Protein Alignment CG10950 and TNPO3

DIOPT Version :9

• Sequence 1: NP_611200.2
• Gene: CG10950 / 36942
• FlyBaseID: FBgn0034205
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001369145.1
• Gene: TNPO3 / 23534
• HGNCID: 17103
• Length: 957
• Species: Homo sapiens
• Alignment Length: 642
• Identity: 164/642 - (25%)
• Similarity: 277/642 - (43%)
• Gaps: 101/642 - (15%)

  Fly     3 AEFTKELVIDAVNML-----SSGNISLANEYLAAFQKSNDTWIIAEEILSYRPPHDMHILTFAAM 62
            |:.|.:||..||..|     .||. ..|:.:|...|:|...|.|::::|..|  .|:....|||.
Human     4 AKPTLQLVYQAVQALYHDPDPSGK-ERASFWLGELQRSVHAWEISDQLLQIR--QDVESCYFAAQ 65

  Fly    63 SLAKKIKTSFYSLQKFQLMSLKNSLIDHLKYAAMMRDSNSLIV-QLAVGISALGLMFSQWDYELQ 126
            ::..||:||||.|......||::||:.|::   .::|.:.:|| |||:.|:.|.|....|...:|
Human    66 TMKMKIQTSFYELPTDSHASLRDSLLTHIQ---NLKDLSPVIVTQLALAIADLALQMPSWKGCVQ 127

  Fly   127 DFVRKLSENPQYVMALLEVLKVIPEETRPSNLPVEAKKLNSVIDTLEQQSPYILDVLEGLLQRPD 191
            ..|.|.|.:...:..|||:|.|:|||....:|.:.|.:...:|:.|...|..::.:|...:::..
Human   128 TLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAG 192

  Fly   192 LPDDALPKCLAVCASWTKFSMLSPDQVLQRKLFIMAEFILATPLVNGHL-EAAELFVALLEQSLI 255
            ..:..|.|......||....:|..:.:...||..:...:|.....:.:| |||...|.....::.
Human   193 TDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIE 257

  Fly   256 RKELNSCLA----NSVICLKPAFKRSMGERSL--LQNYCNIFVNLFQTHFRLTQTNPERLNERLV 314
            ..|.|..||    ..|:.|:.|:..::....|  :.|||.||..|.:|........|.:....|.
Human   258 NVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLR 322

  Fly   315 TIELLLLVAEESPLEVIEASLGMWSSISEEVYLHDDPEMYSVYQPYFVRLLDLLLPRAALPANYE 379
            |:||||:.|.....||:|.|...|..:.|.:|..:|..::.:::.|..|||..|.....|..::|
Human   323 TLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHE 387

  Fly   380 FMMPPGSADMQRFRELIGEVLLDMAHMIDD-DTVEKLCSIVVDEQSPWMEVEASVFFL------- 436
             .:|..:.|...||..:.:::.|:..:|.. :...:|.|.:.:...||...||.:|.:
Human   388 -GVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSV 451

  Fly   437 -----------RHLIGNFKEHQTDIISCILKTFFQKDCQ--QPFIR------LQVLE-LISIPEI 481
                       ||.: .|.::.|..||         :|:  .|.:|      ::||| ::.:||.
Human   452 DPKKPFSNAVCRHSL-LFGQNITSEIS---------NCEYLPPVLRENNPTLVEVLEGVVRLPET 506

  Fly   482 V-------SVETIWDCLVNELRRA--------DPML-----------------SAID-----CRL 509
            |       |:|     ||.|:...        ||:|                 .||.     ||
Human   507 VHTAVRYTSIE-----LVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCR- 565

  Fly   510 NLLMPHWNYLVTLAIMVDEFCLKESERCELLCSICTLIRELPAACVQEAKTSILNIR 566
            :.:..|:|.|:.:|..:|.|.|.......||.....::..||...:.|..:.:.:::
Human   566 DHMAQHFNGLLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQ 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10950	NP_611200.2	IBN_N	25..91	CDD:197981	23/65 (35%)
		Xpo1	103..>207	CDD:285575	29/104 (28%)
TNPO3	NP_001369145.1	IBN_N	33..96	CDD:197981	23/67 (34%)
		Xpo1	121..248	CDD:400614	31/126 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2081
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12363
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910