DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbl and ZC3H10

DIOPT Version :9

Sequence 1:	NP_001261046.1	Gene:	mbl / 36945	FlyBaseID:	FBgn0265487	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001290053.1	Gene:	ZC3H10 / 84872	HGNCID:	25893	Length:	434	Species:	Homo sapiens

Alignment Length:	428	Identity:	86/428 - (20%)
Similarity:	141/428 - (32%)	Gaps:	150/428 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VCREFQRNKCSRQDTECKFAHPP----ANVEVQNGKVTACYDSIKGRCNRDKPPCKYFHPPQHLK 83
            :||:|.||.|.| ...|::.||.    :|:.|...:...|:|.....|:|  |.|::.|..:..:
Human    41 ICRDFLRNVCKR-GKRCRYRHPDMSEVSNLGVSKNEFIFCHDFQNKECSR--PNCRFIHGSKEDE 102

  Fly    84 DQLLINGRNHLALKNALMQQMGIAPGQPVISGQVPAVATNPYLTGIPANSYSPYYTTGHLVPALL 148
            |                                                   .|..||.|.|.|
Human   103 D---------------------------------------------------GYKKTGELPPRL- 115

  Fly   149 GPDPVTSQLGPVVPQTVQVAQQKIPRSDRLEVCREFLRGACKRAESECRFAHPQ---ESVARHDD 210
             ...|.:.|| :.|..:...::::|      :||:||:|.|:|. ::|:|.|.|   |..||...
Human   116 -RQKVAAGLG-LSPADLPNGKEEVP------ICRDFLKGDCQRG-AKCKFRHLQRDFEFDARGGG 171

  Fly   211 GSITVCMDAVKGRCARDPCRYFHPPLHLQAQLKAAQTRATAVAAAAAVW------LYTIYFSILF 269
            |                                      |...:..:|.      ||.||
Human   172 G--------------------------------------TGGGSTGSVLPGRRHDLYDIY----- 193

  Fly   270 EPSLCMDVKTVGSFYYDNFQFSGMVPFKRPAAEKSG-IPVYQPGATAYQQLMQPYVPVSCEYPQQ 333
                  |:...|        |....|  .|...:.| .|...|...:|:..:.|...|.|...::
Human   194 ------DLPDRG--------FEDHEP--GPKRRRGGCCPPDGPHFESYEYSLAPPRGVECRLLEE 242

  Fly   334 QQQPPPQQQQQQQHQQQN------VLLQQQLQL--SSVITTTSTTATASNNMINNNINNKGIINA 390
            :.....::.::.:.|..|      |||:|..|.  .:.:.|.|:||.|:...:...:......|.
Human   243 ENAMLRKRVEELKKQVSNLLATNEVLLEQNAQFRNQAKVITLSSTAPATEQTLAPTVGTVATFNH 307

  Fly   391 VMASTNITSSATT-----TASSSLLSALGTPPTTTTTA 423
            .:|.|:.|.|:..     .:...|::..|.|....|.|
Human   308 GIAQTHTTLSSQALQPRPVSQQELVAPAGAPAAPPTNA 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbl	NP_001261046.1	ZnF_C3H1	175..201	CDD:214632	9/25 (36%)
ZC3H10	NP_001290053.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		ZnF_C3H1	40..62	CDD:214632	9/21 (43%)
		ZnF_C3H1	134..158	CDD:214632	10/30 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..217		5/30 (17%)
		SPATA1_C	236..>293	CDD:292371	13/56 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..362		7/32 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770