DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17287 and Zdhhc2

DIOPT Version :9

Sequence 1:	NP_611197.1	Gene:	CG17287 / 36939	FlyBaseID:	FBgn0034202	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_848482.1	Gene:	Zdhhc2 / 70546	MGIID:	1923452	Length:	366	Species:	Mus musculus

Alignment Length:	303	Identity:	117/303 - (38%)
Similarity:	169/303 - (55%)	Gaps:	19/303 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCPIGEGHRRVPCCAV-RWLPALIILGFLVWSYHVFVYQICIKKVSDYLTIGLLLFFYHLLLFMF 64
            |.|.|.|..|..|..| .|:|.:.|...|.|||:.:..|:||..:.:.....:.|..||||..||
Mouse     1 MAPSGSGGVRRRCRRVLYWIPVVFISLLLGWSYYAYAIQLCIVSMENIGEQVVCLMAYHLLFAMF 65

  Fly    65 LWTWFRCIFVAPVRIPDQWKISPEDVDKLKRNDGIEGASRVLNYAARNLPIATCTIDGLVRYCKT 129
            :|::::.||..|:....::.:|..:.:.|:|....|....||..||::|||.|.|:.|.:|||..
Mouse    66 VWSYWKTIFTLPMNPSKEFHLSYAEKELLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAIRYCDR 130

  Fly   130 CWIIKPDRAHHCRTCHMCVLKMDHHCPWIVNCVHFHNFKYFILFLFYAEVYCFYLFCVMVYDLYL 194
            |.:|||||.|||..|..|:|||||||||:.|||.|.|:|:|:|||.|:.:||.:   :...||..
Mouse   131 CQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCLF---IAATDLQY 192

  Fly   195 ICGFEVTALKNQHSWNILQYLVCILFNIFTVIMYTVSLLN--------VSRNRTTMESAYATYFL 251
            ...|....|.:      .|....|:|..|...|::|||.:        ||:|::|:| |:.....
Mouse   193 FIRFWTNGLPD------TQAKFHIMFLFFAAAMFSVSLSSLFGYHCWLVSKNKSTLE-AFRNPVF 250

  Fly   252 LGGKNNNGFNLGYFVNFRDLYGDKWYLWPFPIFSSRGDGFSFP 294
            ..|.:.|||:||:..|.|.::||:...|..|:|||:|||.|||
Mouse   251 RHGTDKNGFSLGFSKNMRQVFGDEKKYWLLPVFSSQGDGCSFP 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17287	NP_611197.1	zf-DHHC	125..243	CDD:279823	52/125 (42%)
Zdhhc2	NP_848482.1	DHHC	126..247	CDD:366691	54/130 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..366
		Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000269\|PubMed:21471008	298..366
		Non-canonical dileucine endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	334..335
		NPxY-like endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	357..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848307
Domainoid	1	1.000	52	1.000	Domainoid score	I11381
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1491968at2759
OrthoFinder	1	1.000	-	-		FOG0000300
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100499
Panther	1	1.100	-	-	O	PTHR22883
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1716
SonicParanoid	1	1.000	-	-		X260
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.740