DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amy-d and AMY2B

DIOPT Version :9

Sequence 1:	NP_523768.1	Gene:	Amy-d / 36932	FlyBaseID:	FBgn0000078	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001373038.1	Gene:	AMY2B / 280	HGNCID:	478	Length:	511	Species:	Homo sapiens

Alignment Length:	512	Identity:	273/512 - (53%)
Similarity:	339/512 - (66%)	Gaps:	24/512 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KSIVCLSLLAVANAQFDTNYASGRSGMVHLFEWKWDDIAAECENFLGPNGYAGVQVSPVNENAV- 68
            |..:.|..:....||:..|...||:.:||||||:|.|||.|||.:|.|.|:.||||||.|||..
Human     2 KFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNENVAI 66

  Fly    69 -KDSRPWWERYQPISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHM---AADGGTYGTGG 129
             ...|||||||||:||||.||||||::|.:||.|||.||||.|||.|.|||   |...||..|.|
Human    67 HNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMSGNAVSAGTSSTCG 131

  Fly   130 STASPSSKSYPGVPYSSLDFNP-TCA-----ISNYNDANEVRNCELVGLRDLNQGNSYVQDKVVE 188
            |..:|.|:.:|.||||..|||. .|.     |.|||||.:||:|.||||.||.....||:.|:.|
Human   132 SYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLVGLLDLALEKDYVRSKIAE 196

  Fly   189 FLDHLIDLGVAGFRVDAAKHMWPADLAVIYGRLKNLNTDHGFASGSKAYIVQEVIDMGGEAISKS 253
            :::||||:||||||:||:|||||.|:..|..:|.|||: :.|.:|||.:|.|||||:|||.|..|
Human   197 YMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNS-NWFPAGSKPFIYQEVIDLGGEPIKSS 260

  Fly   254 EYTGLGAITEFRHSDSIGKVFR--GKDQLQYLTNWGTAWGFAASDRSLVFVDNHDNQRGHGAGGA 316
            :|.|.|.:|||::...:|.|.|  ..:::.||.|||..|||..|||:||||||||||||||||||
Human   261 DYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGA 325

  Fly   317 DVLTYKVPKQYKMASAFMLAHPFGTPRVMSSFSFTDTDQ---------GPPTTDGHNIASPIFNS 372
            .:||:...:.||||..||||||:|..|||||:.:....|         |||..:| .|.....|.
Human   326 SILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRQFQNGNDVNDWVGPPNNNG-VIKEVTINP 389

  Fly   373 DNSCSGGWVCEHRWRQIYNMVAFRNAVGLDEIQNWWDSGSNQISFSRGSRGFVAFNNDNYDLNSS 437
            |.:|...||||||||||.|||.|||.|......||:|:||||::|.||:|||:.||||::..:.:
Human   390 DTTCGNDWVCEHRWRQIRNMVNFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWTFSLT 454

  Fly   438 LQTGLPAGTYCDVISGSKSGSSCTGKTVTVGSDGRASIYIGSSEDDGVLAIHVNAKL 494
            ||||||||||||||||.|...:|||..:.|..||:|...|.:|.:|..:|||..:||
Human   455 LQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESKL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amy-d	NP_523768.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	217/392 (55%)
		Alpha-amylase	54..342	CDD:278554	171/300 (57%)
		Aamy_C	405..493	CDD:214749	47/87 (54%)
AMY2B	NP_001373038.1	AmyAc_bac_euk_AmyA	25..416	CDD:200456	217/392 (55%)
		PLN02447	<85..>155	CDD:215246	39/69 (57%)
		Aamy_C	422..510	CDD:214749	47/87 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1866
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134663
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1140
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53143
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm8522
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	LDO	PTHR43447
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4468
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870