DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha5 and pas-5

DIOPT Version :9

Sequence 1:	NP_477202.2	Gene:	Prosalpha5 / 36951	FlyBaseID:	FBgn0016697	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_492765.1	Gene:	pas-5 / 172942	WormBaseID:	WBGene00003926	Length:	248	Species:	Caenorhabditis elegans

Alignment Length:	251	Identity:	145/251 - (57%)
Similarity:	189/251 - (75%)	Gaps:	11/251 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGICTPEGVVLAVEKRITSPLMVPSTVE 65
            ||||||||||||||||||||||||||||||:|||||:|||.|.|||:||.|||.||.|||...:|
Worm     1 MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAVKLGSTSIGIKTSEGVLLAAEKRSTSKLMVNDAIE 65

  Fly    66 KIVEVDKHIGCATSGLMADARTLIERARVECQNHWFVYNERMSIESCAQAVSTLAIQFGDSGDSD 130
            ||.:||:|||...:||:||:|||:|||::|.||.||.||.::.:|...|:|:.||:||   ||.|
Worm    66 KISKVDQHIGVTFAGLIADSRTLVERAQIEAQNFWFTYNRKIRVEDVTQSVANLALQF---GDDD 127

  Fly   131 GAAAMSRPFGVAILFAGIEAGQPQLWHMDPSGTFVRHGAKAIGSGSEGAQQNLQDLFRPDLTLDE 195
            ..|:||||||||:||||::....:|:|:||||||:...||:||:.|:||:|||::.:...||:.|
Worm   128 VKASMSRPFGVAMLFAGVDQEGAKLFHLDPSGTFIDCKAKSIGAASDGAEQNLKEQYHDALTIKE 192

  Fly   196 AIDISLNTLKQVMEEKLNSTNVEVMTM-----TKER---EFYMFTKEEVEQHIKNI 243
            .:.::|..|||||||||||.||||:.:     .|.|   ||...:.||::|.|.::
Worm   193 GLKMALAILKQVMEEKLNSANVEVVVIKPTVDAKGRPIGEFTRVSNEELDQVITSL 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha5	NP_477202.2	PRK03996	8..243	CDD:235192	138/242 (57%)
Prosalpha5	NP_477202.2	proteasome_alpha_type_5	8..222	CDD:239722	130/213 (61%)
pas-5	NP_492765.1	PRK03996	8..248	CDD:235192	138/242 (57%)
pas-5	NP_492765.1	proteasome_alpha_type_5	8..219	CDD:239722	130/213 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157601
Domainoid	1	1.000	214	1.000	Domainoid score	I1590
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2084
Inparanoid	1	1.050	276	1.000	Inparanoid score	I1781
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54013
OrthoDB	1	1.010	-	-		D1222564at2759
OrthoFinder	1	1.000	-	-		FOG0004131
OrthoInspector	1	1.000	-	-		oto20543
orthoMCL	1	0.900	-	-		OOG6_101621
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1007
SonicParanoid	1	1.000	-	-		X2875
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840