DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha5 and PUP2

DIOPT Version :9

Sequence 1:	NP_477202.2	Gene:	Prosalpha5 / 36951	FlyBaseID:	FBgn0016697	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_011769.1	Gene:	PUP2 / 853168	SGDID:	S000003485	Length:	260	Species:	Saccharomyces cerevisiae

Alignment Length:	244	Identity:	142/244 - (58%)
Similarity:	178/244 - (72%)	Gaps:	2/244 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGICTPEGVVLAVEKRITSPLMVPSTVE 65
            ||||||||||||:|||||||||||||::||||||||||||.|.|||||.||||.||||:...::|
Yeast     1 MFLTRSEYDRGVSTFSPEGRLFQVEYSLEAIKLGSTAIGIATKEGVVLGVEKRATSPLLESDSIE 65

  Fly    66 KIVEVDKHIGCATSGLMADARTLIERARVECQNHWFVYNERMSIESCAQAVSTLAIQFGDSGDSD 130
            ||||:|:|||||.|||.||||::||.||.....|...|:|.:::||..|:|..||::||: |.|.
Yeast    66 KIVEIDRHIGCAMSGLTADARSMIEHARTAAVTHNLYYDEDINVESLTQSVCDLALRFGE-GASG 129

  Fly   131 GAAAMSRPFGVAILFAGIEAGQP-QLWHMDPSGTFVRHGAKAIGSGSEGAQQNLQDLFRPDLTLD 194
            ....||||||||:|.||.:|... ||:|.:|||||.|:.||||||||||||..|.:.:...|||.
Yeast   130 EERLMSRPFGVALLIAGHDADDGYQLFHAEPSGTFYRYNAKAIGSGSEGAQAELLNEWHSSLTLK 194

  Fly   195 EAIDISLNTLKQVMEEKLNSTNVEVMTMTKEREFYMFTKEEVEQHIKNI 243
            ||..:.|..|||||||||:..|.::..:||:..|.::..|:..:.||.:
Yeast   195 EAELLVLKILKQVMEEKLDENNAQLSCITKQDGFKIYDNEKTAELIKEL 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha5	NP_477202.2	PRK03996	8..243	CDD:235192	135/235 (57%)
Prosalpha5	NP_477202.2	proteasome_alpha_type_5	8..222	CDD:239722	129/214 (60%)
PUP2	NP_011769.1	proteasome_alpha_type_5	8..222	CDD:239722	129/214 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342063
Domainoid	1	1.000	198	1.000	Domainoid score	I583
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2084
Inparanoid	1	1.050	263	1.000	Inparanoid score	I618
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54013
OrthoFinder	1	1.000	-	-		FOG0004131
OrthoInspector	1	1.000	-	-		oto99185
orthoMCL	1	0.900	-	-		OOG6_101621
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1007
SonicParanoid	1	1.000	-	-		X2875
TreeFam	1	0.960	-	-
	15	14.790