Protein Alignment cnk and fgd5a

DIOPT Version :10

• Sequence 1: NP_725671.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: XP_021335470.1
• Gene: fgd5a / 100151562
• ZFINID: ZDB-GENE-090428-3
• Length: 1473
• Species: Danio rerio
• Alignment Length: 1021
• Identity: 198/1021 - (19%)
• Similarity: 323/1021 - (31%)
• Gaps: 333/1021 - (32%)

  Fly   345 SKSLS----SEKREVLTKANPVSSASDSDSSCSDIPTPTDPKLAAREIRLYYPKPRALLQRRNTI 405
            |||..    :|.|||      :.:..:..|:||:..|.|.
Zfish   136 SKSADDIKPAESREV------IYNVLEDTSACSENDTSTK------------------------- 169

  Fly   406 CGCE----YLSLK----NSDLVVPSWHERKPGIGSPTNCDPGSPSIRDKSISFGYGLEMAA---- 458
             .||    |..::    ||.......:|.  .||:..||      :..::...|.||...|
Zfish   170 -ACESQSPYEEIEEPPLNSFQCANGQYEE--DIGAGANC------VHHEAEEDGTGLSSKATNCS 225

  Fly   459 RPTTC-------IGIAGDTSTDKARRMFHEAR---KLKQLTEDSQREFLVDRYKPG--------- 504
            :|:.|       ||...|.:|.:|.|...:..   :..:.|||:...:.|....|.
Zfish   226 QPSLCEEYPYDIIGTLDDNNTWQAERATKDPSGRFRFAEETEDAFEPYSVIEVVPSDLMCTADPE 290

  Fly   505 -------VSKVVRFDAKED----------YVMKNEKFICNVENTILETFEPIP------------ 540
                   .|.|...|::..          ||...:......|...||....:|
Zfish   291 TRCTDEESSNVKPMDSENTTEGTSNQEPYYVSSEDVEDLEEEQAKLENGVSLPASEVQEMDKNEE 355

  Fly   541 ---FAD----EGDEDALETLRNCKTENAEEL---LEAINL--ATKGQDLPLAEA----------- 582
               :||    |||:..:|.   ..:|:..|:   .|.:|:  .|||:.:....|
Zfish   356 VDDYADIEDHEGDDHQVEC---ASSEDYVEIGDEDEPLNMERKTKGKSVRERSARRRHDLLSQRN 417

  Fly   583 ----------INMPL-LQQGRRGRLDK----SHSTPAYDNSGEESD--TPPAIEPR--------- 621
                      |.:|. |..||...|..    :|:|.|::...||.|  ..|..|..
Zfish   418 SCQPRLRLCNITVPADLDLGRTPELTNRVVFAHTTEAFEEDIEELDCHIVPFFEDSDTESDEHIY 482

  Fly   622 ---------KEFLLVTPPAPPPRPRKQREMTPPAVPPPPPKPASMQPAS-SITSISIPV---PVP 673
                     :.|:.:...:...|.|......|..||...|:....:..| ...::::..   |.|
Zfish   483 EEAGFDSEGENFISLDRKSIVTRSRSLSGKVPGYVPETVPEETGTEYQSHDYYTVALDQNGDPHP 547

  Fly   674 VPAAVDPSEISELHTPSKSRTLTLKKKHSLMAKRRNTNLKLLGTGDIQGHL-----YRRKKNHRG 733
            .|:  |.:|.:.:....|.|...|..: ||..:.|:..|    :|..:|..     ||.::....
Zfish   548 KPS--DEAEANRIIPSLKPRRFLLSPR-SLSVEGRDLQL----SGHFEGEKSLREEYRLQRKDDT 605

  Fly   734 VTYWARIYFVMLDTILYGFRSKQSTS-----ASLVIFLPGFTVSLAKEVHSKPHAFKVYHTAKSF 793
            ::    :..|:..:..:..||.||:|     .|||...|.|.::.   :..:|    |..::.|.
Zfish   606 LS----LPCVITSSGSFSQRSHQSSSGVSTPTSLVDIPPPFELAY---ITKRP----VTKSSPSL 659

  Fly   794 YFAAESLD-ALNQWVDFLRQASLKVPPSTGSKGGGDAKDLYSENDSSGEECDALVIQNLSTPSPQ 857
            ....:|.| ...:...|.|..:||....:.||..||.....|.:.|.......:.:..|...|..
Zfish   660 LIQHDSPDNPKKKKTSFKRFLALKFRKKSESKSRGDGSVRSSRSSSESSHHGPIRVLELDRRSTS 724

  Fly   858 GNKESMSMSMTLSGGTPPSSAPIKHERGYLDSFRKFTNTFKSSAAKP--SSDIPVPTEQYRSYRK 920
            |:.:                                   .:|.|.||  :|:||.....|:..:.
Zfish   725 GSPK-----------------------------------LQSHAGKPQRNSEIPTTFLLYKERQS 754

  Fly   921 VPG-----GSFGIQIGANTPGYHDPAMPPTQIPPLVGPKLSRSSSRSSVVSGTESAVSLSA---S 977
            ..|     .|.||   :....:.|...||....||..|:  ..|..|:..|..|:..::|:   :
Zfish   755 RQGALKSYNSRGI---SRVESFEDRTRPPFMPLPLTKPR--SISFPSADTSDYENIPAMSSDYEN 814

  Fly   978 ILGPPASPAPTPT---------PTATPTS-------LQHQSSEESPSQSQSQSPSSKSSLKKAPF 1026
            |..|...|....|         .||.|.:       :...:..|:.|.::.|...|..:   .||
Zfish   815 IQIPHGRPTRAVTITEFFDDHNRTAAPANENDGYVDMNSFAGIENKSTTREQDTESAYT---EPF 876

  Fly  1027 NFLHASNPNLVEFDFHTSKTLLPKMSVGNTLDHG-------------HNIQ------GFVTLKDL 1072
            .....|                  .:|.|..|||             |:.|      .:...|||
Zfish   877 PVCPVS------------------ATVSNEEDHGRTSEEEDGCGDHCHDRQIDGRSRAYYVAKDL 923

  Fly  1073 MLRKQE-----EEAQEMYNNRVHLG-------VEKHKHARTESTASQQSAMSSSVTKPL------ 1119
            :..::|     :..||.:...|..|       :|..|.....||..|..::.|.:...|
Zfish   924 VDSEREHVKALKVLQEDFRAAVESGGDDNGPLIENGKLDEIFSTLPQAYSLHSEILNELETRIKQ 988

  Fly  1120 -EKLPKIQSVSLPKTPD----------YEISFKPDDESIKRTRTKE 1154
             |..|.:..|.|.:..:          |:.|....|||.::::..|
Zfish   989 WEDSPTVVDVILTRRAEFSSFATYISNYDRSMSVLDESCRKSQAFE 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_725671.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910
		CRIC_ras_sig	82..165	CDD:463138
		PDZ_CNK1_2_3-like	203..283	CDD:467230
		PH_CNK_insect-like	720..810	CDD:270135	19/100 (19%)
fgd5a	XP_021335470.1	PTZ00341	<25..149	CDD:173534	4/12 (33%)
		RhoGEF	919..1102	CDD:459876	25/116 (22%)
		PH1_FGD5	1121..1243	CDD:275435
		FYVE_FGD5	1255..1321	CDD:277281
		PH2_FGD5_FGD6	1377..1467	CDD:270057