DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amy-d and amy2al1

DIOPT Version :9

Sequence 1:	NP_523768.1	Gene:	Amy-d / 36932	FlyBaseID:	FBgn0000078	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_956722.1	Gene:	amy2al1 / 393400	ZFINID:	ZDB-GENE-040426-1606	Length:	512	Species:	Danio rerio

Alignment Length:	513	Identity:	273/513 - (53%)
Similarity:	354/513 - (69%)	Gaps:	25/513 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KSIVCLSLLAVANAQFDTNYASGRSGMVHLFEWKWDDIAAECENFLGPNGYAGVQVSPVNENAV- 68
            |.:|..:|:.:..:|.:||:...|:.:||||||:|.|||.|||.:|.||||.|||:||.:|:.|
Zfish     2 KLLVVAALVGLCLSQHNTNFKHNRTSIVHLFEWRWADIAKECERYLAPNGYGGVQISPPSESIVL 66

  Fly    69 -KDSRPWWERYQPISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHM--AADG-GTYGTGG 129
             |...|||:|||||||.|.:|||.||:...|:.|||.|||..|.|.|.|||  |:.| ||:.:.|
Zfish    67 TKPWHPWWQRYQPISYNLCSRSGTEEELKDMIARCNNVGVNIYADAVINHMCGASGGEGTHSSCG 131

  Fly   130 STASPSSKSYPGVPYSSLDFNPT-CA-----ISNYNDANEVRNCELVGLRDLNQGNSYVQDKVVE 188
            :..:..::.:|.|||||.|||.. |.     |.||:|..:||:|.||.|.||.....||:.||.|
Zfish   132 TYFNAKNEDFPSVPYSSWDFNDNKCKTANEDIENYSDIFQVRDCRLVSLLDLALEKDYVRGKVAE 196

  Fly   189 FLDHLIDLGVAGFRVDAAKHMWPADLAVIYGRLKNLNTDHGFASGSKAYIVQEVIDMGGEAISKS 253
            :::.|||:|||||||||.|||||.||:.:|.|||.|| :..|:.|:|.:|.|||||:|||.|..|
Zfish   197 YMNKLIDIGVAGFRVDACKHMWPGDLSNVYSRLKTLN-NTWFSPGTKPFIYQEVIDLGGEPIKAS 260

  Fly   254 EYTGLGAITEFRHSDSIGKVFR--GKDQLQYLTNWGTAWGFAASDRSLVFVDNHDNQRGHGAGGA 316
            ||..||.:|||::|..:|.|.|  .|::|.||.|||..|||..||::||||||||||||||||||
Zfish   261 EYVSLGRVTEFKYSAKLGTVIRKWEKEKLCYLKNWGEGWGFMPSDKALVFVDNHDNQRGHGAGGA 325

  Fly   317 DVLTYKVPKQYKMASAFMLAHPFGTPRVMSSFSF-----TDTDQ----GPPT-TDGHNIASPIFN 371
            .|||:...:.||:|:..|||||:|...||||:.:     ...||    |||: .||...:.|| |
Zfish   326 SVLTFWDSRLYKIATGLMLAHPYGVTAVMSSYRWDRHFVNGKDQNDWMGPPSNADGSTKSVPI-N 389

  Fly   372 SDNSCSGGWVCEHRWRQIYNMVAFRNAVGLDEIQNWWDSGSNQISFSRGSRGFVAFNNDNYDLNS 436
            .|::|...|:||||||||.|||.|||.|....:.||||:.:|||:|||||:||:..||:::|||.
Zfish   390 PDSTCGDNWICEHRWRQIRNMVNFRNVVNGQPLSNWWDNNNNQIAFSRGSKGFIVINNNDWDLNV 454

  Fly   437 SLQTGLPAGTYCDVISGSKSGSSCTGKTVTVGSDGRASIYIGSSEDDGVLAIHVNAKL 494
            .|:||||:|||||:|||.|||:|||||.|||.|||:|:..|..:|:|..:|||.::||
Zfish   455 MLKTGLPSGTYCDIISGDKSGNSCTGKQVTVDSDGQATFSICHTEEDPFMAIHADSKL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amy-d	NP_523768.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	211/393 (54%)
		Alpha-amylase	54..342	CDD:278554	163/300 (54%)
		Aamy_C	405..493	CDD:214749	53/87 (61%)
amy2al1	NP_956722.1	AmyAc_bac_euk_AmyA	25..417	CDD:200456	211/393 (54%)
		AmyA	46..>315	CDD:223443	142/269 (53%)
		Aamy_C	424..511	CDD:214749	53/86 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576490
Domainoid	1	1.000	269	1.000	Domainoid score	I1797
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	577	1.000	Inparanoid score	I1002
OMA	1	1.010	-	-		QHG53143
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm6522
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	O	PTHR43447
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770