Protein Alignment Amy-d and AMY1C

DIOPT Version :10

• Sequence 1: NP_523768.1
• Gene: Amy-d / 36932
• FlyBaseID: FBgn0000078
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001008220.1
• Gene: AMY1C / 278
• HGNCID: 476
• Length: 511
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 270/500 - (54%)
• Similarity: 337/500 - (67%)
• Gaps: 26/500 - (5%)

  Fly    18 AQFDTNYASGRSGMVHLFEWKWDDIAAECENFLGPNGYAGVQVSPVNENAV--KDSRPWWERYQP 80
            ||:.:|...||:.:||||||:|.|||.|||.:|.|.|:.||||||.|||..  ...|||||||||
Human    15 AQYSSNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNENVAIHNPFRPWWERYQP 79

  Fly    81 ISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHM---AADGGTYGTGGSTASPSSKSYPGV 142
            :||||.||||||::|.:||.|||.||||.|||.|.|||   |...||..|.||..:|.|:.:|.|
Human    80 VSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGNAVSAGTSSTCGSYFNPGSRDFPAV 144

  Fly   143 PYSSLDFNP-TCA-----ISNYNDANEVRNCELVGLRDLNQGNSYVQDKVVEFLDHLIDLGVAGF 201
            |||..|||. .|.     |.|||||.:||:|.|.||.||..|..||:.|:.|:::||||:|||||
Human   145 PYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLSGLLDLALGKDYVRSKIAEYMNHLIDIGVAGF 209

  Fly   202 RVDAAKHMWPADLAVIYGRLKNLNTDHGFASGSKAYIVQEVIDMGGEAISKSEYTGLGAITEFRH 266
            |:||:|||||.|:..|..:|.|||: :.|..|||.:|.|||||:|||.|..|:|.|.|.:|||::
Human   210 RIDASKHMWPGDIKAILDKLHNLNS-NWFPEGSKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKY 273

  Fly   267 SDSIGKVFR--GKDQLQYLTNWGTAWGFAASDRSLVFVDNHDNQRGHGAGGADVLTYKVPKQYKM 329
            ...:|.|.|  ..:::.||.|||..|||..|||:||||||||||||||||||.:||:...:.|||
Human   274 GAKLGTVIRKWNGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKM 338

  Fly   330 ASAFMLAHPFGTPRVMSSFSF-------TDTDQ--GPPTTDGHNIASPI-FNSDNSCSGGWVCEH 384
            |..||||||:|..|||||:.:       .|.:.  |||..:|  :...: .|.|.:|...|||||
Human   339 AVGFMLAHPYGFTRVMSSYRWPRYFENGKDVNDWVGPPNDNG--VTKEVTINPDTTCGNDWVCEH 401

  Fly   385 RWRQIYNMVAFRNAVGLDEIQNWWDSGSNQISFSRGSRGFVAFNNDNYDLNSSLQTGLPAGTYCD 449
            |||||.|||.|||.|......||:|:||||::|.||:|||:.||||::..:.:||||||||||||
Human   402 RWRQIRNMVNFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWTFSLTLQTGLPAGTYCD 466

  Fly   450 VISGSKSGSSCTGKTVTVGSDGRASIYIGSSEDDGVLAIHVNAKL 494
            ||||.|...:|||..:.|..||:|...|.:|.:|..:|||..:||
Human   467 VISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESKL 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Amy-d	NP_523768.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	216/393 (55%)
		Aamy_C	405..493	CDD:214749	47/87 (54%)
AMY1C	NP_001008220.1	AmyAc_bac_euk_AmyA	25..416	CDD:200456	216/393 (55%)
		Aamy_C	422..510	CDD:214749	47/87 (54%)