DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amy-d and Amy2a3

DIOPT Version :9

Sequence 1:	NP_523768.1	Gene:	Amy-d / 36932	FlyBaseID:	FBgn0000078	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_113690.2	Gene:	Amy2a3 / 497039	RGDID:	1593187	Length:	508	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	282/510 - (55%)
Similarity:	355/510 - (69%)	Gaps:	23/510 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KSIVCLSLLAVANAQFDTNYASGRSGMVHLFEWKWDDIAAECENFLGPNGYAGVQVSPVNENAV- 68
            |.::.|||:....||:|.:.|.||:.:||||||:|.|||.|||.:|.|.|:.||||||.|||.:
  Rat     2 KFVLLLSLIGFCWAQYDPHTADGRTAIVHLFEWRWADIAKECERYLAPKGFGGVQVSPPNENIII 66

  Fly    69 -KDSRPWWERYQPISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHMAADG---GTYGTGG 129
             ..||||||||||||||:.:|||||.:|..||.|||.||||.|||.|.|||...|   ||:.|.|
  Rat    67 NNPSRPWWERYQPISYKICSRSGNENEFKDMVTRCNNVGVRIYVDAVINHMCGSGNSAGTHSTCG 131

  Fly   130 STASPSSKSYPGVPYSSLDFNPT-C--AISNYNDANEVRNCELVGLRDLNQGNSYVQDKVVEFLD 191
            |..:|:::.:..||||:.|||.. |  .|:||||||:||||.|.||.||.....||:.||.::::
  Rat   132 SYFNPNNREFSAVPYSAWDFNDNKCNGEINNYNDANQVRNCRLSGLLDLALDKDYVRTKVADYMN 196

  Fly   192 HLIDLGVAGFRVDAAKHMWPADLAVIYGRLKNLNTDHGFASGSKAYIVQEVIDMGGEAISKSEYT 256
            :|||:||||||:||||||||.|:..:..:|.|||| ..|:.||:.:|.|||||:|||||..|||.
  Rat   197 NLIDIGVAGFRLDAAKHMWPGDIKAVLDKLHNLNT-KWFSQGSRPFIFQEVIDLGGEAIKGSEYF 260

  Fly   257 GLGAITEFRHSDSIGKVFR--GKDQLQYLTNWGTAWGFAASDRSLVFVDNHDNQRGHGAGGADVL 319
            |.|.:|||::...:|.|.|  ..:::.||.|||..|||..:||:||||||||||||||||||.:|
  Rat   261 GNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFVPTDRALVFVDNHDNQRGHGAGGASIL 325

  Fly   320 TYKVPKQYKMASAFMLAHPFGTPRVMSSFSFTDTDQ---------GPPTTDGHNIASPI-FNSDN 374
            |:...:.||||..||||||:|..|||||:.:....|         |||..:|  :...: .|.|.
  Rat   326 TFWDARMYKMAVGFMLAHPYGFTRVMSSYRWARNFQNGKDVNDWIGPPNNNG--VTKEVTINPDT 388

  Fly   375 SCSGGWVCEHRWRQIYNMVAFRNAVGLDEIQNWWDSGSNQISFSRGSRGFVAFNNDNYDLNSSLQ 439
            :|...||||||||||.|||||||.|......||||:||||::||||:|||:.||||::.|:|:||
  Rat   389 TCGNDWVCEHRWRQIRNMVAFRNVVNGQPFANWWDNGSNQVAFSRGNRGFIVFNNDDWALSSTLQ 453

  Fly   440 TGLPAGTYCDVISGSKSGSSCTGKTVTVGSDGRASIYIGSSEDDGVLAIHVNAKL 494
            ||||||||||||||.|...:|||..|.|||||:|...|.:|.:|..:|||.::||
  Rat   454 TGLPAGTYCDVISGDKVNGNCTGLKVNVGSDGKAHFSISNSAEDPFIAIHADSKL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amy-d	NP_523768.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	216/390 (55%)
		Alpha-amylase	54..342	CDD:278554	170/297 (57%)
		Aamy_C	405..493	CDD:214749	54/87 (62%)
Amy2a3	NP_113690.2	AmyAc_bac_euk_AmyA	25..413	CDD:200456	216/390 (55%)
Amy2a3	NP_113690.2	Aamy_C	419..507	CDD:214749	54/87 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	273	1.000	Domainoid score	I1716
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134663
Inparanoid	1	1.050	576	1.000	Inparanoid score	I1004
OMA	1	1.010	-	-		QHG53143
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm8995
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	LDO	PTHR43447
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980