Protein Alignment cnk and farp1

DIOPT Version :10

• Sequence 1: NP_725671.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: XP_017211441.1
• Gene: farp1 / 100329707
• ZFINID: ZDB-GENE-070424-163
• Length: 1041
• Species: Danio rerio
• Alignment Length: 799
• Identity: 158/799 - (19%)
• Similarity: 261/799 - (32%)
• Gaps: 303/799 - (37%)

  Fly   261 GWQHRTVLEHLREALPDVVLTVKKRP---KHTKMFGQIYMQPYRLPSK----------KRNMAAR 312
            |...|.|::::::.      ..||.|   ||:|:.....:.|:  ||:          :||.:|.
Zfish   343 GRTQRQVIDYVKDT------EFKKVPFERKHSKIQSNSNLSPF--PSRQSAEGQGEMLQRNASAS 399

  Fly   313 WAAQMPSPRAAFLTLDTEQLATGGTGSAVPDP-----SKSLSSEKREVLTKANPVSSASDSDSSC 372
             ..|..||             .|.|...|.:|     :.||:|:       .|...:.:..::..
Zfish   400 -GHQADSP-------------LGRTQVTVENPALQRYTGSLNSQ-------TNGCRNGTSDEADA 443

  Fly   373 SDIPTPTDPK-------LAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVV---PSWHERK 427
            ...|:|:..:       ||:...:  .|..|:.....:...|...::.:...|.|   |...:..
Zfish   444 RLKPSPSKQQAEHLSTGLASHSAK--GPVSRSPQHSESPSAGQMMVNGQKQSLSVGQSPDGRQPS 506

  Fly   428 PGIGSPTNCDPG------SPSIRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLK 486
            | :.||...|.|      ...:|.|..                      .||||   :..|::|
Zfish   507 P-LTSPLLYDAGFIRADDEDEVRRKRF----------------------PTDKA---YFIAKEL- 544

  Fly   487 QLTEDSQREFLVDRYKPGVSKVVRFDAKEDYVMKNEKFICNVENTILETFEPI-PFAD------- 543
             ||  ::|.:|.|.....||       .:..|:|:|....::.|.|...|||: .|.:
Zfish   545 -LT--TERTYLKDLEVITVS-------FQKAVLKDEAMPDSLRNLIFANFEPVYKFHETFLKDVE 599

  Fly   544 ------EGDEDA-------------------LETLRNCKTENAEELLE-------AINLATKGQD 576
                  ||..:|                   |:.|.:...:::|.|||       :..|....:|
Zfish   600 QRLAQWEGRSNAHIKGDYQRVGDVMLKNIQGLKLLSSHLQKHSESLLELEQSCRSSRRLEVLCRD 664

  Fly   577 LPLAEAINMPL----LQQGRR--------GRLDKSHSTPAYDNSGEESDTPPAIEPRKEFLLVTP 629
            ..|.:...:||    |:...|        .||.| |..|.:|:.
Zfish   665 FELQKVCYLPLNIFFLRPLHRLLHYKQILERLCK-HYPPTHDDF--------------------- 707

  Fly   630 PAPPPRPRKQREMTPPAVPPPPPKPASMQPASSITSISIPVPVPVPAAVDPSE-ISELHT----- 688
                   |..|                                  .|..|.|| :.:|||
Zfish   708 -------RDSR----------------------------------AALADVSELVLQLHTTLMKM 731

  Fly   689 PSKSRTLTLKKK----HSLMAK-----RRNTNLKLLGTGDIQGHLYRRKKNHRGVTYWARIYFVM 744
            .:..:.|.|||.    .||.|.     |.....||.|.|..|                 |::|:.
Zfish   732 ENFQKLLELKKDLVGIDSLAAPGREFIRLGCLSKLSGKGLQQ-----------------RMFFLF 779

  Fly   745 LDTILYGFRSKQSTSASLV---IFLPGFTVSLAKEVHSKPHAFKVYHTAKSFYFAAESLDALNQW 806
            .|.::|..|...:::...|   :.|.|.|:..:::....|::|.::...:|...||.|...:.:|
Zfish   780 SDVVMYTSRGLTASNQFKVHGQLPLYGMTIRESEDEWGVPYSFTLFGQRQSVVVAASSASEMEKW 844

  Fly   807 VDFLRQASLKVPPSTG------SKGGGDAK-------DLYSENDSSGEECDALVIQNLSTPSP-Q 857
            ::.:|.|......|.|      |....|:|       |..||:|.|...      .:|...:| :
Zfish   845 IEDIRMAIELADKSNGPTTEILSSSFSDSKSPEDCSADQESEDDLSSSR------SSLERQTPHR 903

  Fly   858 GN-------KESMSMSMT---------LSGGTPPSSAPIKHERGYLDSFRKFTN----TFKSSAA 902
            ||       ..|.|:||.         |||..   ....|:..|:...:..|||    .:|:...
Zfish   904 GNTTVHVCWHRSTSVSMVDFSVALENQLSGNL---LRKFKNSNGWQKLWVVFTNFSLFFYKTHQD 965

  Fly   903 K-PSSDIP-------VPTE 913
            : |.:.:|       :|:|
Zfish   966 EYPLASLPLLGYSITIPSE 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_725671.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910
		CRIC_ras_sig	82..165	CDD:463138
		PDZ_CNK1_2_3-like	203..283	CDD:467230	3/21 (14%)
		PH_CNK_insect-like	720..810	CDD:270135	17/92 (18%)
farp1	XP_017211441.1	FERM_F1_FARP1	41..125	CDD:340709
		FERM_B-lobe	133..223	CDD:271216
		FERM_C_FARP1-like	218..339	CDD:270014
		FA	331..374	CDD:462582	9/36 (25%)
		RhoGEF	538..720	CDD:238091	45/255 (18%)
		PH1_FARP1-like	750..858	CDD:269928	26/124 (21%)
		PH2_FARP1-like	927..1024	CDD:270055	13/61 (21%)