DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha5 and PSMB5

DIOPT Version :9

Sequence 1:	NP_477202.2	Gene:	Prosalpha5 / 36951	FlyBaseID:	FBgn0016697	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_002788.1	Gene:	PSMB5 / 5693	HGNCID:	9542	Length:	263	Species:	Homo sapiens

Alignment Length:	188	Identity:	45/188 - (23%)
Similarity:	89/188 - (47%)	Gaps:	23/188 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 EYAIEAIKLGSTAIGICTPEGVVLAVEKRITSPLMVPS-TVEKIVEVDKHIGCATSGLMADA--- 85
            |..||.:. |:|.:......||::|.:.|.|:...:.| ||:|::|::.::....:|..||.
Human    51 EPGIEMLH-GTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFW 114

  Fly    86 -RTLIERARV-ECQNHWFVYNERMSIESCAQAVSTLAIQFGDSGDSDGAAAMSRPFGVAILFAGI 148
             |.|..:.|: |.:|     .||:|:.:.::.::.:..|:...|.|.|.           :..|.
Human   115 ERLLARQCRIYELRN-----KERISVAAASKLLANMVYQYKGMGLSMGT-----------MICGW 163

  Fly   149 EAGQPQLWHMDPSGTFVRHGAKAIGSGSEGAQQNLQDLFRPDLTLDEAIDISLNTLKQ 206
            :...|.|:::|..|..:.....::||||..|...:...:..||.:::|.|::...:.|
Human   164 DKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQ 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha5	NP_477202.2	PRK03996	8..243	CDD:235192	45/188 (24%)
Prosalpha5	NP_477202.2	proteasome_alpha_type_5	8..222	CDD:239722	45/188 (24%)
PSMB5	NP_002788.1	proteasome_beta_type_5	60..247	CDD:239730	41/178 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810