DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10950 and T16G12.6

DIOPT Version :9

Sequence 1:	NP_611200.2	Gene:	CG10950 / 36942	FlyBaseID:	FBgn0034205	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001366683.1	Gene:	T16G12.6 / 176420	WormBaseID:	WBGene00011807	Length:	949	Species:	Caenorhabditis elegans

Alignment Length:	515	Identity:	103/515 - (20%)
Similarity:	198/515 - (38%)	Gaps:	112/515 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 MSLKNSLIDHLKYAAMMRDSNSLIVQLAVGISALGL--MFSQWDYELQDFVRKLSENPQYVMALL 143
            :|||..|||.||..|..: :.|::.:|:..::...|  :...|...:||....|:.:|:   .||
Worm    90 LSLKTFLIDSLKSGAYAQ-TTSVLNKLSAALALFSLYCVPDLWPTPVQDLTPTLAGSPE---ILL 150

  Fly   144 EVLKVIPEETRPSNLPV-EAKKLNSVIDTLEQQSPYILDVLEGLLQRPD---LPDDALPKCLAVC 204
            :||..:..|.....:|: :..||..   .|.:.|..|:.||..:|:..|   :...|..:|:
Worm   151 KVLSDMAAEFSHVTMPLTQRSKLKG---ELHKFSENIISVLAVVLRGGDTSSITKQAAVECV--- 209

  Fly   205 ASWTKFSMLSPDQVLQRKLFIMAEFILATPLVNGHLEAAELFVALLEQSLIRKELNSCLANSV-- 267
            ..|.:.    |...|.:...::::.:.|  :|......|.:...:.|.....:  ||.|..|:
Worm   210 EQWLRL----PGMALDQWTHVLSDVLGA--VVQDCTALASILDIIAENDEFHR--NSTLIISICQ 266

  Fly   268 -ICLKPAFK--RSMGE-------RSLLQNYCNIFVNLFQTHFRLTQTNPERLNERLV-----TIE 317
             ||...:.|  ..:|.       .:|:...|::..|...|   |.:...:..:..||     .::
Worm   267 YICFNVSGKIEEELGADASSEEIATLVAATCSVSENSVPT---LVECAAQGGDSELVIRLSQVMQ 328

  Fly   318 LLLLVAEESPLEVIEASL----------GMWSSISEEVYLHDDPEMYSVYQPYFVRLLDLLLPRA 372
            :|..:..:.|||.|.:.|          .:..:|:..:.:  |.::.|.....:.::|::.:.:.
Worm   329 VLANMQGQYPLEEIVSDLPSIYFITLRTEIMQTINSGIQI--DKQILSQIGQIYAKILEMSIKKL 391

  Fly   373 ALPANYEFMMPPGSADMQRF---RELIGEVLLDMAHMIDDDTVEKLCSIVVDEQSPWMEVEASVF 434
            |.|:. |..:.....:.::|   |:...|...|..|.....|::.|      .|:
Worm   392 AFPSK-EIWLSWNLEEREQFESYRKTRSEASYDSYHFSAAGTLDFL------NQT---------- 439

  Fly   435 FLRHLIGNFKEHQTDIISCILKTFFQKDCQQPFIR-------LQVLELISIPEIVSVETIWDCLV 492
             |...:|....::|:  |||    ||.:|...::.       |:.||:              |..
Worm   440 -LEQALGAGDVNRTE--SCI----FQWECVADYLGETDYTAILKCLEM--------------CAS 483

  Fly   493 NELRRADPMLSA-----IDCRLNLLMPHWNYLVTLAIMVDEFCLKESERCELLCSICTLI 547
            ::|....|..|:     ||..||   .....|:.|...:.....:..:..||.|::..:|
Worm   484 SQLSAPPPSTSSSSSDKIDIDLN---RRGETLMRLFYSLSHLIQEHEQAKELECALIPII 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10950	NP_611200.2	IBN_N	25..91	CDD:197981	6/9 (67%)
CG10950	NP_611200.2	Xpo1	103..>207	CDD:285575	24/109 (22%)
T16G12.6	NP_001366683.1	Xpo1	111..>214	CDD:400614	25/111 (23%)
T16G12.6	NP_001366683.1	Importin_rep	393..>414	CDD:408544	3/21 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004114
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910