DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbl and Zc3h10

DIOPT Version :9

Sequence 1:	NP_001261046.1	Gene:	mbl / 36945	FlyBaseID:	FBgn0265487	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_598764.1	Gene:	Zc3h10 / 103284	MGIID:	2143670	Length:	435	Species:	Mus musculus

Alignment Length:	422	Identity:	87/422 - (20%)
Similarity:	141/422 - (33%)	Gaps:	137/422 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VCREFQRNKCSRQDTECKFAHPP----ANVEVQNGKVTACYDSIKGRCNRDKPPCKYFHPPQHLK 83
            :||:|.||.|.| ...|::.||.    :|:.|...:...|:|.....|:|  |.|::.|..:..:
Mouse    41 ICRDFLRNVCKR-GKRCRYRHPDMSEVSNLGVSKNEFIFCHDFQNKECSR--PNCRFIHGSKEDE 102

  Fly    84 DQLLINGRNHLALKNALMQQMGIAPGQPVISGQVPAVATNPYLTGIPANSYSPYYTTGHLVPALL 148
            |                                                   .|..||.|.|.|
Mouse   103 D---------------------------------------------------GYKKTGELPPRL- 115

  Fly   149 GPDPVTSQLGPVVPQTVQVAQQKIPRSDRLEVCREFLRGACKRAESECRFAHPQ---ESVARHDD 210
             ...|.:.|| :.|..:...::::|      :||:||:|.|:|. ::|:|.|.|   |..||...
Mouse   116 -RQKVAAGLG-LSPADLPNGKEEVP------ICRDFLKGDCQRG-AKCKFRHLQRDFEFDARGGG 171

  Fly   211 GSITVCMDAVKGRCARDPCRYFHPPLHLQAQLKAAQTRATAVAAAAAVWLYTIYFSILFEPSLCM 275
            |:      ...|.....|....|.                         ||.||
Mouse   172 GT------GGGGSTGSAPPGRRHD-------------------------LYDIY----------- 194

  Fly   276 DVKTVGSFYYDNFQFSGMVPFKRPAAEKSG-IPVYQPGATAYQQLMQPYVPVSCEYPQQQQQPPP 339
            |:...|        |....|  .|...:.| .|...|...:|:..:.|...|.|...:::.....
Mouse   195 DLPERG--------FEDHEP--GPKRRRGGCCPPDGPHFESYECNLAPLRGVECRLLEEENALLR 249

  Fly   340 QQQQQQQHQQQN------VLLQQQLQL--SSVITTTSTTATASNNMINNNINNKGIINAVMASTN 396
            ::.::.:.|..|      |||:|..|.  .:.:.|.|:||.|:...:...:......|..:|.|:
Mouse   250 KRVEELKKQVSNLLATNEVLLEQNAQFRNQAKVMTLSSTAPATEQTLAPTVGTVATFNHGIAQTH 314

  Fly   397 ITSSATT-----TASSSLLSALGTPPTTTTTA 423
            .|.|:..     .:...|::..|.|....|.|
Mouse   315 TTLSSQALQPRPVSQQELVAPTGAPAAPPTNA 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbl	NP_001261046.1	ZnF_C3H1	175..201	CDD:214632	9/25 (36%)
Zc3h10	NP_598764.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		ZnF_C3H1	40..62	CDD:214632	9/21 (43%)
		ZnF_C3H1	134..158	CDD:214632	10/30 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..190		6/54 (11%)
		ZapB	<243..>279	CDD:368701	7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..363		7/32 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770