DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbl and MBNL2

DIOPT Version :9

Sequence 1:	NP_001261046.1	Gene:	mbl / 36945	FlyBaseID:	FBgn0265487	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001369612.1	Gene:	MBNL2 / 10150	HGNCID:	16746	Length:	391	Species:	Homo sapiens

Alignment Length:	404	Identity:	156/404 - (38%)
Similarity:	206/404 - (50%)	Gaps:	90/404 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KDSRWLQLEVCREFQRNKCSRQDTECKFAHPPANVEVQNGKVTACYDSIKGRCNRDKPPCKYFHP 78
            :|::||.|||||:|||..|||.|.||||||||.:.:|:||:|.||:||:||||:|:.  |||.||
Human     9 RDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSREN--CKYLHP 71

  Fly    79 PQHLKDQLLINGRNHLALKNA----LMQQMG-IAPGQPVISGQVPAVATNPYLTGIPANSYSPYY 138
            |.|||.||.|||||:|..:..    |.|||. :.||.|:  ..||.....|.:....|.|::||
Human    72 PTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPL--HPVPTFPVGPAIGTNTAISFAPY- 133

  Fly   139 TTGHLVPALLGPDPVTSQLGPVVPQTV----------QVAQQKIPRSDRLEVCREFLRGACKRAE 193
                |.|...|...|.:::.|..|..|          ..|.||:.|:|:|||||||.||.|.|.|
Human   134 ----LAPVTPGVGLVPTEILPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGE 194

  Fly   194 SECRFAHPQES-VARHDDGSITVCMDAVKGRCARDPCRYFHPPLHLQAQLKAAQTRA--TAVAAA 255
            ::||||||.:| :....|.::|||||.:||||.|:.|:|||||.||||::||||.:|  .||||.
Human   195 TDCRFAHPADSTMIDTSDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQ 259

  Fly   256 AAVWLYTIY---------------FSILFEPSLCMDVKTVGSFYYDNFQFSGMVPF-KRPAAEKS 304
            ||....|:.               ..:.|.|         |:.:          |. ||.|.|||
Human   260 AAAAAATVMTQSTAKAMKRPLEATVDLAFPP---------GALH----------PLPKRQALEKS 305

  Fly   305 G--IPVYQPGATAYQQLMQPYVPVSCEYPQQQQQPPPQQQQQQQHQQQNVLLQQQLQLSSVITTT 367
            .  ..|:.|....|||.:                   ...|.|||       ...:...||:..|
Human   306 NGTSAVFNPSVLHYQQAL-------------------TSAQLQQH-------AAFIPTGSVLCMT 344

  Fly   368 STTATASNNMINNN 381
            ..|:..::.:|:.|
Human   345 PATSIDNSEIISRN 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbl	NP_001261046.1	ZnF_C3H1	175..201	CDD:214632	17/25 (68%)
MBNL2	NP_001369612.1	ZnF_C3H1	17..40	CDD:214632	17/22 (77%)
MBNL2	NP_001369612.1	ZnF_C3H1	178..202	CDD:214632	16/23 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147526
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4330
Isobase	1	0.950	-	0	Normalized mean entropy	S5175
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001679
OrthoInspector	1	1.000	-	-		otm40923
orthoMCL	1	0.900	-	-		OOG6_109473
Panther	1	1.100	-	-	LDO	PTHR12675
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2627
SonicParanoid	1	1.000	-	-		X1238
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.730