DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amy-d and IMA4

DIOPT Version :9

Sequence 1:	NP_523768.1	Gene:	Amy-d / 36932	FlyBaseID:	FBgn0000078	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_012314.1	Gene:	IMA4 / 853235	SGDID:	S000003757	Length:	589	Species:	Saccharomyces cerevisiae

Alignment Length:	360	Identity:	79/360 - (21%)
Similarity:	126/360 - (35%)	Gaps:	113/360 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 WDD---IAAECENFLGPNGYAGVQVSPVNENAVKDSRPWWERYQPISYK--LETRSGNEEQFASM 98
            |.|   ||::.| ::...|...:.:||..::...|.     .|...:|:  ..|...||:.|| :
Yeast    36 WGDMKGIASKLE-YIKELGTDAIWISPFYDSPQDDM-----GYDIANYEKVWPTYGTNEDCFA-L 93

  Fly    99 VKRCNAVGVRTYVDVVFNHMAAD-------------------------GGTYGTGGSTASPSS-K 137
            :::.:.:|::...|:|.||.:::                         |  |...|....|:: :
Yeast    94 IEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKG--YDAEGKPIPPNNWR 156

  Fly   138 SYPGVPYSSLD-----FNPTCAISNYNDAN-EVRNCELVGLRDLNQGNSYVQDKVVEFLDHLIDL 196
            ||.|....:.|     |......|...|.| |..:|.          .:..:..|..:|||
Yeast   157 SYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCR----------KAIYESAVGYWLDH---- 207

  Fly   197 GVAGFRVDA----AKHMWPADLAVIYGRLKNLNTD---------HGFASGSKAYIVQEVIDMGGE 248
            ||.|||:|.    :|.....|..||....|...:|         |.|......:|...|.| |.|
Yeast   208 GVDGFRIDVGSLYSKVAGLPDAPVIDENSKWQLSDPFTMNGPRIHEFHQEMNKFIRNRVKD-GRE 271

  Fly   249 AISKSE-----------YTG-----LGAITEFRHSD-SIGKVFRGKDQLQY-LTNWGTA------ 289
            .::..|           ||.     |..:..|.|:| .....|| ::.:.| |.:|..|
Yeast   272 IMTVGEMRHATDETKRLYTSASRHELSELFNFSHTDVGTSPKFR-QNLIPYELKDWKVALAELFR 335

  Fly   290 -------WGFAASDRSLVFVDNHDNQRGHGAGGAD 317
                   |       |.::::|||..|.....|.|
Yeast   336 YVNGTDCW-------STIYLENHDQPRSITRFGDD 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amy-d	NP_523768.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	79/360 (22%)
		Alpha-amylase	54..342	CDD:278554	74/342 (22%)
		Aamy_C	405..493	CDD:214749
IMA4	NP_012314.1	AmyAc_SI_OligoGlu_DGase	16..503	CDD:200472	79/360 (22%)
IMA4	NP_012314.1	Malt_amylase_C	514..585	CDD:406946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342124
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830