DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amy-d and amy2a

DIOPT Version :9

Sequence 1:	NP_523768.1	Gene:	Amy-d / 36932	FlyBaseID:	FBgn0000078	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_998176.2	Gene:	amy2a / 406539	ZFINID:	ZDB-GENE-040426-2393	Length:	512	Species:	Danio rerio

Alignment Length:	513	Identity:	284/513 - (55%)
Similarity:	355/513 - (69%)	Gaps:	25/513 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KSIVCLSLLAVANAQFDTNYASGRSGMVHLFEWKWDDIAAECENFLGPNGYAGVQVSPVNENAVK 69
            |.::..:|:.::.||||.|..|||:.:||||||:|.|||||||.:|||||:.|||:||.:|:.|.
Zfish     2 KLLILAALVGLSLAQFDPNTKSGRTAIVHLFEWRWADIAAECERYLGPNGFGGVQISPPSESIVV 66

  Fly    70 DS--RPWWERYQPISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHMAADG---GTYGTGG 129
            .:  .|||:|||||.|.|.:|||||.:...|:.|||.|||..|||.|.|||...|   ||:.:.|
Zfish    67 TNPWHPWWQRYQPIGYNLCSRSGNENELKDMITRCNNVGVNIYVDAVINHMCGSGGGSGTHSSCG 131

  Fly   130 STASPSSKSYPGVPYSSLDFNP-TC-----AISNYNDANEVRNCELVGLRDLNQGNSYVQDKVVE 188
            |..:.::|.:|.||||:||||. .|     .|.||.|.|:||||.||||.||.....||:.||.:
Zfish   132 SYFNANNKDFPTVPYSNLDFNDGKCNTGSGNIENYQDINQVRNCRLVGLLDLALEKDYVRSKVAD 196

  Fly   189 FLDHLIDLGVAGFRVDAAKHMWPADLAVIYGRLKNLNTDHGFASGSKAYIVQEVIDMGGEAISKS 253
            :::.|||:|||||||||.|||||.||:.:||||.|||| ..|.||:|.:|.|||||:|||.|:.|
Zfish   197 YMNKLIDMGVAGFRVDACKHMWPGDLSAVYGRLHNLNT-RWFPSGAKPFIFQEVIDLGGEPITSS 260

  Fly   254 EYTGLGAITEFRHSDSIGKVFR--GKDQLQYLTNWGTAWGFAASDRSLVFVDNHDNQRGHGAGGA 316
            ||||:|.:|||::...:|.:.|  ..::|.||.|||..|||..||::||||||||||||||||||
Zfish   261 EYTGIGRVTEFKYGAKLGNIIRKWNGEKLSYLKNWGEGWGFMPSDKALVFVDNHDNQRGHGAGGA 325

  Fly   317 DVLTYKVPKQYKMASAFMLAHPFGTPRVMSSFSF-----TDTDQ----GPPTT-DGHNIASPIFN 371
            .::|:...:.||||..||||||:|..|||||:.:     ...||    |||:. ||.....|| |
Zfish   326 SIVTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWDRNIVNGQDQNDWIGPPSNGDGSTKPVPI-N 389

  Fly   372 SDNSCSGGWVCEHRWRQIYNMVAFRNAVGLDEIQNWWDSGSNQISFSRGSRGFVAFNNDNYDLNS 436
            .|::|...||||||||||.|||.|||.|......||||:|||||:||||||||:..|||:::||.
Zfish   390 PDSTCGDNWVCEHRWRQIKNMVIFRNVVNGQPFSNWWDNGSNQIAFSRGSRGFIIINNDDWELNV 454

  Fly   437 SLQTGLPAGTYCDVISGSKSGSSCTGKTVTVGSDGRASIYIGSSEDDGVLAIHVNAKL 494
            ||.||||.|||||||||.|....||||.|.||.||:||..|.:.|:|..:|||.::||
Zfish   455 SLSTGLPGGTYCDVISGQKENGRCTGKEVNVGGDGKASFRISNQEEDPFIAIHADSKL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amy-d	NP_523768.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	217/393 (55%)
		Alpha-amylase	54..342	CDD:278554	165/300 (55%)
		Aamy_C	405..493	CDD:214749	55/87 (63%)
amy2a	NP_998176.2	AmyAc_bac_euk_AmyA	25..417	CDD:200456	217/393 (55%)
amy2a	NP_998176.2	Aamy_C	424..511	CDD:214749	55/86 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576474
Domainoid	1	1.000	269	1.000	Domainoid score	I1797
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134663
Inparanoid	1	1.050	577	1.000	Inparanoid score	I1002
OMA	1	1.010	-	-		QHG53143
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm6522
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	LDO	PTHR43447
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4468
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800