DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amy-d and amy2b

DIOPT Version :9

Sequence 1:	NP_523768.1	Gene:	Amy-d / 36932	FlyBaseID:	FBgn0000078	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001007948.1	Gene:	amy2b / 493323	XenbaseID:	XB-GENE-5725537	Length:	512	Species:	Xenopus tropicalis

Alignment Length:	512	Identity:	267/512 - (52%)
Similarity:	348/512 - (67%)	Gaps:	23/512 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KSIVCLSLLAVANAQFDTNYASGRSGMVHLFEWKWDDIAAECENFLGPNGYAGVQVSPVNENAV- 68
            |.:..|.::.:.:.|:|.|...|::.:||||||||:|||.|||.:|||||:.|||:||.|||.|
Frog     2 KLLFFLVVIKLCSGQYDPNVKPGKTSIVHLFEWKWEDIADECERYLGPNGFGGVQISPPNENLVI 66

  Fly    69 -KDSRPWWERYQPISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHMAADG---GTYGTGG 129
             |..|||.|||||:||:|.|||||||||..||.|||..||..|||.|.|||...|   |...|.|
Frog    67 TKPWRPWDERYQPVSYQLCTRSGNEEQFIDMVTRCNNAGVHIYVDTVINHMTGYGAGIGNSSTCG 131

  Fly   130 STASPSSKSYPGVPYSSLDF-NPTC-----AISNYNDANEVRNCELVGLRDLNQGNSYVQDKVVE 188
            |..:..::.:|.||||.||| |..|     .|.||||..:||:|:|:||.||.....||::|:.|
Frog   132 SYFNSGARDFPAVPYSFLDFSNYKCKSHSGGIENYNDPYQVRDCQLLGLLDLALEKDYVREKIAE 196

  Fly   189 FLDHLIDLGVAGFRVDAAKHMWPADLAVIYGRLKNLNTDHGFASGSKAYIVQEVIDMGGEAISKS 253
            ::::||::||||||:||:|||||.|:..|..||::|||. .|::|::.::.|||||:||||||.|
Frog   197 YMNNLINIGVAGFRLDASKHMWPGDIKAILNRLEDLNTT-WFSNGTRPFVYQEVIDLGGEAISAS 260

  Fly   254 EYTGLGAITEFRHSDSIGKVFR--GKDQLQYLTNWGTAWGFAASDRSLVFVDNHDNQRGHGAGGA 316
            :|.|.|.:|||::...:|.|.|  ..:::.||.|||..|||..|||:|||||||||||||||||:
Frog   261 DYFGTGRVTEFKYGAKLGTVIRRWNGEKMAYLRNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGS 325

  Fly   317 DVLTYKVPKQYKMASAFMLAHPFGTPRVMSSF----SFTDTD-----QGPPTTDGHNIASPIFNS 372
            .:||:...:.||||..||.|||:|..|||||:    .|.|..     .|||:....:.......:
Frog   326 SILTFFESQLYKMAVGFMHAHPYGFTRVMSSYRWPRHFADGKDINNWMGPPSNPDGSTQPVTIKA 390

  Fly   373 DNSCSGGWVCEHRWRQIYNMVAFRNAVGLDEIQNWWDSGSNQISFSRGSRGFVAFNNDNYDLNSS 437
            |.:|...||||||||||.|||.|||.|....:.||||:|:|||:|.||::||:.||||::||:.:
Frog   391 DTTCGNNWVCEHRWRQIKNMVIFRNVVDGQALTNWWDNGNNQIAFGRGNKGFIVFNNDDWDLDVT 455

  Fly   438 LQTGLPAGTYCDVISGSKSGSSCTGKTVTVGSDGRASIYIGSSEDDGVLAIHVNAKL 494
            |.||||||||||||||.|..:.|:||.:||..|..|...|.::.:|..:||||||||
Frog   456 LNTGLPAGTYCDVISGQKQDTMCSGKKITVNKDSTAHFQISNTAEDPFVAIHVNAKL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amy-d	NP_523768.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	208/392 (53%)
		Alpha-amylase	54..342	CDD:278554	162/300 (54%)
		Aamy_C	405..493	CDD:214749	49/87 (56%)
amy2b	NP_001007948.1	AmyAc_bac_euk_AmyA	25..417	CDD:200456	208/392 (53%)
amy2b	NP_001007948.1	Aamy_C	423..511	CDD:214749	49/87 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	264	1.000	Domainoid score	I1877
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	567	1.000	Inparanoid score	I1058
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm9418
Panther	1	1.100	-	-	O	PTHR43447
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4468
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190