DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cda9 and lgx-1

DIOPT Version :9

Sequence 1:	NP_001286519.1	Gene:	Cda9 / 36934	FlyBaseID:	FBgn0034197	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001360720.1	Gene:	lgx-1 / 180825	WormBaseID:	WBGene00002983	Length:	1754	Species:	Caenorhabditis elegans

Alignment Length:	413	Identity:	131/413 - (31%)
Similarity:	207/413 - (50%)	Gaps:	72/413 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SKKQKNKQNGILPMAEPCKPSKCKLPDCRCSDAALPTSKFQG--KENQIPQFVTITFDDAVNAVN 87
            |.:..|:|.     |:.|..::||||:|.|::..   .:..|  :.::.||||.:|||||||...
Worm  1368 SMQVPNRQR-----AQACNEAECKLPNCFCTENG---RRAPGGLRPDETPQFVVLTFDDAVNGKT 1424

  Fly    88 FAQYELLF--DGLINPDGCGAAGTFFLSHEYTDYVRVNALYRAGHEIALHSVTH----GDGTDYW 146
            |:.|:.||  |.|.||:||....|||:|||:|:|..||.|.:...|||.:|::|    ...|:.|
Worm  1425 FSDYKKLFENDVLKNPNGCDVKATFFISHEWTNYDAVNWLVQKNMEIASNSISHESLENANTNRW 1489

  Fly   147 RSADVPTIEREFGAQLKMLETFAKVNPKKIQGMRLPFLQISGNNTFEAARRLGLTYDSSWPTQKF 211
            .:        |...|.::|..|.....::|.|:|.|.|.:.|:|.||  ..:|..:  .|.....
Worm  1490 LN--------EMDGQRRILAKFGGAPEEEIVGIRSPQLALGGDNQFE--MMIGAEF--LWDNSMS 1542

  Fly   212 KDPAM-----WPYTLDYKSKQDCQIGPCPEASIPGFWVNPM-------VTWTDTEGYSCSMIDAC 264
            .:|.:     ||.|:||:...||....||::|.||.|..|:       ::..|:...| ||:.|.
Worm  1543 ANPGIHGEPFWPQTMDYQVAWDCNEASCPKSSFPGVWSVPLNQFYGSYMSQIDSFRRS-SMLRAA 1606

  Fly   265 VYPPEDDMDELFDWMMENFNRHYLGNRAPFGMYLHAAWFSRGRNYFG--AFKKFINHLNTYSDVY 327
            | ...:.:|||.:.:..||.|.|..||||:.:.|:|.:...|.:..|  |.:||:|.::...|||
Worm  1607 V-DLNNTVDELEEIITRNFERSYSANRAPYVLSLNADFLQLGGHNKGMKAVQKFLNRMSAQKDVY 1670

  Fly   328 FTGISRMLEYVRKPTLGSPFKD-----CP--------------DLPEAECRAVQC--HVQKMSTG 371
            ...|.::::::::|...|..|.     ||              |:|.      :|  ....:|:.
Worm  1671 IVTIKQLIDWMKRPVPISEMKSSKAVGCPITLSFNRNPSLSTCDIPN------KCLYSTPSLSSQ 1729

  Fly   372 EERYMTVCDKCPSVYPWLDNPLG 394
            |.:::| |..||::||||:||.|
Worm  1730 EHQFLT-CLPCPTMYPWLENPAG 1751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cda9	NP_001286519.1	CE4_CDA_like_2	72..341	CDD:200597	98/288 (34%)
lgx-1	NP_001360720.1	EB	322..382	CDD:366756
		PHA02682	<388..>493	CDD:177464
		EB	565..620	CDD:366756
		EB	609..666	CDD:366756
		EB	<718..757	CDD:366756
		EB	911..967	CDD:366756
		EB	956..1020	CDD:366756
		EB	1009..1083	CDD:366756
		EB	1072..1124	CDD:366756
		EB	<1215..1253	CDD:366756
		EB	1242..1301	CDD:366756
		EB	1290..1346	CDD:366756
		CE4_CDA_like_1	1409..1684	CDD:200596	98/288 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003270
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010