Fly   496 FLVDRYKPGVSKVVRFDAKEDYVMKNEKFICNVENTILETFEPIPF-------ADEGDEDALETL 553
            .||.:.:|    |.:.|.|.|...::.|   ..:||...::...|.       .|...:|.|
Frog   478 ILVIQEEP----VTQKDNKRDTGRRSRK---KGKNTGSPSYPISPSMLTSTGRLDPAQQDVL--- 532

  Fly   554 RNCKTENAEELLEAINLATKGQDLPLAEAINMPLLQQGRRGRLDKSHSTPAYDNSGEESD--TPP 616
                                  ...|||:..:||.           |.|.  |..|.:|:  |..
Frog   533 ----------------------TFSLAESNTVPLY-----------HRTG--DTLGGDSERYTTS 562

  Fly   617 AIEPRKEFLLVTPPAPPPRPRKQREMTPPAVPPPPPKPASMQPASSITSISIPVPVPVPAAVDPS 681
            |.|                                        ...|||:.
Frog   563 AAE----------------------------------------RQGITSMR-------------- 573

  Fly   682 EISELHTPS-KSRTLTLKKKHSLM-AKRRNTNLKLLGTGDIQGHLYRRKKNHRG--VTYWARIYF 742
              ...|:.| :.||....|..||. ..||..:.|.||.||.:|.|: :||:.:|  ...|.:.:|
Frog   574 --KSFHSASLRVRTKKRSKGSSLTGGSRRRISCKDLGHGDCEGWLW-KKKDAKGYFTQKWKKYWF 635

  Fly   743 VMLDTILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYH-TAKSFYFAAESLDALNQW 806
            ::.|:.||.:.::....|...|.||.|.:..|.|...| ||||..| ..|||:||.:.|:.:|:|
Frog   636 ILKDSSLYWYTNQNDEKAEGFISLPEFRIDRAIECRRK-HAFKACHPKIKSFFFATDCLEEMNRW 699

  Fly   807 VDFLRQASLKVPPSTGSKGGGDAKDLYSENDSSGEECDALVIQNLSTPSPQGNKESMSMSMTLSG 871
            ::.|..|::...|........:| |.:||:|                      ::.:..||||..
Frog   700 MNRLGLAAIGYTPDEKDTRPNEA-DYWSESD----------------------QDDIDGSMTLRQ 741

  Fly   872 GTPP---SSAPI---KHERGYL-----------DSFRKFTNTFKSSAAKPSSDIPVPTEQYRSYR 919
            ..|.   ||:|.   ||.|.:.           ||.:..|.:..||..:||         ||..|
Frog   742 EAPSTVNSSSPFPEPKHGRHFSSESTYSHSSAEDSRQDATGSTHSSGCRPS---------YRERR 797

  Fly   920 ------KVPGGSFGIQIGANTPGYHDPAMPPTQIPPLVGPKLSRSSSRSSVVSGTESAVSLSASI 978
                  :.|..|.|:......|                       |....||..|
Frog   798 SWQDLIETPLTSSGLHFLQTVP-----------------------SDGEYVVGHT---------- 829

  Fly   979 LGPPASPAPTPTPTAT-PTSLQHQSSEESP-----------SQSQSQSPSSKSSLKKAPFNFLHA 1031
                 ..:|.....|| |...:|.:..:.|           |.:::|...|:|
Frog   830 -----GMSPEQRRQATLPVQRRHNNERDGPFPLTECPRGHTSHARTQKQRSQS------------ 877

  Fly  1032 SNPNLVEFDFHTSKTLLPKMSVGNTLDHGHNIQGFVTLKDLMLRKQEEEAQEMYNNRVHLGVEKH 1096
                            ||:.........|.|.:           |.||::::..:.|.|...:|.
Frog   878 ----------------LPRNRDVRVKSRGKNTE-----------KLEEKSEDELSKRTHSNSDKE 915

  Fly  1097 KHARTESTASQQSAMSSSVTKPLEKLPK-IQSVSLPKTPDYEISFKPD--------------DES 1146
                 ||...::|:     |..|::|.| ::..||....:..:|.|.:              :|.
Frog   916 -----ESKKEKRSS-----TDGLQELYKTLEQASLSAFGEQRLSTKQEFRRSFIKRCNDPIMNEK 970

  Fly  1147 IKRTRT-KEGQKLRDFGYELICG--DEPSTSSISRQE 1180
            :.|.|. |...|.::....:|..  ::|..||...:|
Frog   971 LHRIRVLKSTVKAKEGDLAIINSLLEDPQLSSKKLKE 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	34/67 (51%)
		SAM	7..74	CDD:197735	33/66 (50%)
		CRIC_ras_sig	82..165	CDD:287501	23/89 (26%)
		PDZ_signaling	206..283	CDD:238492	36/78 (46%)
		PH	720..814	CDD:278594	32/96 (33%)
		PH_CNK_insect-like	720..810	CDD:270135	31/92 (34%)
LOC100488567	XP_031747178.1	SAM_CNK1,2,3-suppressor	8..76	CDD:188910	34/67 (51%)
		CRIC_ras_sig	84..176	CDD:402249	24/91 (26%)
		PDZ_signaling	223..294	CDD:238492	34/70 (49%)
		DUF1170	339..520	CDD:399567	48/220 (22%)
		PH_CNK_mammalian-like	598..710	CDD:269962	40/113 (35%)
		PRK03918	<894..>1011	CDD:235175	27/135 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8694
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3021
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1121556at2759
OrthoFinder	1	1.000	-	-		FOG0001221
OrthoInspector	1	1.000	-	-		otm49316
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1572
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.970