DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17287 and ZDHHC13

DIOPT Version :9

Sequence 1:	NP_611197.1	Gene:	CG17287 / 36939	FlyBaseID:	FBgn0034202	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_061901.2	Gene:	ZDHHC13 / 54503	HGNCID:	18413	Length:	622	Species:	Homo sapiens

Alignment Length:	341	Identity:	68/341 - (19%)
Similarity:	114/341 - (33%)	Gaps:	131/341 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 WLPALIILG-----FLVW------------SYHVFVYQICIKKVSDYLTIGLLLFFYHLLLFMFL 65
            :||...:|.     |:.|            .|..|::.|          :..|.|||.
Human   346 YLPTAFLLSSVFWIFMTWFILFFPDLAGAPFYFSFIFSI----------VAFLYFFYK------- 393

  Fly    66 WTWFRCIFVAPVRIPDQWKISPEDVDKLKRNDGIEGASRVLNYAARNLPIATCTIDGLV---RYC 127
             ||        ...|...|.|.|:                     :.:.|.|....|.:   .:|
Human   394 -TW--------ATDPGFTKASEEE---------------------KKVNIITLAETGSLDFRTFC 428

  Fly   128 KTCWIIKPDRAHHCRTCHMCVLKMDHHCPWIVNCVHFHNFKYFILFLFYAEVYCFYLFCVMVYDL 192
            .:|.|.||.|:.||..|:.||.:.|.||.|...|:.|.|..|:|.|||:..:.|.::    :|..
Human   429 TSCLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWI----IYGS 489

  Fly   193 YL-ICGFEVTALKNQHSWNIL-QYLVCILFNIFTVIMYTVSLLNVSRNRTTMESAYATYFLLGGK 255
            :: :.....|..|....|..| |.:.|..:     ::|.:.|       .|...:::|:.||
Human   490 FIYLSSHCATTFKEDGLWTYLNQIVACSPW-----VLYILML-------ATFHFSWSTFLLL--- 539

  Fly   256 NNNGFNLGYFVNFRDLYGDKWYLWPFPIFSSRGDGFSFPLAHDRLKEVRTGNQKKDNQPTRTQMY 320
             |..|.:.:.                        |.:   :|:|:.               .|..
Human   540 -NQLFQIAFL------------------------GLT---SHERIS---------------LQKQ 561

  Fly   321 KENMNRILGIHQPPFN 336
            .::|.:.|.:.:.|:|
Human   562 SKHMKQTLSLRKTPYN 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17287	NP_611197.1	zf-DHHC	125..243	CDD:279823	34/119 (29%)
ZDHHC13	NP_061901.2	ANK 1. /evidence=ECO:0000250\|UniProtKB:Q8IUH5	43..78
		ANK	79..192	CDD:238125
		ANK repeat	81..112	CDD:293786
		ANK 2. /evidence=ECO:0000255	81..110
		ANK repeat	114..146	CDD:293786
		ANK 3. /evidence=ECO:0000255	115..144
		ANKYR	<145..271	CDD:223738
		ANK repeat	148..179	CDD:293786
		ANK 4. /evidence=ECO:0000255	148..177
		ANK repeat	181..247	CDD:293786
		ANK 5. /evidence=ECO:0000255	181..211
		ANK 6. /evidence=ECO:0000255	216..245
		ANK 7. /evidence=ECO:0000255	249..277
		zf-DHHC	423..559	CDD:307600	42/197 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810