Protein Alignment cnk and cnksr1

DIOPT Version :9

• Sequence 1: NP_001286524.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: XP_031751525.1
• Gene: cnksr1 / 100144653
• XenbaseID: XB-GENE-493182
• Length: 885
• Species: Xenopus tropicalis
• Alignment Length: 1074
• Identity: 240/1074 - (22%)
• Similarity: 379/1074 - (35%)
• Gaps: 296/1074 - (27%)

  Fly    19 KGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVENLRNFHYHLKNDNL 83
            :.||.:::  :|.|.:..:.|:.||.:...:|:.||:..||||||:|||:|.|...||.|..:||
 Frog    24 QSLDPAVQ--VYTFQEWNVTGKDLLCLSSQQLDALGVRCIGHQEIILEAIEQLCALHYELHAENL 86

  Fly    84 QFMALHVATAAKNL--H----RELARNHAESTKIDTRILHDITRTIATLKPLVGSLERTPFRKQE 142
            :.:...:...:::|  |    |::| :|:.|.....:.|..|...:|..:.|...|.|..|.:..
 Frog    87 RSLTEKLYGVSQSLWSHILSMRKVA-SHSLSAAPTPKQLVCIIDIVAAARGLFSWLNRYLFARLN 150

  Fly   143 MYREYCGNVLKCGLELATIAHRD----RFALQPVPAIRQSAERLENLANFVIQDISDPMVLQPAS 203
            .|......::.| ||||...|:|    ....:.|...:......|::.|...:|:.:    |.|:
 Frog   151 DYSASRDVIVLC-LELAESVHKDWSDPHVESRVVSICQNICGTCESILNCSPEDLLN----QTAT 210

  Fly   204 LNLVTLKKR--ESELGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINYQTVVGWQHRT 266
            |..|.:|..  ...||..|:|:..|.|.|......:||..||||..||||:::|.|.||||..:.
 Frog   211 LEPVLIKPELPHYNLGIEIKSTSLGQHFVCGTTAEAPAGRSGKIFPGDEIIKVNDQVVVGWTRKN 275

  Fly   267 VLEHLREALPDVVLTVKK--------RPKHTKMFGQIYMQPYRLPSKKRNMAARWAAQMP----S 319
            ::..|:|....|.|.:||        .|.....|.|        .|.|..:.|.....:|    :
 Frog   276 LVYKLQEKTDCVTLVLKKVSIPSTSVSPTSPTYFIQ--------HSSKTTLTAHSEPSLPKAEIT 332

  Fly   320 PRAAFLTLDTEQLATGGTGSAVPDPSKSL-----SSEKREVLTKANPVSSASDSDSSCSDIPTPT 379
            |.||                |...||..:     |:|.|  .|::.||:...|:.|..:.....|
 Frog   333 PVAA----------------ARQSPSHLILALRKSTETR--TTRSAPVTPTKDTPSVLNLNSVST 379

  Fly   380 DPKLAAREIRLYYPKPRALLQRRNT-ICGCEYLSLKNSDLVVPSWHERKPGIGSPTNCDPGSPSI 443
            .|         .:....:...:.|| |...:..|.:|||.::.:            || |.||:
 Frog   380 SP---------VFSDKFSFTNKHNTDISQNQDSSQQNSDTILSA------------NC-PWSPT- 421

  Fly   444 RDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQREFLVDRYKPGVSKV 508
                                               |.|:..:..|:..|...|
 Frog   422 -----------------------------------FWESTSVFPLSPLSPENF------------ 439

  Fly   509 VRFDAKEDYVMKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCKTENAEELLEAINLATK 573
                                                 |:...||
 Frog   440 -------------------------------------DQKTKET--------------------- 446

  Fly   574 GQDLPLAEAINMPLLQQGRRGRLDKSHSTPAYDNSGEESDTPPAIEPRKEFLLVTPPAPPPRPRK 638
             :.||:.||..:...|...|.|            ||.:|.|.|...|....|......|......
 Frog   447 -KALPITEADTLQNTQCMSRPR------------SGSDSFTTPTASPFSATLFAGLLRPALSDSN 498

  Fly   639 QREMTPPAVPPPPPKPASMQPASSITSISIPVPVPVPAAVDPSEISELHTPSKSRTLTLKKKHSL 703
            .:..|.|||.|.|..|..:...|             |:..|.:.:|:....:||..:|:.|.:|.
 Frog   499 LKASTDPAVLPQPNVPKEVTAKS-------------PSIKDDNLVSKSPQTAKSPQVTVTKTNSK 550

  Fly   704 MAK---------------------RRNTNLKLLGTGDIQGHLYRRKKNHRGVTY-WARIYFVMLD 746
            ..:                     ||..:.:.||..|..|.|.::|:|...:|. |.|.:.|:..
 Frog   551 QTQHGKEKSPGARRKKKGVATKLSRRRVSCRDLGNPDCDGWLTKKKENAGFMTQKWKRCWCVLKG 615

  Fly   747 TILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYH-TAKSFYFAAESLDALNQWVDFL 810
            ..||.:...|...|..::.:..:.:..|:| ..|.:.|::.| |.|.|.|||:||..|::||..|
 Frog   616 DRLYWYNVPQDEKALGLVNISSYKLESARE-PKKKYEFQLCHPTYKPFVFAADSLSDLSKWVTSL 679

  Fly   811 RQASLKVPPSTGSKGGGDAKDLYSENDSSGEECDALVIQN-LSTPSPQGNKESMSMSMTLSGGTP 874
             .|:|.:..:..|......:|.|||.::...:.|....|. :.||......:::|.|.|.|..:.
 Frog   680 -LAALNIHKTASSATQAHEEDCYSETEAEDLDEDHSKTQEVVKTPLTHVQSQNISSSPTTSEESN 743

  Fly   875 PSSAPIKHERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQYRSYRKVPGGSFGIQIGANT----- 934
            .|      |.|.:         .|.|..:|::|   ..|...|..:..|.|.   |||.|
 Frog   744 TS------ESGQI---------LKESDVQPAND---TLESLISCLQQGGVSL---IGAKTVLTRD 787

  Fly   935 ------------PGYHDPAMPPTQIPPLVGPKLSRSSSRSSVVSGTESAVSLSASI--------- 978
                        |..:..|.....:...:..||....:.:.::...    |||::|
 Frog   788 DYRKSFVRRNKNPEINQKAHALRALQSTLKAKLLELEALNQILENP----SLSSAIFQKWKSDHG 848

  Fly   979 -LGPPASPAPTPTPTATPTSLQHQSSEESPSQSQ 1011
             |.......|.|..|...|.....||.|...|::
 Frog   849 QLYETLGRGPKPRSTVVDTWAHTDSSGEEKEQAE 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	21/54 (39%)
		SAM	7..74	CDD:197735	21/54 (39%)
		CRIC_ras_sig	82..165	CDD:287501	22/88 (25%)
		PDZ_signaling	206..283	CDD:238492	29/78 (37%)
		PH	720..814	CDD:278594	29/95 (31%)
		PH_CNK_insect-like	720..810	CDD:270135	28/91 (31%)
cnksr1	XP_031751525.1	SAM_superfamily	<26..77	CDD:417767	21/52 (40%)
		CRIC_ras_sig	85..174	CDD:402249	23/90 (26%)
		PDZ	212..292	CDD:214570	29/79 (37%)
		PHA03247	<297..539	CDD:223021	69/421 (16%)
		PH_CNK_mammalian-like	574..687	CDD:269962	36/114 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9563
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3021
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1121556at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49316
Panther	1	1.100	-	-	LDO	PTHR12844
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.070