DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17287 and ZDHHC15

DIOPT Version :9

Sequence 1:	NP_611197.1	Gene:	CG17287 / 36939	FlyBaseID:	FBgn0034202	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_659406.1	Gene:	ZDHHC15 / 158866	HGNCID:	20342	Length:	337	Species:	Homo sapiens

Alignment Length:	314	Identity:	109/314 - (34%)
Similarity:	179/314 - (57%)	Gaps:	14/314 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CC--AVRWLPALIILGFLVWSYHVFVYQICIKKVSDYLTIGLLLFFYHLLLFMFLWTWFRCIFVA 75
            ||  .:.|:|.|:|:..::|||:.:|:::|:..|.......:.|..||.:...|.||:::.||..
Human    15 CCRRVLSWVPVLVIVLVVLWSYYAYVFELCLVTVLSPAEKVIYLILYHAIFVFFTWTYWKSIFTL 79

  Fly    76 PVRIPDQWKISPEDVDKLKRNDGIEGASRVLNYAARNLPIATCTIDGLVRYCKTCWIIKPDRAHH 140
            |.:...::.:|..|.::.:..:..|...::|...|:.||:.|.|..|.||:|..|.:|||||.||
Human    80 PQQPNQKFHLSYTDKERYENEERPEVQKQMLVDMAKKLPVYTRTGSGAVRFCDRCHLIKPDRCHH 144

  Fly   141 CRTCHMCVLKMDHHCPWIVNCVHFHNFKYFILFLFYAEVYCFYLFCVMVYDLYL-ICGFEVTALK 204
            |..|.||||||||||||:.||:.|.|:|:|:.||.|:.:||.|: ...|:..:: ....|:.:::
Human   145 CSVCAMCVLKMDHHCPWVNNCIGFSNYKFFLQFLAYSVLYCLYI-ATTVFSYFIKYWRGELPSVR 208

  Fly   205 NQHSWNILQYLVCILFNIFTVIMYTVSLLNVSRNRTTMESAYATYFLLGGKNNNGFNLGYFVNFR 269
            ::.....|.::.|:.| :..||::......||||:||:| |:.|.....|...||||||:..|.:
Human   209 SKFHVLFLLFVACMFF-VSLVILFGYHCWLVSRNKTTLE-AFCTPVFTSGPEKNGFNLGFIKNIQ 271

  Fly   270 DLYGDKWYLWPFPIFSSRGDGFSFPLAHDRLKEVRTGNQKKDNQPTRTQMYKEN 323
            .::|||...|..||.||.|||.|||:        |:.|:.::......:.:::|
Human   272 QVFGDKKKFWLIPIGSSPGDGHSFPM--------RSMNESQNPLLANEETWEDN 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17287	NP_611197.1	zf-DHHC	125..243	CDD:279823	49/118 (42%)
ZDHHC15	NP_659406.1	zf-DHHC	<126..308	CDD:327686	78/192 (41%)
ZDHHC15	NP_659406.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..337		1/12 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157930
Domainoid	1	1.000	53	1.000	Domainoid score	I11356
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2012
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1491968at2759
OrthoFinder	1	1.000	-	-		FOG0000300
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100499
Panther	1	1.100	-	-	O	PTHR22883
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1716
SonicParanoid	1	1.000	-	-		X260
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.690